Estrogen replacement therapy decreases plasma adiponectin but not resistin in postmenopausal women

Kunnari, Anne; Santaniemi, Merja; Jokela, Maarit; Karjalainen, Anna; Heikkinen, Jorma; Ukkola, Olavi; Kesäniemi, Y. Antero

doi:10.1016/j.metabol.2008.06.004

Cited by 31 publications

(29 citation statements)

References 40 publications

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“…Some investigators have shown that transition to menopause is accompanied with increased circulating APN [25], which is consistent with the data on estrogen-dependent suppression of APN [24]. Others, however, have reported lack of correlations between age and APN in females [22,26] or between serum APN and estradiol levels [27,28], very small [25] or no [27] differences in APN between pre- and post-menopausal women, and very small [28] or no [27] effects of estrogen replacement therapy on APN in post-menopausal females. With respect to T-cad, its expression was upregulated in castrated mice and downregulated following androgen replacement [29], while estradiol and progesterone were reported to upregulate T-cad expression in osteosarcoma cells in vitro [30].…”

Section: Discussionsupporting

confidence: 71%

Gender-Specific Associations between Circulating T-Cadherin and High Molecular Weight-Adiponectin in Patients with Stable Coronary Artery Disease

et al. 2015

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Close relationships exist between presence of adiponectin (APN) within vascular tissue and expression of T-cadherin (T-cad) on vascular cells. APN and T-cad are also present in the circulation but here their relationships are unknown. This study investigates associations between circulating levels of high molecular weight APN (HMW-APN) and T-cad in a population comprising 66 women and 181 men with angiographically proven stable coronary artery disease (CAD). Plasma HMW-APN and T-cad were measured by ELISA and analysed for associations with baseline clinical characteristics and with each other. In multivariable analysis BMI and HDL were independently associated with HMW-APN in both genders, while diabetes and extent of coronary stenosis were independently associated with T-cad in males only. Regression analysis showed no significant association between HMW-APN and T-cad in the overall study population. However, there was a negative association between HMW-APN and T-cad (P=0.037) in a subgroup of young men (age <60 years, had no diabetes and no or 1-vessel CAD) which persisted after multivariable analysis with adjustment for all potentially influential variables (P=0.021). In the corresponding subgroup of women there was a positive association between HMW-APN and T-cad (P=0.013) which disappeared after adjustment for HDL. After exclusion of the young men, a positive association (P=0.008) between HMW-APN and T-cad was found for the remaining participants of the overall population which disappeared after adjustment for HDL and BMI. The existence of opposing correlations between circulating HMW-APN and T-cad in male and female patient populations underscores the necessity to consider gender as a confounding variable when evaluating biomarker potentials of APN and T-cad.

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Section: Discussionsupporting

confidence: 71%

Gender-Specific Associations between Circulating T-Cadherin and High Molecular Weight-Adiponectin in Patients with Stable Coronary Artery Disease

et al. 2015

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“…One study found that postmenopausal women taking estrogen replacement therapy showed lower adiponectin levels compared with women without estrogen supplementation. 32 Some animal models also indicated a negative correlation between high estrogen levels and low adiponectin secretion by adipocytes. 33 However, we did not find any clear correlation between the levels of estradiol and mRNA expression of adiponectin.…”

Section: Discussionmentioning

confidence: 99%

Olive Leaf Extract Elevates Hepatic PPARαmRNA Expression and Improves Serum Lipid Profiles in Ovariectomized Rats

Yoon

Liu

Park

et al. 2015

Journal of Medicinal Food

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We hypothesized that olive leaf extract might alleviate dyslipidemia resulting from estrogen deficiency. Serum lipid profile and mRNA expression of the related genes in the liver and adipose tissue were analyzed after providing olive leaf extract (200 or 400 mg/kg body weight; n = 7 for each group) to ovariectomized rats for 10 weeks. After 10 weeks' administration, the rats in the olive leaf extract-administered groups showed significantly lower levels of serum triglyceride and verylow-density lipoprotein (VLDL)-cholesterol compared with the rats in the control group, whereas the administration of olive leaf extract did not significantly change the elevated low-density lipoprotein cholesterol levels. In addition, administration of high dose of olive leaf extract significantly decreased the liver triglyceride and increased serum estradiol levels. mRNA expressions of peroxisome proliferator-activated receptor alpha (PPAR a) and acyl-CoA oxidase (ACO) were not affected by ovariectomy, however, administration of olive leaf extract significantly increased both PPAR a and ACO mRNA expression. Expression of adiponectin mRNA in adipose tissue was significantly decreased in the ovariectomized control group. Rats administered lowdose olive leaf extract showed significantly elevated adiponectin mRNA expression compared with rats in the ovariectomized control group. Even though dose-dependent effects were not observed in most of the measurements, these results suggest that genes involved in lipid metabolism may be regulated by olive leaf extract administration in ovariectomized rats.

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“…A number of endocrine factors, including androgens [1] and estrogens [22], [23], [24] are known to influence adiponectin concentrations. In particular, previous reports indicate that testosterone lowers total adiponectin within the circulation [6], [13], [17], [18], [34], which is surprising given the known lipolytic [11], [15], [16] and insulin sensitizing [35] effects of testosterone.…”

Section: Discussionmentioning

confidence: 99%

“…Similar to testosterone, E 2 [22], [23], [24] and estrogen mimicking agents [25], [26] have been reported to reduce circulating adiponectin concentrations. Additionally, a number of studies have reported a negative relationship between circulating E 2 and adiponectin [27], [28].…”

Section: Introductionmentioning

confidence: 99%

Influence of Androgens on Circulating Adiponectin in Male and Female Rodents

et al. 2012

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Several endocrine factors, including sex-steroid hormones are known to influence adiponectin secretion. Our purpose was to evaluate the influence of testosterone and of the synthetic non-aromatizable/non-5α reducible androgen 17β-hydroxyestra-4,9,11-trien-3-one (trenbolone) on circulating adiponectin and adiponectin protein expression within visceral fat. Young male and female F344 rats underwent sham surgery (SHAM), gonadectomy (GX), or GX plus supraphysiologic testosterone-enanthate (TE) administration. Total circulating adiponectin was 39% higher in intact SHAM females than SHAM males (p<0.05). GX increased total adiponectin by 29–34% in both sexes (p<0.05), while TE reduced adiponectin to concentrations that were 46–53% below respective SHAMs (p≤0.001) and ablated the difference in adiponectin between sexes. No differences in high molecular weight (HMW) adiponectin were observed between sexes or treatments. Adiponectin concentrations were highly and negatively associated with serum testosterone (males: r = −0.746 and females: r = −0.742, p≤0.001); however, no association was present between adiponectin and estradiol. In separate experiments, trenbolone-enanthate (TREN) prevented the GX-induced increase in serum adiponectin (p≤0.001) in young animals, with Low-dose TREN restoring adiponectin to the level of SHAMs and higher doses of TREN reducing adiponectin to below SHAM concentrations (p≤0.001). Similarly, TREN reduced adiponectin protein expression within visceral fat (p<0.05). In adult GX males, Low-dose TREN also reduced total adiponectin and visceral fat mass to a similar magnitude as TE, while increasing serum HMW adiponectin above SHAM and GX animals (p<0.05). Serum adiponectin was positively associated with visceral fat mass in young (r = 0.596, p≤0.001) and adult animals (r = 0.657, p≤0.001). Our results indicate that androgens reduce circulating total adiponectin concentrations in a dose-dependent manner, while maintaining HMW adiponectin. This change is directionally similar to the androgen-induced lipolytic effects on visceral adiposity and equal in magnitude between TE and TREN, suggesting that neither the aromatization nor the 5α reduction of androgens is required for this effect.

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Estrogen replacement therapy decreases plasma adiponectin but not resistin in postmenopausal women

Cited by 31 publications

References 40 publications

Gender-Specific Associations between Circulating T-Cadherin and High Molecular Weight-Adiponectin in Patients with Stable Coronary Artery Disease

Gender-Specific Associations between Circulating T-Cadherin and High Molecular Weight-Adiponectin in Patients with Stable Coronary Artery Disease

Olive Leaf Extract Elevates Hepatic PPARαmRNA Expression and Improves Serum Lipid Profiles in Ovariectomized Rats

Influence of Androgens on Circulating Adiponectin in Male and Female Rodents

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