Estrogen Receptors Alpha (ESR1) and Beta (ESR2) Are Expressed in Circulating Human Lymphocytes

Estrogenic Hormone Modulation Abrogates Changes in Red Blood Cell Deformability and Neutrophil Activation in Trauma Hemorrhagic Shock

“…That is, tissues such as the lung that are ER- β dominant had less neutrophil sequestration when the animals received the ER- β agonist, whereas the liver, which is an ER- α -dominant organ, had less neutrophil sequestration when they received the ER- α agonist 26. Furthermore, our observation that one of the ERs seems more important in limiting neutrophil activation than the other, although both are expressed, also seems to be seen in lymphocytes, as lymphocytes seem to express both ER- α and ER- β 27; yet, the ER- α agonist, but not the ER- β agonist, limited trauma hemorrhage-induced immune alterations 7…”

Low-dose mifepristone increases uterine natural killer cell cytotoxicity and perforin expression during the receptive phase

“…The presence of intracellular E receptors (ER) in human immune cells is a controversial issue (32,35,36), whereas ER surface membrane expression has scarcely been examined. Increasing evidence (37) indicates the existence of membrane-localized ERs, structurally similar to intracellular ERs, which initiate rapid events leading to the activation of various protein kinase cascades.…”

Estrogen receptor profiles in human peripheral blood lymphocytes

“…differences in antibody specificity) and to the criteria for donor selection (i.e. gender, age, menstrual cycle phases) [12][13][14][15][16][17]. Conversely, the presence and the functional significance of mER have scarcely been explored [18].…”