2021
DOI: 10.3389/fendo.2021.650625
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Estrogen Receptor Beta Influences the Inflammatory p65 Cistrome in Colon Cancer Cells

Abstract: Inflammation is a primary component of both initiation and promotion of colorectal cancer (CRC). Cytokines secreted by macrophages, including tumor necrosis factor alpha (TNFα), activates the pro-survival transcription factor complex NFκB. The precise mechanism of NFκB in CRC is not well studied, but we recently reported the genome-wide transcriptional impact of TNFα in two CRC cell lines. Further, estrogen signaling influences inflammation in a complex manner and suppresses CRC development. CRC protective eff… Show more

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Cited by 4 publications
(5 citation statements)
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References 65 publications
(87 reference statements)
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“…Here, based on network analysis, the main targets of EAE were affiliated with the PI3K-AKT and MAPK signaling pathways, and these pathways may be involved in immune function, inflammation, and bone erosion. Furthermore, these pathways had many intersection genes, and the NF-κB signaling pathway was one of the key overlaps among them. Activation of the PI3K-AKT and MAPK pathways can trigger the NF-κB signaling pathway. Moreover, NF-κB plays an important role in immune function, inflammation, and cancer. After deduction by network pharmacology, molecular docking was used to explore the potential interaction between NF-κB and key constituents. Molecular docking results indicated good ligand–receptor binding interactions between NF-κB and key constituents.…”
Section: Discussionmentioning
confidence: 99%
“…Here, based on network analysis, the main targets of EAE were affiliated with the PI3K-AKT and MAPK signaling pathways, and these pathways may be involved in immune function, inflammation, and bone erosion. Furthermore, these pathways had many intersection genes, and the NF-κB signaling pathway was one of the key overlaps among them. Activation of the PI3K-AKT and MAPK pathways can trigger the NF-κB signaling pathway. Moreover, NF-κB plays an important role in immune function, inflammation, and cancer. After deduction by network pharmacology, molecular docking was used to explore the potential interaction between NF-κB and key constituents. Molecular docking results indicated good ligand–receptor binding interactions between NF-κB and key constituents.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, both isoforms are reported to have different functions in CRC. For instance, ER β was reported to exhibit a protective effect in CRC through its activation by estrogen [ 305 ]. It was observed that ER β exhibited contrasting results of p65 chromatin binding in HT-29 and SW480 cells.…”
Section: Nuclear Receptors In Colorectal Cancermentioning
confidence: 99%
“…In HT-29 cells, ER β diminished a significant portion of p65 chromatin binding, whereas in SW480 cells, it augmented p65 binding. This could be due to the appearance of new p65 binding sites in SW480 cells in the presence of ER β , resulting in distinct modulation of the p65 cistrome in both cell lines [ 305 ].…”
Section: Nuclear Receptors In Colorectal Cancermentioning
confidence: 99%
“…found that 17β-estradiol induced ERβ upregulation in colon cancer cells by activating p38/MAPK signal pathway ( 44 ). ERβ regulates p65 signaling in colon cells ( 45 ). Estradiol regulates miR-135b and mismatch repair gene MMR expression in colorectal cells via ERβ ( 46 ).…”
Section: Hormones and Their Receptors In Colorectal Cancer Cellsmentioning
confidence: 99%