Estrogen regulation of agonistic and proceptive responses in the golden hamster

Lisk, Robert D.; Nachtigall, Margaret J.

doi:10.1016/0018-506x(88)90029-3

Cited by 32 publications

(14 citation statements)

References 25 publications

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“…This is because few studies have used the same methods to directly compare the behavior of males and females. Payne & Swanson (1970) showed that in same-sex encounters males and females did not differ in levels of agonistic behavior but there was a high degree of variability in female agonistic behavior over the estrous cycle (see also Lisk and Nachtigall, 1988;Takahashi and Lisk, 1983;Takahashi and Lisk, 1984). Since the studies by Payne & Swanson (1970), other researchers have described females as being more aggressive than males.…”

Section: Introductionmentioning

confidence: 99%

Dominant–subordinate relationships in hamsters: Sex differences in reactions to familiar opponents

Bath

Johnston

2007

Hormones and Behavior

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In the majority of mammalian species, males are dominant over and more aggressive than females. In contrast, some reports suggest that female golden hamsters are more aggressive than males but systematic comparisons using the same methods for both sexes are rare. We observed same-sexed pairs of hamsters over repeated trials to assess whether sex differences existed in the level of agonistic behavior and in the development and maintenance of dominant-subordinate relationships with familiar partners. There were no sex differences in measures of agonistic behavior or fear responses (fleeing) during the initial series of three trials on the first day of testing. Following a four-day interval, males that had lost in session 1 showed fearful responses to a familiar dominant male and were not likely to engage in a fight with him. In contrast, females that lost the initial fights were not fearful and fought vigorously with the familiar winner in subsequent encounters. Although the amount of agonistic behavior engaged in by females did decrease over the course of the three sessions, females that lost did not demonstrate an increase in fear, as measured by the latency to flee. Males that lost fights did show increased fear during later trials and sessions. These results suggest that female hamsters are less affected by losing fights than males are and thus that females are less likely than males to develop highly polarized dominant-subordinate relationships. Further work is needed to understand the mechanisms underlying these sex differences.

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Section: Introductionmentioning

confidence: 99%

Dominant–subordinate relationships in hamsters: Sex differences in reactions to familiar opponents

Bath

Johnston

2007

Hormones and Behavior

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“…Ovariectomized female hamsters display high levels of aggression [Ciaccio et al, 1979;Floody and Pfaff, 1977;Fraile et al, 1987;Meisel et al, 1988;Takahashi and Lisk, 1983;Vandenbergh, 1971]. When ovariectomized females are treated with estradiol there are typically no effects on aggression [Fraile et al, 1987;Meisel et al, 1988;Payne and Swanson, 1972;Sterner et al, 1992;Vandenbergh, 1971], though some studies report an inhibition of aggression [Carter et al, 1973;Ciaccio et al, 1979;Lisk and Nachtigall, 1988]. The combination of estradiol and progesterone treatment, which mimics the sequence of steroid release from the ovaries of intact females, invariably eliminates aggression [Ciaccio et al, 1979;Floody and Pfaff, 1977;Meisel et al, 1988;Takahashi and Lisk, 1983;Tiefer, 1970;Wise, 1974].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of aggression by progesterone and its metabolites in female Syrian hamsters

Kohlert

Meisel

2001

Aggressive Behavior

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The sequence of estradiol and progesterone is known to inhibit the expression of aggression in female hamsters. Despite the key importance of progesterone in the inhibition of aggression, little is known of the mechanisms through which progesterone may exert this effect. Three experiments were performed to assess the degree to which metabolites of progesterone can affect aggression in female Syrian hamsters. Systemic estradiol treatment followed by injections of either progesterone (300 mg IP) or 4-pregnen-21-ol-3,20-dione (DOC, 300 mg IP) reliably inhibited aggression. Systemic injection (75, 150, or 300 mg IP) of either 5a-pregnan-3a,21-diol-20-one (THDOC) or 5a-pregnan-3a-ol-20-one (3a,5a-THP) did not affect aggression. Intracerebroventricular infusion of 3a,5a-THP following systemic estradiol treatment also did not affect aggression. In a third experiment, female hamsters were given systemic treatments with estradiol and progesterone that were subthreshold with respect to inhibition of aggression. In these females, intracerebroventricular infusion of THDOC inhibited aggression. These results indicate that metabolites of progesterone can inhibit aggression, most notably in synergy with progesterone itself. Aggr. Behav. 27:372-381, 2001.

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“…The present data suggest that the aggressive behavior displayed by the resident female vis-à-vis with an ovariectomized intruder in this paradigm is clearly cycle-dependent, with almost no aggressive behavior displayed during the receptive phases (proestrus and estrus) of the cycle, and marked aggressive behavior displayed during the non-receptive phases (metestrus and diestrus phases). Likewise, using other models of aggression, Calhoun (1962), Swanson and coworkers (Swanson et al 1982), andHood (1984) have reported that aggressive behavior in female rats may be cycle-dependent; in addition, estrus cycle-related variations in aggressive behavior have been demonstrated in mice (Hyde and Sawyer 1977), hamsters (Floody and Pfaff 1977), cows (Castellanos et al 1992), and nonhuman primates (Hausfater and Skoblick 1985;Lisk and Nachtigall 1988;Rapkin et al 1995).Women with PMDD usually display marked irritability, anger, and affect lability during one to two weeks preceding the onset of menstruation, but no such symptoms from day 3-5 of the cycle and until ovulation. Several studies suggest that premenstrual complaints are triggered by the high mid-cycle levels of progesterone and/or estradiol, and appearing with a delay of approximately one week (or less) .…”

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confidence: 99%

The Serotonin Reuptake Inhibitor Fluoxetine Reduces Sex Steroid-Related Aggression in Female Rats An Animal Model of Premenstrual Irritability?

2001

Neuropsychopharmacology

106

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The aggressive behavior displayed by some (but not all) female Wistar rats when an unfamiliar rat is being introduced into their home cage (the resident intruder paradigm) was found to be higher in non-receptive phases (metestrus, diestrus) than in the receptive phases (proestrus, estrus) Premenstrual dysphoric disorder (PMDD) is characterized by a constellation of symptoms appearing regularly in the luteal phase of the cycle, and disappearing within a few days after the onset of menstruation (American Psychiatric Association 1994). Most researchers in the field regard irritability and anger as the cardinal symptoms of PMDD, but sadness, affect lability, and tension also are common complaints (see Steiner 1997;Freeman and Halbreich 1998;Eriksson 1999).The hypothesis that ovarian steroids are of importance for the pathophysiology of PMDD gains support not only from the fact that the onset and disappearance of symptoms are linked to the reproductive cycle, but also from the findings that premenstrual complaints may be reduced by surgical ovariectomy and by druginduced inhibition of ovulation (see Backstrom and Hammarback 1991;Schmidt et al. 1998). Several observations suggest that PMDD subjects do not differ from controls with respect to serum levels of sex steroids, but with respect to how the brain reacts to these hormones. First, most studies suggest that replacing endogenous sex steroid secretion with exogenous hormones in the form of oral contraceptives is usually not an effective treatment for PMDD (Bancroft and Rennie 1993). Second, treatment with progesterone and/or estrogen after administration of an ovulation inhibitor has been shown to elicit PMDD-like symptoms in women with a history From the Department of Pharmacology, Göteborg University, Göteborg, Sweden.Address correspondence to: Hoi-Por Ho, Department of Pharmacology, Göteborg University, POB 431, SE 405 30 Göteborg, Sweden.Received April 25, 2000; revised October 6, 2000; accepted October 18, 2000. N EUROPSYCHOPHARMACOLOGY 2001 -VOL . 24 , NO . 5 Animal Model of Premenstrual Dysphoria? 503 of PMDD, but not in controls . Third, women with a history of PMDD more often than other women experience PMDD-like symptoms when given gestagen intermittently during menopause as part of a hormonal replacement therapy (Bjorn et al. 1999). Animal experiments suggest that the brain neurotransmitter serotonin exerts an inhibitory influence on irritability and aggression (see Eriksson and Humble 1990), and also that brain serotonergic neurotransmission is influenced by sex steroids . The hypothesis that serotonin may be involved in the regulation of premenstrual irritability lends strong support from studies showing that serotonin reuptake inhibitors very effectively reduce the symptoms of PMDD (Sundblad et al. 1992;Eriksson et al. 1995;Steiner et al. 1995;Yonkers et al. 1997;Wikander et al. 1998); moreover, whereas the serotonin precursor tryptophan has been shown to be superior to placebo for the treatment of PMDD (Steinberg et al. 1999), a reduction i...

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Estrogen regulation of agonistic and proceptive responses in the golden hamster

Cited by 32 publications

References 25 publications

Dominant–subordinate relationships in hamsters: Sex differences in reactions to familiar opponents

Dominant–subordinate relationships in hamsters: Sex differences in reactions to familiar opponents

Inhibition of aggression by progesterone and its metabolites in female Syrian hamsters

The Serotonin Reuptake Inhibitor Fluoxetine Reduces Sex Steroid-Related Aggression in Female Rats An Animal Model of Premenstrual Irritability?

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