“…Vikhanskaya et al (1998) reported that the inactivation of p53 is susceptible to Paclitaxel in ovarian cancer (Rouzier et al, 2005), and Reinecke et al (2000a, b) described the expression and function of P-glycoprotein in renal cell carcinoma. Moreover, the overexpression of antiapoptotic genes (Wang et al, 2005), the upregulation of cyclin A (Takahashi et al, 2005), the overexpression of oestrogen receptor (Dougherty et al, 2004), and the reduced expression of tau (Rouzier et al, 2005) have all been reported as Paclitaxel susceptibility markers in breast cancer. As for colorectal cancers, the expression of MDR-1, bcl-2, and bax each contribute to Paclitaxel sensitivity (Sharma et al, 2000).…”