Estrogen receptor (ER) agonists and androgen receptor (AR) antagonists in effluents from Norwegian North Sea oil production platforms

Tollefsen, Knut-Erik; Harman, Christopher; Smith, Andy; Thomas, Kevin V.

doi:10.1016/j.marpolbul.2006.07.012

Cited by 50 publications

(46 citation statements)

References 19 publications

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“…There were few reports on androgen receptor antagonists in the waste water samples. Tollefsen et al (2007) firstly reported that androgen receptor antagonists were detected at concentrations of between 20 and 8,000 lg of flutamide equivalents/L in effluents from Norwegian North Sea oil production platforms, which were higher than the concentrations we have determined in effluent water. Some environmental contaminants such as vinclozolin, bisphenol A and butyl benzyl phthalate, which A extract of influent, B extract of effluent after sand filter treatment, C extract of effluent from train1, D extract of effluent from train2, E 2 17b-Estradiol, OHT 4-hydroxytamoxifen, T 3 3,3 0 ,5-triiodo-L-thyronine, ND not detection are usually detected in the waste water, have all been shown to be anti-androgens (Sohoni and Sumpter 1998).…”

Section: Resultscontrasting

confidence: 76%

Analysis of Environmental Endocrine Disrupting Activities Using Recombinant Yeast Assay in Wastewater Treatment Plant Effluents

Wang

et al. 2010

Bull Environ Contam Toxicol

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A battery of in vitro recombinant yeast bioassays was conducted to assess the estrogen receptor, androgen receptor, progesterone receptor and thyroid receptor ant/agonistic activities of effluents collected from Datansha wastewater treatment plant (WWTP), furthermore to evaluate the removal efficiencies of endocrine disrupting chemicals in the WWTP. The results showed that estrogenic, anti-androgenic, anti-progesteronic and anti-thyroidic activities were observed in influent. The removal efficiencies of these compounds were more than 80%, which suggested that the present wastewater treatment processes were good enough to remove most of all kinds of endocrine disruption chemicals.

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Section: Resultscontrasting

confidence: 76%

Analysis of Environmental Endocrine Disrupting Activities Using Recombinant Yeast Assay in Wastewater Treatment Plant Effluents

Wang

et al. 2010

Bull Environ Contam Toxicol

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“…No AR antagonistic activity was detected after the sludge from Changping STP was composted (S9), which indicated high remove efficiency of AR antagonistic pollutants by this kind of treatment. Similar results were reported in the literatures that remarkable AR antagonistic activities were observed whereas few androgen agonists were detected [13,33]. Several studies demonstrated that a lot of polarized compounds were detected in the effluents of STPs.…”

Section: Androgen Receptor Activitysupporting

confidence: 90%

Evaluation of endocrine disruption and dioxin-like effects of organic extracts from sewage sludge in autumn in Beijing, China

Cao

et al. 2013

Front. Environ. Sci. Eng.

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Study on effective disposal and utilization of sewage sludge has recently been the target of growing interest in China. However, potential risks are associated with the use of sludge due to its contamination with toxic organics, heavy metals and pathogenic microorganisms. In this study, a screening assessment was conducted on sewage sludge samples collected from 17 different sewage treatment plants in Beijing, based on a batch of in vitro bioassays, including a set of recombinant gene yeast assays for endocrine disruption, and an ethoxy resorufin-Odeethylase (EROD) assay using H4IIE cells for aryl hydrocarbon receptor (Ah-R) agonistic activities. Our results suggested that moderate levels of estrogen receptor agonistic activities (0.9 ng E2$g -1 to 6.8 ng E2$g -1 , dw), but relative higher androgen receptor antagonistic activities (nd to 45%), progestin receptor antagonistic activities (nd to 80%) and Ah-R agonistic activities (1390 to 6740 pg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)$g -1 , dw) were found in sewage sludge samples. However, there were no significant correlations between the toxic effects of sewage sludge and the sewage treatment processes. In addition, the 17β-estradiol (E2) equivalent quantity (EEQ) level of the sewage sludge was increased after the composting treatment, whereas the 2,3,7,8-tetrachlorodibenzo-p-dioxin toxic equivalent quantity (TEQ) level of sewage sludge composted was much lower than that of sewage sludge.

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“…There have been few reports in the literature on anti-androgenic contaminants in wastewater samples. Tollefsen et al [40] reported high concentrations of anti-androgenic contaminants (i.e., between 20 and 8000 μg of flutamide-EQ$L -1 ) in effluents 3.54E-9 2.93E-9 2.52E-9 1.16E-9 8.17E-10…”

Section: Anti-androgenic Contaminantsmentioning

confidence: 99%

In vitro agonistic and antagonistic endocrine disrupting effects of organic extracts from waste water of different treatment processes

Rao

et al. 2013

Front. Environ. Sci. Eng.

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Effluents from wastewater treatment plant (WWTP) have been reported to have a broad spectrum of endocrine disrupting compounds (EDCs). The majority of studies have focused on the occurrence of estrogenic activity, while ignoring nuclear hormone receptors (NRs) pathways. In the present study, a battery of in vitro yeast bioassays and a cell bioassay, including antagonistic and agonistic effects on estrogen receptor (ER), androgen receptor (AR), progesterone receptor (PR), estrogenrelated receptor (ERR) and aryl hydrocarbon receptor (AHR), were conducted to evaluate the removal efficiencies of EDCs by different treatment processes of a WWTP located in Beijing. Estrogenic, anti-estrogenic, antiandrogenic, anti-progesteronic, anti-ERR and the activation of AHR activities were detected in samples from all treatment processes and the receiving water. The concentration of estrogenic contaminants with estradiol (E 2 ) equivalent concentrations ranged from 0.82 Â 10

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Estrogen receptor (ER) agonists and androgen receptor (AR) antagonists in effluents from Norwegian North Sea oil production platforms

Cited by 50 publications

References 19 publications

Analysis of Environmental Endocrine Disrupting Activities Using Recombinant Yeast Assay in Wastewater Treatment Plant Effluents

Analysis of Environmental Endocrine Disrupting Activities Using Recombinant Yeast Assay in Wastewater Treatment Plant Effluents

Evaluation of endocrine disruption and dioxin-like effects of organic extracts from sewage sludge in autumn in Beijing, China

In vitro agonistic and antagonistic endocrine disrupting effects of organic extracts from waste water of different treatment processes

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