Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer

Walker, Graeme E.; MacLeod, Kenneth G.; Williams, Alistair; Cameron, David; Smyth, John F.; Langdon, Simon P.

doi:10.1016/j.ygyno.2007.05.009

Cited by 71 publications

(66 citation statements)

References 22 publications

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“…There are only a few studies that have investigated the effects of TGFBI on tumour cell function, and the knowledge about the role of TGFBI in ovarian cancer is still limited. Studies have shown that the level of TGFBI in ovarian cancer tissues is predictive of the disease response to the treatment with the aromatase inhibitor letrozole (Walker et al 2007) or the chemotherapeutic drug paclitaxel (Ahmed et al 2007). Our previous findings suggest that TGFBI is downregulated in ovarian cancer and that high concentration of TGFBI induced ovarian cancer cell death, which supports a tumour suppressor role (Ween et al 2010).…”

Section: Role Of Tgfbi In Ovarian Cancermentioning

confidence: 62%

WOMEN IN CANCER THEMATIC REVIEW: Ovarian cancer–peritoneal cell interactions promote extracellular matrix processing

Ricciardelli

Lokman

Ween

et al. 2016

Endocrine-Related Cancer

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Ovarian cancer has a distinct tendency for metastasising via shedding of cancerous cells into the peritoneal cavity and implanting onto the peritoneum that lines the pelvic organs. Once ovarian cancer cells adhere to the peritoneal cells, they migrate through the peritoneal layer and invade the local organs. Alterations in the extracellular environment are critical for tumour initiation, progression and intra-peritoneal dissemination. To increase our understanding of the molecular mechanisms involved in ovarian cancer metastasis and to identify novel therapeutic targets, we recently studied the interaction of ovarian cancer and peritoneal cells using a proteomic approach. We identified several extracellular matrix (ECM) proteins including, fibronectin, TGFBI, periostin, annexin A2 and PAI-1 that were processed as a result of the ovarian cancerperitoneal cell interaction. This review focuses on the functional role of these proteins in ovarian cancer metastasis. Our findings together with published literature support the notion that ECM processing via the plasminogen-plasmin pathway promotes the colonisation and attachment of ovarian cancer cells to the peritoneum and actively contributes to the early steps of ovarian cancer metastasis.

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Section: Role Of Tgfbi In Ovarian Cancermentioning

confidence: 62%

WOMEN IN CANCER THEMATIC REVIEW: Ovarian cancer–peritoneal cell interactions promote extracellular matrix processing

Ricciardelli

Lokman

Ween

et al. 2016

Endocrine-Related Cancer

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“…However, the role of TFF3 in ovarian cancer has not been fully elucidated (13). In breast cancer cells, TFF3 expression is generally positively associated with mammary carcinoma of the estrogen receptor-positive subtype, and TFF3 was recently identified as a promoter of tumor angiogenesis (4).…”

Section: Discussionmentioning

confidence: 99%

Trefoil factor 3 expression in epithelial ovarian cancer exerts a minor effect on clinicopathological parameters

Hoellen

Kostara

Karn

et al. 2016

Molecular and Clinical Oncology

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Abstract. The role of trefoil factor 3 (intestinal) (TFF3) has been analyzed in numerous cancers, such as breast and gastrointestinal cancer, and has been associated with poor prognosis. However, the role of TFF3 in ovarian cancers is not clear. Expression analysis of TFF3 in 91 ovarian cancer patients was performed by immunohistochemistry of primary paraffin-embedded tumor samples. The results were scored according to staining intensity and percentage of positive tumor cells resulting in an immune-reactive score (IRS) of 0-12. These results were correlated with clinicopathological characteristics and survival. TFF3 expression in our patient cohort exhibited a tendency towards improved overall and progression-free survival (PFS). In TFF3-positive serous and high-grade serous ovarian cancers, the median PFS was 27.6 months [�� confi -�� confidence interval (CI): 0-55.7] vs. 15.2 months in TFF3-negative tumors (95% CI: 13.8-16.6) (P=0.183). The median overall survival was 53.9 months in TFF3-positive tumors (95% CI: Non-applicable) vs. 44.4 months in TFF3-negative cases (�� CI: 30.�-�8.3) (P= 0.36). TFF3 negativity was significantly associated with higher tumor grade (P=0.05). Based on our results, further studies are required in order to elucidate whether survival and chemosensitivity are affected by TFF3 expression in ovarian cancer.

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“…5). In consideration of the marked gene expression of PDZK1 in breast and ovarian cancers (Ghosh et al, 2000;Walker et al, 2007), the interaction between BCRP and PDZK1 could be a target for at least partially overcoming BCRP-mediated drug resistance in certain cancer cells.…”

Section: Discussionmentioning

confidence: 99%

PDZK1 Regulates Breast Cancer Resistance Protein in Small Intestine

Shimizu¹,

Sugiura²,

Wakayama³

et al. 2011

Drug Metab Dispos

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ABSTRACT:Transporter adaptor protein PDZK1 regulates several influx transporters for xenobiotics and nutrients in small intestine, and their expression on the apical membrane is diminished in pdzk1 gene knockout [pdzk1(؊/؊)] mice. In the present study, we initially attempted to use pdzk1(؊/؊) mice to functionally identify influx transporters responsible for intestinal absorption of cimetidine. Contrary to our expectation, the plasma concentration of cimetidine after oral administration to pdzk1(؊/؊) mice was higher than that in wild-type mice, and the double peaks of plasma concentration found in wild-type mice were not observed in pdzk1 (

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Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer

Cited by 71 publications

References 22 publications

WOMEN IN CANCER THEMATIC REVIEW: Ovarian cancer–peritoneal cell interactions promote extracellular matrix processing

WOMEN IN CANCER THEMATIC REVIEW: Ovarian cancer–peritoneal cell interactions promote extracellular matrix processing

Trefoil factor 3 expression in epithelial ovarian cancer exerts a minor effect on clinicopathological parameters

PDZK1 Regulates Breast Cancer Resistance Protein in Small Intestine

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