Estrogen receptor alpha polymorphisms and the risk of prostate cancer development

Jurečeková, Jana; Babušíková, Eva; Kmet'ová, M. Sivonova; Kliment, J.; Dobrota, Dušan

doi:10.1007/s00432-015-1966-6

Cited by 6 publications

(1 citation statement)

References 27 publications

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“…Figure 3 summarises the difference in ERα and ERβ expression between non-cancerous and cancerous prostate tissue. Single nucleotide polymorphisms (SNPs) in the ER genes have been investigated and associations have been made between certain polymorphisms and the risk of prostate cancer (Holt et al 2013, Jurečeková et al 2015. In both studies, the genomes from histologically confirmed human prostate cancer samples were analysed using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP)-based analysis and compared with age-matched healthy control subjects.…”

Section: Oestrogen Receptors (Er) In the Prostatementioning

confidence: 99%

In touch with your feminine side: how oestrogen metabolism impacts prostate cancer

Rahman

Hofland

Foster

2016

Endocrine-Related Cancer

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Prostate cancer is the primary cancer in males, with increasing global incidence rates making this malignancy a significant healthcare burden. Androgens not only promote normal prostate maturity but also influence the development and progression of prostate cancer. Intriguingly, evidence now suggests endogenous and exogenous oestrogens, in the form of phytoestrogens, may be equally as relevant as androgens in prostate cancer growth. The prostate gland has the molecular mechanisms, catalysed by steroid sulphatase (STS), to unconjugate and utilise circulating oestrogens. Furthermore, prostate tissue also expresses enzymes essential for local oestrogen metabolism, including aromatase (CYP19A1) and 3β- and 17β-hydroxysteroid dehydrogenases. Increased expression of these enzymes in malignant prostate tissue compared with normal prostate indicates that oestrogen synthesis is favoured in malignancy and thus may influence tumour progression. In contrast to previous reviews, here we comprehensively explore the epidemiological and scientific evidence on how oestrogens impact prostate cancer, particularly focusing on pre-receptor oestrogen metabolism and subsequent molecular action. We analyse how molecular mechanisms and metabolic pathways involved in androgen and oestrogen synthesis intertwine to alter prostate tissue. Furthermore, we speculate on whether oestrogen receptor status in the prostate affects progression of this malignancy.

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Section: Oestrogen Receptors (Er) In the Prostatementioning

confidence: 99%