Estrogen receptor inhibits interleukin-6 gene expression by disruption of nuclear factor κB transactivation

Liu, Hui; Liu, Kenian; Bodenner, Donald

doi:10.1016/j.cyto.2004.12.008

Cited by 82 publications

(62 citation statements)

References 44 publications

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“…It has been postulated that estrogens exert their effect on bone not only by direct action per se, but also by inhibiting IL-6 gene expression. A similar relationship between androgen and IL-6 gene expression also exists [51]. The decline in ovarian function is associated with decreased OPG production and spontaneous increases in proinflammatory and pro-osteoclastic cytokines such as IL-6, TNF-α, and IL-1 [32,52,53].…”

Section: Ageing and Osteoporosis: Immunological Linksmentioning

confidence: 82%

Osteoporosis, Inflammation and Ageing

Ginaldi

Mengoli

Martinis

2009

Handbook on Immunosenescence

117

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Osteoporosis is a condition characterized by low bone mass and increased bone fragility, putting patients at risk of fractures, which are major causes of morbidity substantially in older people. Osteoporosis is currently attributed to various endocrine, metabolic and mechanical factors. However, emerging clinical and molecular evidence suggests that inflammation also exerts significant influence on bone turnover, inducing osteoporosis. Numerous proinflammatory cytokines have been implicated in the regulation of osteoblasts and osteoclasts, and a shift towards an activated immune profile has been hypothesized as important risk factor. Chronic inflammation and the immune system remodelling characteristic of ageing, as well as of other pathological conditions commonly associated with osteoporosis, may be determinant pathogenetic factors. The present article will review the current perspectives on the interaction between bone and immune system in the elderly, providing an interpretation of osteoporosis in the light of inflamm-ageing.

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Section: Ageing and Osteoporosis: Immunological Linksmentioning

confidence: 82%

Osteoporosis, Inflammation and Ageing

Ginaldi

Mengoli

Martinis

2009

Handbook on Immunosenescence

117

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“…Adipose tissue is involved in production of cytokines, key elements in inflammation signaling [31,32]; chronic inflammation is seen as being a key element in insulin-induced obesity [33,34]. Interleukin 6 (IL-6), a pleiotropic cytokine, produced by the stroma of adipose tissue [35,36], has multiple and opposing effects on various tissues [37] and is higher among obese individuals [35,36] Although it is inhibited by androgens, estrogen, and HRT [37][38][39][40], it suppresses aromatase and impairs estrogen biosynthesis [41]. Most prior studies have shown among post-menopausal women not using HRT that breast cancer risk associated with obesity is increased, while among women using HRT, no increased risk with obesity is observed [7].…”

Section: Discussionmentioning

confidence: 99%

Body size, weight change, fat distribution and breast cancer risk in Hispanic and non-Hispanic white women

Slattery

Sweeney

Edwards

et al. 2006

Breast Cancer Res Treat

129

190

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“…Gender and its specific hormones are known to influence the immune system, with estrogens as enhancers of the humoral immunity and androgens and progesterone as natural immunesupressors. Estradiol acts to inhibit pro-inflammatory cytokine gene expression, NF-κB binding, and production of proinflammatory cytokines (Deshpande et al 1997;Liu et al 2005;Ray et al 1997). Thus, the increased inflammatory reactivity such as increased serum IL-6 and cytokine levels in unstimulated PBMC supernatant among post-menopausal women may be related to lower circulating levels of reproductive hormones.…”

Section: Discussionmentioning

confidence: 99%

Effects of aging and menopause on serum interleukin-6 levels and peripheral blood mononuclear cell cytokine production in healthy nonobese women

Kim

Chae

Paik

et al. 2011

AGE

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Inappropriate interleukin-6 production is thought to play a role in the development of several age-related conditions including atherosclerosis. This study aimed to determine whether aging affects circulating interleukin-6 (IL-6) levels. Healthy, nonobese women (n = 208, 44.5 ± 0.70 years, 22.4 ± 0.17 kg/m 2 ) were categorized into four age groups (22-31, 32-41, 42-51, and 52-63 years; crosssectional study). Cytokine levels in serum and those produced from peripheral blood mononuclear cell (PBMC) were measured. The oldest group had the highest circulating levels of IL-6 and oxidized lowdensity lipoprotein (ox-LDL) and higher PBMC production of IL-6, tumor necrosis factor-α (TNF-α), and interleukin-1 alpha (IL-1β). Additionally, significant interactions between age and menopause were found for serum IL-6 (P=0.024), and TNF-α (P= 0.011) and IL-1β (P<0.001) produced from PBMCs. Serum IL-6 levels positively correlated with age, waist-hip ratio (WHR), systolic blood pressure, circulating levels of TNF-α, IL-1β, and ox-LDL, and urinary 8-epi-prostaglandin F 2 α. Multiple stepwise AGE (2012) 34:415-425

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Estrogen receptor inhibits interleukin-6 gene expression by disruption of nuclear factor κB transactivation

Cited by 82 publications

References 44 publications

Osteoporosis, Inflammation and Ageing

Osteoporosis, Inflammation and Ageing

Body size, weight change, fat distribution and breast cancer risk in Hispanic and non-Hispanic white women

Effects of aging and menopause on serum interleukin-6 levels and peripheral blood mononuclear cell cytokine production in healthy nonobese women

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