Estrogen receptors alpha (ERα) and beta (ERβ): Subtype-selective ligands and clinical potential

Paterni, Ilaria; Granchi, Carlotta; Katzenellenbogen, John A.; Minutolo, Filippo

doi:10.1016/j.steroids.2014.06.012

Cited by 587 publications

(445 citation statements)

References 163 publications

Supporting

Mentioning

399

Contrasting

Unclassified

Order By: Relevance

“…This is especially true for steroid hormones 168,169 . Along these lines, a topic of great interest and translational potential is that of the interplay between their influence and epigenetic reprogramming of cells, with a well known interplay between ER and AR function and key histone and DNA modifying enzymes 13 , which can be targeted by a large battery of natural and synthetic compounds 170 .…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Sexual dimorphism in cancer

et al. 2016

View full text Add to dashboard Cite

The incidence of many cancer types is significantly higher in the male than female populations, with associated differences in survival. Occupational and/or behavioral factors are well known underlying determinants. However, cellular/molecular differences between the two sexes are also likely to be important. We are focusing here on the complex interplay that sexual hormones and sex chromosomes can have in intrinsic control of cancer initiating cell populations, tumor microenvironment and systemic determinants of cancer development like the immune system and metabolism. A better appreciation of these differences between the two sexes could be of substantial value for cancer prevention as well as treatment.3 Introduction (Epidemiology)

show abstract

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Sexual dimorphism in cancer

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Experimental studies have suggested that estradiol interferes with PPARG action and, consequently, with adipogenesis, by inhibiting adipocytic differentiation (7). Moreover, the relation between ER and inflammation has been described (5,8), with evidence that the regulation of pro-inflammatory cytokines expression by corticosteroids might be mediated by ERA and not by glucocorticoid receptor (GR) (9). These reports reinforce the hypothesis that ER, and particularly ERA, influences GO pathogenesis.…”

Section: Introductionmentioning

confidence: 68%

“…Although still controversial, the immunosuppressive role of estrogen in autoimmune diseases has been regarded as important (14). Thus, among the nuclear receptors possibly involved in GO, there are ERs, which have been associated with inflammatory processes, whether they are autoimmune or not (5,8). Although the mechanisms involved have not been elucidated yet, several factors seem to participate, such as, for instance, the IGF-1, which would exert an anti-inflammatory action mainly through ER, particularly ERA (15).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Gene expression of estrogen receptor-alpha in orbital fibroblasts in Graves’ ophthalmopathy

Cury

Oliveira

Síbio

et al. 2015

Arch. Endocrinol. Metab.

View full text Add to dashboard Cite

SUMMARYGraves' ophthalmopathy (GO) is one of the most severe clinical manifestations of Graves' disease (GD), and its treatment might involve high-dose glucocorticoid therapy. The higher incidence of GO among females, and the reported association between polymorphisms of estrogen receptor (ER) and GD susceptibility have led us to question the role of estrogen and its receptor in GO pathogenesis. We, thus, assessed estrogen receptor-alpha (ERA) gene expression in cultures of orbital fibroblasts from a patient with GO before (controls) and after treatment with 10 nM and 100 nM dexamethasone (DEX). Orbital fibroblasts showed ERA gene expression. In the cells treated with 10 nM and 100 nM DEX, ERA gene expression was, respectively, 85% higher and 74% lower, than in the control group. We concluded that ERA gene expression is found in the orbital fibroblasts of patient with GO, which may be affected by glucocorticoids in a dose-related manner. Arch Endocrinol Metab. 2015;59(3):273-6

show abstract

“…Dietary supplements containing high levels of isoflavonoid phytoestrogens are now widely available [6]. Isoflavone usage has increased because of the correlations between the high soy isoflavone levels in Asian diets and the reduced incidence of coronary heart disease as well as prostate, colon and breast cancers which suggest a possible protective effect of isoflavones [7]. Other potential beneficial aspects of soy consumption include the prevention of osteoporosis as well as hormone replacement therapy in menopause [7].…”

Section: Introductionmentioning

confidence: 99%

Effects of Post-Weaning Consumption of Soy Isoflavones on Prepubertal and Postpubertal Serum Levels of Some Reproductive Hormones of Male Wistar Rats

Godfrey¹,

Daniel²,

Sulaiman³

et al. 2017

ARSci

View full text Add to dashboard Cite

Chemically, soy contains a group of phytoestrogens called isoflavones, predominantly genistein and daidzein. The aim of the present study was to determine the effects of post weaning consumption of dietary soy isoflavones on prepubertal and postpubertal serum levels of some reproductive hormones of male Wistar rats. The study involved investigating the effects of different doses of isoflavones in the diet. Male rats were weaned on either soy isoflavone free diet or on isoflavone containing diets, formulated by adding increasing amounts of Novasoy, a commercially available isoflavone supplement to the isoflavone free diet to give varying concentrations of isoflavones. Three isoflavone containing diets were used and these had 74.5, 235.6 and 1046.6 mg total isoflavones/kg pelleted diet. These diets represented the isoflavone concentration lower, equal to and more than that found in soy-based infant formulas respectively. The results obtained showed that; administration of low doses soy isoflavones (74.5 mg/kg) produced significant (p < 0.05) increase in serum Antimullerian Hormone levels both in prepubertal and post pubertal rats, when compared to the control groups. Administration of moderate doses of isoflavones (235.6 mg/kg) produced significant (p < 0.05) increase in serum levels of Antimullerian Hormone and Inhibin in both prepubertal and post pubertal rats when compared to the control groups. Administration of high doses of isoflavones (1046.6 mg/kg) produced significant (p < 0.05) increase in serum levels of Inhibin in both prepubertal and post pubertal rats when compared to the control groups. From this study, it was concluded that post-weaning consumption soy isoflavones produced significant changes in How to cite this paper: Godfrey, S., Daniel, E.E., Oluwadare, S.S. and Yovani, B. 12serum Inhibin and Antimullerian Hormone both in prepubertal and post pubertal male Wistar rats and the changes were dose dependent.

show abstract

Estrogen receptors alpha (ERα) and beta (ERβ): Subtype-selective ligands and clinical potential

Cited by 587 publications

References 163 publications

Sexual dimorphism in cancer

Sexual dimorphism in cancer

Gene expression of estrogen receptor-alpha in orbital fibroblasts in Graves’ ophthalmopathy

Effects of Post-Weaning Consumption of Soy Isoflavones on Prepubertal and Postpubertal Serum Levels of Some Reproductive Hormones of Male Wistar Rats

Contact Info

Product

Resources

About