Estrogen Reduces Caspase-3 Expression in the Inner Ear of Guinea Pigs Exposed to Simulated Microgravity and Inboard Noises of Spaceship

Introduction There is only limited information from previous studies that suggest that auditory function may be influenced by hormones. Recent advances in the field have exposed the potential role of hormones in modulating the auditory system. Objective This study aims to investigate the relationship between menstrual cycle and outer hair cell function with audiological examination. Methods This is an analytic study with a cross-sectional design. The sampling was a systematic random sampling. We found 49 women with normal menstrual cycle and collected their data through interviews, physical examination, and examination of the ear, with otoscopic and other routine otorhinolaryngology examinations. We evaluated Tympanometry, distortion-product otoacoustic emissions (DPOAE), and pure tone audiometry. Results We found the audiometric threshold worse in the follicular phase than other phases at 4000 Hz of the right ear, and in the ovulation was found best than any other phases at 1000 Hz of the left ear with significant difference. We found significant difference of DPOAE between ovulation time and follicular phase at 3000 Hz and 1000 Hz in the left ear and between ovulation and luteal phased at 2000 Hz, 3000 Hz and 5000 Hz in the right ear and at 1000 Hz in the left ear with p < 0.05. Conclusion The result of this study showed that only a small part of audiometry threshold had a significant difference between each menstrual phase. In other words, we found no correlation between menstrual and audiometry threshold. Nonetheless, there is a correlation between menstrual cycle phase and DPOAE amplitude.

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“…Caspase-3 are pro-apoptotic agents which become a precursor to the hair cell apoptotic process in the cochlea upon noise exposure. 3 4 13 29 …”

Section: Discussionmentioning

confidence: 99%

Influence of Hormonal Changes on Audiologic Examination in Normal Ovarian Cycle Females: An Analytic Study

Adriztina

Adnan

Adenin

et al. 2015

Int Arch Otorhinolaryngol

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“…For example, Meltser et al [25] reported that estrogen-receptor beta (ERβ) can protect the auditory system from acoustic trauma in male and female mice. Wang et al [26] also demonstrated the protective role of estrogen in auditory function by injecting estradiol into male guinea pigs that were exposed to noise.…”

Section: Effects Of Noise Exposure On the Auditory Function Of Ovariementioning

confidence: 99%

Effects of Noise Exposure on the Auditory Function of Ovariectomized Rats with Estrogen Deficiency

Wang²,

Lau³

2016

Int Adv Otol

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OBJECTIVE:The benefits of estrogen for the auditory function of women depend on a number of factors. In this study, we aimed to examine the impact of noise trauma on the auditory function of ovariectomized rats with estrogen deficiency. MATERIALS and METHODS:Twenty-eight young, female Sprague-Dawley rats were assigned to three groups (OVX+N, OVX-N, Sham+N). Rats in the OVX+N group and the OVX-N group underwent bilateral ovariectomy (OVX); the OVX+N group alone was also exposed to white noise (N) of 115 dB SPL for 8 hours a day over 14 days. The Sham+N group consisted of rats with intact ovaries that were exposed to the same noise. The auditory function of all rats was measured before treatment and after noise exposure by the signal-to-noise ratio (SNR) of distortion-product otoacoustic emissions (DPOAE) and the threshold of auditory-evoked brainstem response (ABR). RESULTS:The Sham+N group (intact ovaries, noise-exposed) had worse auditory function than the OVX-N group (ovariectomy, no noise). The OVX+N group had decreased SNRs of DPOAE and increased ABR thresholds relative to the Sham+N group. CONCLUSION:Noise exposure may cause greater damage to auditory function when estrogen levels are low in females.

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Estrogen Reduces Caspase-3 Expression in the Inner Ear of Guinea Pigs Exposed to Simulated Microgravity and Inboard Noises of Spaceship

Cited by 2 publications

References 35 publications

Influence of Hormonal Changes on Audiologic Examination in Normal Ovarian Cycle Females: An Analytic Study

Influence of Hormonal Changes on Audiologic Examination in Normal Ovarian Cycle Females: An Analytic Study

Effects of Noise Exposure on the Auditory Function of Ovariectomized Rats with Estrogen Deficiency

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