Estrogen Receptor and the Development of Estrogenic Responses in Embryonic Chick Liver

Lazier, Catherine B.; Nadin-Davis, Susan A.; Elbrecht, Alex; Blue, Marie‐Luise; Williams, David L.

doi:10.1007/978-1-4615-7192-6_2

Cited by 4 publications

(3 citation statements)

References 40 publications

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“…Ontogeny of induction type II receptors. The developmental stage at which avian liver becomes estrogen responsive has been examined previously by monitoring the induction of the type I receptor after the administration of the hormone and activation of the apoVLDLII and vitellogenin genes (11,20). The results indicate that acquisition of the competence to express type I receptor and to activate the apoVLDLII gene occurs at approximately the same developmental stage, i.e., between days 7 and 9.…”

Section: Resultsmentioning

confidence: 99%

Long-Term Effects of Estrogen on Avian Liver: Estrogen-Inducible Switch in Expression of Nuclear, Hormone-Binding Proteins

Haché

Tam

Cochrane

et al. 1987

Molecular and Cellular Biology

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The stimulation of chicks or embryos with estrogen results in transient, hepatic expression of the vitellogenin gene, as well as long-term, propagatable alterations in the rapidity with which the gene can be reactivated. We examined the possibility that nuclear, type II estrogen-binding sites are involved in this long-term change in response characteristics. We demonstrate that the primary induction kinetics of type II sites in embryos and chicks correlated with the expression of the vitellogenin gene and that once their induction was triggered by estrogen, they accumulated, were propagated, and persisted for months after withdrawal of the hormone. We also show that their accumulation in the embryo was accompanied by prolonged expression of both the vitellogenin and very low-density apolipoprotein II genes, in the absence of elevated levels of type I receptor, and that the type II sites, like the classical receptor, appear to be preferentially associated with active or potentially active chromatin. Finally, we describe a regulatory mechanism, tested by computer modelling, that simulated the behavioral characteristics of these nuclear estrogen-binding sites and which may explain their role in mediating the long-term effects of estrogen.

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Section: Resultsmentioning

confidence: 99%

Long-Term Effects of Estrogen on Avian Liver: Estrogen-Inducible Switch in Expression of Nuclear, Hormone-Binding Proteins

Haché

Tam

Cochrane

et al. 1987

Molecular and Cellular Biology

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show abstract

“…As demonstrated previously (32) Ontogeny of induction type II receptors. The developmental stage at which avian liver becomes estrogen responsive has been examined previously by monitoring the induction of the type I receptor after the administration of the hormone and activation of the apoVLDLII and vitellogenin genes (11,20). The results indicate that acquisition of the competence to express type I receptor and to activate the apoVLDLII gene occurs at approximately the same developmental stage, i.e., between days 7 and 9.…”

Section: Methodsmentioning

confidence: 99%

“…However, the transcription of both can be activated in birds of either sex by pharmacological doses of estrogen. This can be accomplished at any stage after day 8 of embryogenesis in the case of the apoVLDLII gene, but to elicit detectable expression of the vitellogenin gene, the embryos must be at least 11 days old (11,20). In chicks or adult roosters, the genes respond rapidly to estrogen (mature mRNA being detectable within 30 min to 1 h of stimulation), but the initial rate of expression of both is relatively low.…”

mentioning

confidence: 99%

Long-term effects of estrogen on avian liver: estrogen-inducible switch in expression of nuclear, hormone-binding proteins.

Haché¹,

Tam²,

Cochrane³

et al. 1987

Mol. Cell. Biol.

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The stimulation of chicks or embryos with estrogen results in transient, hepatic expression of the vitellogenin gene, as well as long-term, propagatable alterations in the rapidity with which the gene can be reactivated. We examined the possibility that nuclear, type H estrogen-binding sites are involved in this long-term change in response characteristics. We demonstrate that the primary induction kinetics of type II sites in embryos and chicks correlated with the expression of the vitellogenin gene and that once their induction was triggered by estrogen, they accumulated, were propagated, and persisted for months after withdrawal of the hormone. We also show that their accumulation in the embryo was accompanied by prolonged expression of both the vitellogenin and very low-density apolipoprotein II genes, in the absence of elevated levels of type I receptor, and that the type II sites, like the classical receptor, appear to be preferentially associated with active or potentially active chromatin. Finally, we describe a regulatory mechanism, tested by computer modelling, that simulated the behavioral characteristics of these nuclear estrogen-binding sites and which may explain their role in mediating the long-term effects of estrogen.

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Role of Steroid Hormone Receptors in Development and Puberty

Greenstein

Adcock

1985

The Receptors

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Estrogen Receptor and the Development of Estrogenic Responses in Embryonic Chick Liver

Cited by 4 publications

References 40 publications

Long-Term Effects of Estrogen on Avian Liver: Estrogen-Inducible Switch in Expression of Nuclear, Hormone-Binding Proteins

Long-Term Effects of Estrogen on Avian Liver: Estrogen-Inducible Switch in Expression of Nuclear, Hormone-Binding Proteins

Long-term effects of estrogen on avian liver: estrogen-inducible switch in expression of nuclear, hormone-binding proteins.

Role of Steroid Hormone Receptors in Development and Puberty

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