Estrogen receptor alpha and beta regulate actin polymerization and spatial memory through an SRC-1/mTORC2-dependent pathway in the hippocampus of female mice

Zhao, Yangang; He, Li; Zhang, Yuanyuan; Zhao, Jingming; Li, Zhi; Xing, Fang-Zhou; Liu, Mengying; Feng, Ziqi; Li, Wei; Zhang, Jiqiang

doi:10.1016/j.jsbmb.2017.08.003

Cited by 42 publications

(29 citation statements)

References 56 publications

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“…However, enhanced aromatase expression in astrocyes has been reported following brain injury in rats and also in the human PFC in the late stages of AD, suggesting that neuronal impairment can induce estrogen production as a glial protective mechanism against neuronal death (Veiga et al, 2004 ; Luchetti et al, 2011 ; Acaz-Fonseca et al, 2016 ). A recent report has shown decreased levels of aromatase in the hippocampus of aged female mice when compared to the levels detected in adult mice (Zhao et al, 2017 ). OVX also downregulates aromatase gene expression in the hippocampus of middle-aged rats (Sárvári et al, 2014 ).…”

Section: Sex Hormones and Brain Agingmentioning

confidence: 95%

Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair

Zárate

Stevnsner

Gredilla

2017

Front. Aging Neurosci.

207

147

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Aging is an inevitable biological process characterized by a progressive decline in physiological function and increased susceptibility to disease. The detrimental effects of aging are observed in all tissues, the brain being the most important one due to its main role in the homeostasis of the organism. As our knowledge about the underlying mechanisms of brain aging increases, potential approaches to preserve brain function rise significantly. Accumulating evidence suggests that loss of genomic maintenance may contribute to aging, especially in the central nervous system (CNS) owing to its low DNA repair capacity. Sex hormones, particularly estrogens, possess potent antioxidant properties and play important roles in maintaining normal reproductive and non-reproductive functions. They exert neuroprotective actions and their loss during aging and natural or surgical menopause is associated with mitochondrial dysfunction, neuroinflammation, synaptic decline, cognitive impairment and increased risk of age-related disorders. Moreover, loss of sex hormones has been suggested to promote an accelerated aging phenotype eventually leading to the development of brain hypometabolism, a feature often observed in menopausal women and prodromal Alzheimer’s disease (AD). Although data on the relation between sex hormones and DNA repair mechanisms in the brain is still limited, various investigations have linked sex hormone levels with different DNA repair enzymes. Here, we review estrogen anti-aging and neuroprotective mechanisms, which are currently an area of intense study, together with the effect they may have on the DNA repair capacity in the brain.

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Section: Sex Hormones and Brain Agingmentioning

confidence: 95%

Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair

Zárate

Stevnsner

Gredilla

2017

Front. Aging Neurosci.

207

147

View full text Add to dashboard Cite

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“…The F-actin to G-actin ratio was determined by Western blot as previously described by Zhao et al (33).…”

Section: F-actin/g-actin Ratio Measurementmentioning

confidence: 99%

A self‐organized actomyosin drives multiple intercellular junction disruption and directly promotes neutrophil recruitment in lipopolysaccharide‐induced acute lung injury

Chen

Yang

et al. 2018

FASEB j.

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Acute lung injury (ALI), with the hallmarks of vascular integrity disruption and neutrophil recruitment, is associated with high morbidity and mortality. Enhanced actomyosin assembly contributes to endothelial cell contact dysfunction. However, the roles and mechanisms of actomyosin assembly in ALI are not totally clear. We investigated the dynamic alterations and roles of actomyosin in ALI in vivo and in vitro models induced by LPS. Pulmonary levels of E-cadherin, vascular endothelial-cadherin, occludin, myosin phosphatase target subunit 1, and thymosin β4 were decreased, and the number and activity of neutrophils and the levels of actomyosin, p-ρ-associated protein kinase, p-myosin light-chain kinase, and profilin1 were increased within 3 d after LPS administration, and then, those alterations were recovered within the next 4 d, which was consistent with the alterations of lung histology, vascular permeability, edema, and serum levels of IL-6 and TNF-α. Direct or indirect inhibition of increased F-actin or myosin assembly ameliorated the reduction of intercellular junction molecules, the activation and migration of neutrophils, and the degree of lung injury. Moreover, neutrophil activation further promoted actomyosin assembly and aggravated lung injury. Conclusively, the enhancement of self-organized actomyosin contributes to alveolar-capillary barrier disruption and neutrophil recruitment in inflammatory response, which is a potential therapeutic target for ALI.-Chen, B., Yang, Z., Yang, C., Qin, W., Gu, J., Hu, C., Chen, A., Ning, J., Yi, B., Lu, K. A self-organized actomyosin drives multiple intercellular junction disruption and directly promotes neutrophil recruitment in lipopolysaccharide-induced acute lung injury.

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“…Moreover, estrogen bound to ERα induces transcription when linked to Sp1 in GCrich regions, but not when it is bound to ERβ [69,[92][93][94]. Overall, mechanisms involving estrogen-receptor complex signaling are vast, appear to be cell type specific, and can interact with various pathways including ras, Src and PI3 kinases, EGFR, IGF1, AP-1, STATs, ATF-2/c-Jun, Sp1, NF-κB, CREB, Elk-1, and many others [95][96][97][98][99][100][101][102][103][104][105][106][107][108][109][110].…”

Section: Estrogen Estrogen Receptors and Estrogen-receptor Signalingmentioning

confidence: 99%

The Relationship between Estrogen-Related Signaling and Human Papillomavirus Positive Cancers

2020

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High risk-human papillomaviruses (HPVs) are known carcinogens. Numerous reports have linked the steroid hormone estrogen, and the expression of estrogen receptors (ERs), to HPV-related cancers, although the exact nature of the interactions remains to be fully elucidated. Here we will focus on estrogen signaling and describe both pro and potentially anti-cancer effects of this hormone in HPV-positive cancers. This review will summarize: (1) cell culture-related evidence, (2) animal model evidence, and (3) clinical evidence demonstrating an interaction between estrogen and HPV-positive cancers. This comprehensive review provides insights into the potential relationship between estrogen and HPV. We suggest that estrogen may provide a potential therapeutic for HPV-related cancers, however additional studies are necessary.

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Estrogen receptor alpha and beta regulate actin polymerization and spatial memory through an SRC-1/mTORC2-dependent pathway in the hippocampus of female mice

Cited by 42 publications

References 56 publications

Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair

Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair

A self‐organized actomyosin drives multiple intercellular junction disruption and directly promotes neutrophil recruitment in lipopolysaccharide‐induced acute lung injury

The Relationship between Estrogen-Related Signaling and Human Papillomavirus Positive Cancers

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