Estrogen receptors regulate innate immune cells and signaling pathways

Kovats, Susan

doi:10.1016/j.cellimm.2015.01.018

Cited by 770 publications

(657 citation statements)

References 86 publications

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“…Abnormal ER signaling leads to development of a variety of diseases, such as cancer, metabolic and cardiovascular disease, neurodegeneration, inflammation (8), and osteoporosis (3). Chemical binding to the ER is one of the significant mechanisms interfering with process of reproduction (9, 10).…”

Section: Discussionmentioning

confidence: 99%

Estrogen Receptor Binding Affinity of Food Contact Material Components Estimated by QSAR

Sosnovcová¹,

Rucki²,

Bendová³

2016

Cent Eur J Public Health

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SUMMARY Aim:The presented work characterized components of food contact materials (FCM) with potential to bind to estrogen receptor (ER) and cause adverse effects in the human organism.Methods: The QSAR Toolbox, software application designed to identify and fill toxicological data gaps for chemical hazard assessment, was used. Estrogen receptors are much less of a lock-and-key interaction than highly specific ones. The ER is nonspecific enough to permit binding with a diverse array of chemical structures. There are three primary ER binding subpockets, each with different requirements for hydrogen bonding.Results: More than 900 compounds approved as of FCM components were evaluated for their potential to bind on ER. All evaluated chemicals were subcategorized to five groups with respect to the binding potential to ER: very strong, strong, moderate, weak binder, and no binder to ER. In total 46 compounds were characterized as potential disturbers of estrogen receptor.Conclusion: Among the group of selected chemicals, compounds with high and even very high affinity to the ER binding subpockets were found. These compounds may act as gene activators and cause adverse effects in the organism, particularly during pregnancy and breast-feeding. It should be considered to carry out further in vitro or in vivo tests to confirm their potential to disturb the regulation of physiological processes in humans by abnormal ER signaling and subsequently remove these chemicals from the list of approved food contact materials.

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Section: Discussionmentioning

confidence: 99%

Estrogen Receptor Binding Affinity of Food Contact Material Components Estimated by QSAR

Sosnovcová¹,

Rucki²,

Bendová³

2016

Cent Eur J Public Health

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“…Estrogen effects are mediated through two isoforms of estrogen receptors (ER)-ERα and ERβ. Two isoforms have been identified for the progesterone receptor (PR) as well-PRA and PRB, while androgen receptor has no variants and binds both testosterone and 5α-dihydrotestosterone [5][6][7][8].…”

Section: Sex Hormones and The Immune Systemmentioning

confidence: 99%

Sex Hormones and Multiple Sclerosis

Trenova¹

2016

Trending Topics in Multiple Sclerosis

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Experimental and clinical data about the influence of sex hormones on the course of multiple sclerosis (MS) grow rapidly during the past two decades. Estrogens, progesterone, and androgens have been shown to ameliorate experimental autoimmune encephalomyelitis (EAE) in animals, and pregnancy in women is associated with a dramatic reduction in disease activity. Immunomodulatory and neuroprotective properties of sex hormones are the most probable underlying mechanisms, creating a background for testing similar hormonal treatments in humans. Several pilot studies in this field present promising results, but larger trials are necessary to identify the adverse events and to estimate precisely the place of sex steroids in multiple sclerosis therapeutic strategies.The objective of this chapter is to summarize the recent advances in the research about the effects of sex steroids in EAE and MS and to create a ground for the development of more powerful treatments in the future.

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“…The study design included the following groups: 1) pregnant women (n=96) who were in their second trimester (weeks [16][17][18][19][20][21][22][23][24] or third trimester (weeks 25-34), 2) postpartum women (n=96) who were evaluated 6 months after delivery.…”

Section: Study Populationmentioning

confidence: 99%

“…They are able to modulate the activities of all the cells involved in the immune inflammatory response depending on their concentration. 16,17 Studies suggested that progesterone and estrogen have both immune-stimulatory and immune-suppressive effects depending on the concentration. Table 1.…”

mentioning

confidence: 99%

Evaluation Of Salivary IL-1Beta And IL-6 Levels In Pregnant And Postpartum Women

Gümüş¹,

Öztürk²,

Belibasakis³

et al. 2016

EÜ Dişhek Fak Derg

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ÖZETAmaç: Gebelikte ortaya çıkan fizyolojik değişiklikler lokal enflamatuvar medyatörleri etkileyebilir ve periodontal enflamasyonun şiddetini arttırabilir. Çalışmamızda aynı kadında gebelikte ve doğum sonrasında tükürük IL-1beta (interlökin-1beta) ve IL-6 (interlökin-6) düzeylerinin incelenmesi ve periodontal hastalık şiddeti ile ilişkisinin değerlendirilmesi amaçlanmıştır. Yöntem: Toplam 96 gingivitis tanısı konan kadın çalışmaya dahil edilmiştir. Gebe kadınlar doğum sonrası 6. ayda tekrar değerlendirilmiş, gebe grubu ve doğum sonrası olmak üzere iki grup oluşturulmuştur. Tükürük IL-1beta ve IL-6 düzeyleri ELISA yöntemi ile belirlenmiştir. Parametreler arasında ki korelasyonlar Spearman's korelasyon analizi ile değerlendirilmiştir. Bulgular: Tükürük IL-1beta düzeyleri doğum sonrası grubunda gebe gruba göre anlamlı olarak düşük bulunmuştur (p=0.045). Doğum sonrası grupta IL-6 seviyeleri gebe grubundan anlamlı olarak yüksek düzeydedir (p<0.0001). Gebe grubunda IL-1beta seviyesi plak indeksi, kanama indeksi ve sondalama derinliği ile anlamlı pozitif korelasyon göstermektedir. Doğum sonrası grupta IL-6 düzeyleri plak ve kanama skorları ile pozitif korelasyondadır. Sonuç: Çalışmamızın bulgularına göre, lokal biyokimyasal parametreler gebelikten etkilenmektedir. Bu ilişkilerin anlaşılması diş hekimleri ve tıbbi uzmanlar açısından önem taşımaktadır. Anahtar Kelimeler: Tükürük, periodontal hastalık, gebelik ABSTRACT Introduction: Local inflammatory mediators could be affected from physiological changes in the pregnancy and exacerbate the periodontal inflammation. The aim of the present study was to evaluate pregnant and postpartum saliva levels of and

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Estrogen receptors regulate innate immune cells and signaling pathways

Cited by 770 publications

References 86 publications

Estrogen Receptor Binding Affinity of Food Contact Material Components Estimated by QSAR

Estrogen Receptor Binding Affinity of Food Contact Material Components Estimated by QSAR

Sex Hormones and Multiple Sclerosis

Evaluation Of Salivary IL-1Beta And IL-6 Levels In Pregnant And Postpartum Women

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