Estrogen regulates the expression of Ndrg2 in astrocytes

Ma, Yulong; Qin, Pei; Feng, Dayun; Li, Yan; Zhang, Lixia; Liu, Zhaoyu; Yin, Anqi; Wen-hong, Tang; Dong, Hailong; Meng, Lingzhong; Hou, Wugang; Xiong, Lize

doi:10.1016/j.brainres.2014.04.036

Cited by 23 publications

(21 citation statements)

References 40 publications

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“…However, there is still an important gap in our knowledge on the signaling mechanism involved in the action of gonadal hormones on astrocytes. The use of selective agonists and selective antagonists for ERs and the selective removal of ERs on astrocytes have contributed to identify the ER subtypes involved in the actions of estradiol and estrogenic compounds on astrocytes (Guo et al, 2012;Kuo et al, 2010b;Lewis et al, 2008;Ma et al, 2014;Spence et al, 2013Spence et al, , 2011.…”

Section: Conclusion and Perspectives For The Futurementioning

confidence: 99%

Regulation of astroglia by gonadal steroid hormones under physiological and pathological conditions

Acaz‐Fonseca

Ávila-Rodriguez

Garcia-Segura

et al. 2016

Progress in Neurobiology

104

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Section: Conclusion and Perspectives For The Futurementioning

confidence: 99%

Regulation of astroglia by gonadal steroid hormones under physiological and pathological conditions

Acaz‐Fonseca

Ávila-Rodriguez

Garcia-Segura

et al. 2016

Progress in Neurobiology

104

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“…Similarly, following kainic acid induced injury, astrocyte proliferation is enhanced in aging females as compared to aging males (Zhang et al, 2008). There is evidence that estrogen may influence astrocyte proliferation by increasing N-myc downstream-regulated gene 2 expression, a protein known to inhibit cell proliferation (Ma et al, 2014). …”

Section: Reactive Astrocytes: Influence Of Ovarian Hormonesmentioning

confidence: 99%

Astrocytic response to cerebral ischemia is influenced by sex differences and impaired by aging

Chisholm

Sohrabji

2016

Neurobiology of Disease

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Ischemic stroke occurs more often among the elderly, and within this demographic, women are at an increased risk for stroke and have poorer functional recovery than men. This is also well replicated in animal studies where aging females are shown to have more extensive brain tissue loss as compared to adult females. Astrocytes provide nutrients for neurons, regulate glutamate levels, and release neurotrophins and thus play a key role in the events that occur following ischemia. In addition, astrocytes express receptors for gonadal hormones and synthesize several neurosteroids suggesting that the sex differences in stroke outcome may be mediated through astrocytes. This review discusses key astrocytic responses to ischemia including, reactive gliosis, excitotoxicity, and neuroinflammation. In light of the age and sex differences in stroke outcomes, this review highlights how aging and gonadal hormones influence these responses. Lastly, astrocyte specific changes in gene expression and epigenetic modifications during aging and following ischemia are discussed as possible molecular mechanisms for impaired astrocytic functioning.

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“…The synergistic actions of E 2 and P 4 are critical for regulation of the estrous cycle and establishment of uterine receptivity [ 27 , 28 ]. A putative estrogen-response element (ERE) is located in the promoter region of the NDRG2 gene, and NDRG2 expression in astrocytes is regulated by estrogen [ 29 , 30 ]. In the present study, we found that both E 2 and P 4 had stimulatory effects on uterine NDRG2 expression in ovariectomized mice (Fig.…”

Section: Discussionmentioning

confidence: 99%

Uterine NDRG2 expression is increased at implantation sites during early pregnancy in mice, and its down-regulation inhibits decidualization of mouse endometrial stromal cells

Zhang

Yang

et al. 2015

Reprod Biol Endocrinol

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BackgroundN-myc down-regulated gene 2 (NDRG2) is a tumor suppressor involved in cell proliferation and differentiation. The aim of this study was to determine the uterine expression pattern of this gene during early pregnancy in mice.MethodsUterine NDRG2 mRNA and protein expression levels were determined by RT-PCR and Western blot analyses, respectively, during the peri-implantation period in mice. Immunohistochemical (IHC) analysis was performed to examine the spatial localization of NDRG2 expression in mouse uterine tissues. The in vitro decidualization model of mouse endometrial stromal cells (ESCs) was used to evaluate decidualization of ESCs following NDRG2 knock down by small interfering RNA (siRNA). Statistical significance was analyzed by one-way ANOVA using SPSS 19.0 software.ResultsUterine NDRG2 gene expression was significantly up-regulated and was predominantly localized to the secondary decidual zone on days 5 and 8 of pregnancy in mice. Its increased expression was associated with artificial decidualization as well as the activation of delayed implantation. Furthermore, uterine NDRG2 expression was induced by estrogen and progesterone treatments. The in vitro decidualization of mouse ESCs was accompanied by up-regulation of NDRG2 expression, and knock down of its expression in these cells by siRNA inhibited the decidualization process.ConclusionsThese results suggest that NDRG2 might play an important role in the process of decidualization during early pregnancy.

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Estrogen regulates the expression of Ndrg2 in astrocytes

Cited by 23 publications

References 40 publications

Regulation of astroglia by gonadal steroid hormones under physiological and pathological conditions

Regulation of astroglia by gonadal steroid hormones under physiological and pathological conditions

Astrocytic response to cerebral ischemia is influenced by sex differences and impaired by aging

Uterine NDRG2 expression is increased at implantation sites during early pregnancy in mice, and its down-regulation inhibits decidualization of mouse endometrial stromal cells

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