Estrogen Receptors in the Spinal Cord, Sensory Ganglia, and Pelvic Autonomic Ganglia

Papka, Raymond E.; Mowa, Chishimba Nathan

doi:10.1016/s0074-7696(03)31003-4

Cited by 47 publications

(43 citation statements)

References 200 publications

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“…The most likely candidates for sensory and pelvic autonomic ganglia are the ER␣ and ER␤ isoforms and perhaps the more recently identified estrogen G protein-coupled receptor GPR30 (40,42). It is known that GPR30 mediates a variety of estrogen-dependent kinase activation pathways and transcriptional responses as well as exhibiting potential for modifying vascular-related signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

17β-Estradiol restores excitability of a sexually dimorphic subset of myelinated vagal afferents in ovariectomized rats

Qiao

et al. 2009

American Journal of Physiology-Cell Physiology

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Qiao GF, Li BY, Lu YJ, Fu YL, Schild JH. 17␤-Estradiol restores excitability of a sexually dimorphic subset of myelinated vagal afferents in ovariectomized rats. Am J Physiol Cell Physiol 297: C654 -C664, 2009. First published July 1, 2009 doi:10.1152/ajpcell.00059.2009.-We recently identified a myelinated vagal afferent subpopulation (Ah type) far more prevalent in female than male rats and showed that this difference extends to functionally specific visceral sensory afferents, baroreceptors of the aortic arch. Excitability of myelinated Ah-type afferents is markedly reduced after ovariectomy (OVX). Here we tested the hypothesis that 17␤-estradiol can selectively restore excitability of these sex-specific vagal afferents. Acutely isolated vagal afferent neurons (VGN) from intact and OVX adult female rats were used with patch-clamp technique and current-clamp protocols to assess the effect of acute application of 17␤-estradiol on neuronal excitability. At over physiologically relevant 17␤-estradiol concentrations for rat (1-10 nM) excitability of myelinated Ah-type vagal afferents is restored to discharge frequencies comparable to those in intact females, albeit with some interesting differences related to burst and sustained patterns of neuronal discharge. Restoration of excitability occurs within 3 min of hormone application and is stereo specific, because 1,000 nM 17␣-estradiol fails to alter excitability. Furthermore, activation of G protein-coupled estrogen receptor GPR30 with highly selective agonist G-1 similarly restores excitability of Ah-type afferents. The effectiveness of 17␤-estradiol and G-1 is completely eliminated by application of high-affinity estrogen receptor ligand ICI-182,780. 17␤-Estradiol conjugated with BSA is ϳ70% as effective as 17␤-estradiol alone in restoring Ah-type VGN excitability. These data support our conclusions that the cellular mechanisms leading to rapid restoration of neuronal excitability of myelinated Ah-type VGN after OVX occur, at least in part, via membrane-bound estrogen receptors. We contend that recovery of high-frequency discharge at physiologically relevant 17␤-estradiol concentrations implies that this unique subtype of low-threshold myelinated vagal afferent may account for some of the sex-related differences in visceral organ system function. Sex differences in cardiovascular and gastrointestinal function and the potential role of GPR30 in modulation of sex-specific myelinated Ah-type vagal afferents are discussed. sensory afferent; visceral afferent; estrogen receptor; GPR30; ovariectomy VISCERAL AFFERENTS with cell bodies in the vagal ganglia innervate a functionally diverse range of organs associated with the cardiovascular, gastrointestinal, and pulmonary systems. Vagal afferent mediation of the reflexogenic properties of the autonomic nervous system (ANS) in addition to visceral sensation is well recognized (for review see Ref. 55). Because the peripheral sensory terminals can be influenced by a wide range of endogenous chemicals released as a consequenc...

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Section: Discussionmentioning

confidence: 99%

17β-Estradiol restores excitability of a sexually dimorphic subset of myelinated vagal afferents in ovariectomized rats

Qiao

et al. 2009

American Journal of Physiology-Cell Physiology

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“…In their review, Papka and Mowa (2003) show the presence of oestrogen receptors in spinal cord neurons and sensory and autonomic ganglionic neurons in sites that are associated with innervation of the female reproductive organs, and explain the role that oestrogen may play in these neurons and their circuits. On the other hand, Chen and Hua (1987) have shown the fast effect of glucocorticoid on neuronal membrane of hippocampal slices of rat and isolated coeliac ganglion of guinea pig.…”

Section: Discussionmentioning

confidence: 99%

Involvement of the coeliac ganglion in the luteotrophic effect of androstenedione in late pregnant rats

Casais¹,

Delgado²,

Sosa³

et al. 2006

Reproduction

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Using the ex vivo coeliac ganglion-superior ovarian nerve-ovary system at the end of pregnancy when luteal regression starts, we investigated whether, when administered systemically or when added directly to the ganglion compartment, androstenedione (A 2 ) can reverse such regression, and whether the neural (noradrenaline (NA)) and endocrine (A 2 ) joint action modifies the release of ovarian progesterone. The experimental groups were as follows: group 1 -A 2 injected systemically 48 h before incubation of the system (A 2 ) s ; group 2 -A 2 directly added to the ganglion compartment (A 2 ) g ; group 3 -A 2 injected 48 h before incubation of the system with NA in the ganglion compartment (A 2 1 NA); group 4 -A 2 plus NA added to the ganglion compartment (NA 1 A 2 ) g . The controls were ex vivo systems without treatment (control), and with the addition of NA alone in the ganglion compartment (NA). The results were as follows. For (A 2 ) s versus control, progesterone increased on days 19 and 21 of pregnancy at all the studied times and only at 180 min on day 20. For (A 2 1 NA) versus (A 2 ) s , progesterone increased on days 19 and 21. For (A 2 1 NA) versus NA, progesterone increased at all the studied times on days 19 and 21 and at 180 min on day 20. For (A 2 ) g versus control, progesterone significantly increased every pregnancy day. For (NA 1 A 2 ) g versus (A 2 ) g , progesterone decreased at 120 and 180 min on day 19. For (NA 1 A 2 ) g versus NA, progesterone increased on days 20 and 21. We can conclude that A 2 can reverse the functional regression of the corpus luteum either systemically or, what is more surprising, when directly added to the coeliac ganglion, whose action on the ovary is exerted via superior ovarian nerve.

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“…10 With regard to other sites that may respond to estrogen, autonomic and sensory neurons are known to express ERs. 11 Particularly, ERs have been identified in pelvic parasympathetic ganglionic neurons that innervate pelvic organs including the urinary bladder. 11 -13 The above findings indicate that ER-containing parasympathetic neurons are likely to be targets for circulating estrogen and estrogen may directly influence cholinergic neurotransmission in the urinary bladder.…”

Section: Introductionmentioning

confidence: 99%

The effects of ovariectomy and estrogen replacement on acetylcholine release from nerve fibres and passive stretch‐induced acetylcholine release in female rat bladder

Yoshida

Aikawa

Yoshimura

et al. 2007

Neurourology and Urodynamics

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Our findings showed that as a results of estrogen deficiency, Ach release from nerve fibres decreased, suggesting that this reduction of Ach released from cholinergic nerves may cause the decrease in detrusor contractility. Furthermore, this study also demonstrated that stretch-induced TTX-insensitive Ach release was increased by ovariectomy. This may be a contributing factor to the development of overactive bladder in elderly women.

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Estrogen Receptors in the Spinal Cord, Sensory Ganglia, and Pelvic Autonomic Ganglia

Cited by 47 publications

References 200 publications

17β-Estradiol restores excitability of a sexually dimorphic subset of myelinated vagal afferents in ovariectomized rats

17β-Estradiol restores excitability of a sexually dimorphic subset of myelinated vagal afferents in ovariectomized rats

Involvement of the coeliac ganglion in the luteotrophic effect of androstenedione in late pregnant rats

The effects of ovariectomy and estrogen replacement on acetylcholine release from nerve fibres and passive stretch‐induced acetylcholine release in female rat bladder

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