Estrogen receptor beta and G protein-coupled estrogen receptor 1 are involved in the acute estrogenic regulation of arginine-vasopressin immunoreactive levels in the supraoptic and paraventricular hypothalamic nuclei of female rats

Lagunas, Natalia; Marraudino, Marilena; Amorim, M.; Pinos, Helena; Collado, Paloma; Panzica, Giancarlo; García‐Segura, Luis M.; Grassi, Daniela

doi:10.1016/j.brainres.2019.02.002

Cited by 14 publications

(16 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In gonadectomized male mice, exogenous estrogen significantly increased OT mRNA transcription and decreased VP mRNA transcription in the PVN of wild-type mice, while in ERβ-knockout mice, these effects disappeared completely 28. In ovariectomized female rats, acute estradiol administration significantly decreased VP immunoreactivity in the SON and PVN after 24 hours 86. Fetal exposure to higher testosterone resulted in a decrease in OT mRNA expression in the SON and PVN and an increase of VP mRNA expression in the SON and suprachiasmatic nuclei in adult rats, without sex differences 87.…”

Section: Discussionmentioning

confidence: 93%

Sexual dimorphism of oxytocin and vasopressin in social cognition and behavior

Lu¹,

Lai²,

Du³

et al. 2019

PRBM

View full text Add to dashboard Cite

The neuropeptides oxytocin (OT) and vasopressin (VP) are hormones that are known to mediate social behavior and cognition, but their influence may be sexdependent. This paper aims to provide a comprehensive review of the sex-related influence of OT and VP on social cognition, focusing on partner preference and sexual orientation, trust and relevant behaviors, memory modulation, and emotion regulation. Most studies have suggested that OT facilitates familiar-partner preference in both sexes, with females being more significant, increased trust in others, especially for male, enhanced memory in either sex, and reduced anxious emotion in males. However, VP-regulated social cognition has been less studied. Other relevant studies have indicated that VP facilitated familiar-partner preference, improved memory, induced empathy formation, increased positive-emotion recognition, and induced anxiety without any sex difference. However, there was a male preponderance among studies, and results were often too complex to draw firm conclusions. Clarifying the interplay between OT/ VP and sex hormones in the regulation of social cognition is necessary for further applications.

show abstract

Section: Discussionmentioning

confidence: 93%

Sexual dimorphism of oxytocin and vasopressin in social cognition and behavior

Lu¹,

Lai²,

Du³

et al. 2019

PRBM

View full text Add to dashboard Cite

show abstract

“…109 In vivo experiments showed that ERβ and GPER-1 co-regulate the effects of E2 on argininevasopressin immunoreactivity. 110 In human renal tubular epithelial cells, E2 leads to cell proliferation via ERα and GPER-1. 111 In vitro experiments showed that ERβ suppressed the transcriptional and oncogenic effects of ERα.…”

Section: Discussionmentioning

confidence: 99%

ERα, A Key Target for Cancer Therapy: A Review

Liu

Yao

2020

OTT

View full text Add to dashboard Cite

Estrogen receptor α (ERα) is closely associated with both hormone-dependent and hormone-independent tumors, and it is also essential for the development of these cancers. The functions of ERα are bi-faceted; it can contribute to cancer progression as well as cancer inhibition. Therefore, understanding ERα is vital for the treatment of those cancers that are closely associated with its expression. Here, we will elaborate on ERα based on its structure, localization, activation, modification, and mutation. Also, we will look at coactivators of ERα, elucidate the signaling pathway activated by ERα, and identify cancers related to its activation. A comprehensive understanding of ERα could help us to find new ways to treat cancers.

show abstract

“…Concerning the hypothalamus, it is known that GPER is involved in the estrogenic regulation of the number of arginine-vasopressin-immunoreactive neurons in the supraoptic and paraventricular nucleus of female rats [32]. Furthermore, the GPER-selective agonist G1 decreases ERK immunoreactivity and the number of NADPH diaphorase-positive cells in the supraoptic and paraventricular hypothalamic nuclei in female rats [31].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, GPER mediates estrogenic actions involving the hypothalamus, such as the control of food intake in male mice [26] and the regulation of sexual receptivity [27], and lordosis behavior in female rats [28][29][30]. Furthermore, GPER participates in the estrogenic regulation of arginine-vasopressin immunoreactivity, NADPH diaphorase expression, and ERK phosphorylation in the supraoptic and paraventricular hypothalamic nuclei of female rats [31,32]. These effects may be mediated by direct actions of estradiol on hypothalamic GPER receptors.…”

Section: Introductionmentioning

confidence: 99%

G Protein-Coupled Estrogen Receptor Immunoreactivity in the Rat Hypothalamus Is Widely Distributed in Neurons, Astrocytes, and Oligodendrocytes, Fluctuates during the Estrous Cycle, and Is Sexually Dimorphic

Marraudino¹,

Carrillo²,

Bonaldo³

et al. 2020

Neuroendocrinology

Self Cite

View full text Add to dashboard Cite

Introduction: The membrane-associated G protein-coupled estrogen receptor 1 (GPER) mediates the regulation by estradiol of arginine-vasopressin immunoreactivity in the supraoptic and paraventricular hypothalamic nuclei of female rats and is involved in the estrogenic control of hypothalamic regulated functions, such as food intake, sexual receptivity, and lordosis behavior. Objective: To assess GPER distribution in the rat hypothalamus. Methods: GPER immunoreactivity was assessed in different anatomical subdivisions of five selected hypothalamic regions of young adult male and cycling female rats: the arcuate nucleus, the lateral hypothalamus, the paraventricular nucleus, the supraoptic nucleus, and the ventromedial hypothalamic nucleus. GPER immunoreactivity was colocalized with NeuN as a marker of mature neurons, GFAP as a marker of astrocytes, and CC1 as a marker of mature oligodendrocytes. Results: GPER immunoreactivity was detected in hypothalamic neurons, astrocytes, and oligodendrocytes. Sex and regional differences and changes during the estrous cycle were detected in the total number of GPER-immunoreactive cells and in the proportion of neurons, astrocytes, and oligodendrocytes that were GPER-immunoreactive. Conclusions: These findings suggest that estrogenic regulation of hypothalamic function through GPER may be different in males and females and may fluctuate during the estrous cycle in females.

show abstract

Estrogen receptor beta and G protein-coupled estrogen receptor 1 are involved in the acute estrogenic regulation of arginine-vasopressin immunoreactive levels in the supraoptic and paraventricular hypothalamic nuclei of female rats

Cited by 14 publications

References 50 publications

<p>Sexual dimorphism of oxytocin and vasopressin in social cognition and behavior</p>

<p>Sexual dimorphism of oxytocin and vasopressin in social cognition and behavior</p>

<p>ERα, A Key Target for Cancer Therapy: A Review</p>

G Protein-Coupled Estrogen Receptor Immunoreactivity in the Rat Hypothalamus Is Widely Distributed in Neurons, Astrocytes, and Oligodendrocytes, Fluctuates during the Estrous Cycle, and Is Sexually Dimorphic

Contact Info

Product

Resources

About