Estrogen regulation of cell proliferation and distribution of estrogen receptor‐α in the brains of adult female prairie and meadow voles

Fowler, Christie D.; Johnson, Frank; Wang, Zuoxin

doi:10.1002/cne.20638

Cited by 90 publications

(81 citation statements)

References 113 publications

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“…Smith et al (2001) observed an increase in SVZ and OB proliferation in oestrus prairie voles exposed to a male behind a mesh fence. In line with the presence of estrogen receptors in the SVZ (Fowler et al, 2005), this socially-induced surge in proliferation was not observed in ovariectomized females, and was rescued by estradiol treatment. Interestingly, estradiol administration in isolation does not exert an effect on SVZ proliferation (Hnatczuk et al, 1994).…”

Section: Gonadal Control Of Adult Neurogenesismentioning

confidence: 59%

Social regulation of adult neurogenesis in a eusocial mammal

et al. 2014

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The present study examined social status and adult neurogenesis in the naked mole rat. These animals live in large colonies with a strict reproductive dominance hierarchy; one female and 1-3 males breed, while other members are subordinate and reproductively suppressed. We examined whether social status affects doublecortin (DCX; a marker for immature neurons) immunoreactivity in the dentate gyrus, piriform cortex (PCx), and basolateral amygdala (BLA) by comparing breeders to subordinates. We also examined subordinates removed from their colony and paired with opposite-or same-sex conspecifics for 6 months. Breeders had reduced DCX immunoreactivity in all areas, with BLA effects confined to females. Effects of housing condition were region-specific, with higher PCx DCX immunoreactivity observed in oppositethan same-sex paired subordinates regardless of gonadal status. The opposite pattern was observed in the BLA. Future work will clarify whether findings are attributable to status differences in stress, behavioural plasticity, or life stage.iii

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Section: Gonadal Control Of Adult Neurogenesismentioning

confidence: 59%

Social regulation of adult neurogenesis in a eusocial mammal

et al. 2014

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“…The amygdala, which is a potential site for estrogen modulation of feeding behavior (Geary, 2001), is sensitive to circulating steroids (e.g. Jasnow et al, 2006), shows steroiddependent neurogenesis (Fowler et al, 2005), and develops novel neuronal connections during adolescence (e.g. Cunningham et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

An association of early puberty with disordered eating and anxiety in a population of undergraduate women and men

Zehr

Culbert

Sisk

et al. 2007

Hormones and Behavior

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Eating and anxiety disorders are more prevalent in females, increase during adolescence, and are associated with early pubertal development. This study examined whether timing of puberty onset is associated with disordered eating and anxiety in a large sample of post-pubertal male and female undergraduate students. Self-report questionnaires assessed timing of puberty, disordered eating, anxiety, alcohol use, personality, and sensation seeking. Females scored significantly higher on measures of disordered eating (binge eating, dietary restraint, eating concerns, and weight and shape concerns) and anxiety (state and trait anxiety) than did males. In addition, early maturing women and men scored significantly higher on measures of disordered eating and anxiety than on-time or late maturing women and men. Measures of alcohol use, sensation seeking, and personality characteristics differed in males and females but did not vary with pubertal timing. Findings suggest that early puberty is associated with disordered eating and anxiety, and this association may be due to an organizational effect of pubertal hormones. Despite important differences in body fat composition, both males and females experiencing early puberty had an increased incidence of disordered eating. The fact that early puberty was associated with increased eating and anxiety symptoms in both sexes suggests that puberty may influence these symptoms through both biological and psychosocial mechanisms.

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“…Changes in gonadal hormones associated with these interactions also may contribute to these alterations in neurogenesis [8,9, reviewed in 11]. In addition to established proliferative zones (DG and SVZ) cell proliferation in the amygdala is responsive to alterations of social environment and hormonal treatments in prairie voles [8,9,10]. Based upon the existence of proliferation in this nucleus and its well established role in social behaviors, including parental behaviors, we performed measurements within select subdivisions (medial and central nuclei) of the amygdala in addition to the DG and SVZ.…”

Section: Adult Neurogenesis Occurs In Several Mammalian Species [Revimentioning

confidence: 99%

Pup exposure elicits hippocampal cell proliferation in the prairie vole

Ruscio

Sweeny

Hazelton

et al. 2008

Behavioural Brain Research

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The onset of parental behavior has profound and enduring effects on behavior and neurobiology across a variety of species. In some cases, mere exposure to a foster neonate (and a subsequent parental response) can have similar effects. In the present experiment we exposed adult male and female prairie voles (Microtus ochrogaster) to two foster pups for twenty minutes and quantified cell proliferation in the dentate gyrus of the hippocampus (DG), medial amygdala (MeA) and cortical amygdala (CorA). Prairie voles are highly social rodents that typically display biparental care and spontaneous parental care when exposed to foster pups. Comparisons were made between the animals that responded parentally or non-parentally towards the pups, as well as control conditions. Cell proliferation was assessed using injections of 5-bromo-2'-deoxyuridine (BrdU) and immunocytochemical localization of this marker. The phenotype of the cells was determined using double label immufluoresence for BrdU and TuJ1 (a neuronal marker). An increase in cell proliferation in the DG was seen in animals exposed to pups. However, animals that responded nonparentally had a greater number of BrdU labeled cells in the DG compared to those that responded parentally. The majority of BrdU labeled cells co-expressed TuJ1 across all groups. These results demonstrate that exposure to a foster pup, and the behavioral reaction to it (parental or non-parental) is associated with site-specific changes in cell proliferation.

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Estrogen regulation of cell proliferation and distribution of estrogen receptor‐α in the brains of adult female prairie and meadow voles

Cited by 90 publications

References 113 publications

Social regulation of adult neurogenesis in a eusocial mammal

Social regulation of adult neurogenesis in a eusocial mammal

An association of early puberty with disordered eating and anxiety in a population of undergraduate women and men

Pup exposure elicits hippocampal cell proliferation in the prairie vole

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