Estrogen protection against coronary heart disease: Are the relevant effects of estrogen mediated through its effects on uterus – such as the induction of menstruation, increased bleeding, and the facilitation of pregnancy?

Paranjape, S.G.; Turankar, Avinash Vikram; Wakode, Santosh; Dakhale, Ganesh N.

doi:10.1016/j.mehy.2005.04.030

Cited by 7 publications

(6 citation statements)

References 18 publications

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“…151 This interaction of age with shift work and cardiovascular risk may be more evident when the protective cardiovascular effect of estrogen is lost after menopause. 152 In line with these findings, female nurses on night shifts were found to have 6 mm Hg higher systolic blood pressure during sleep 153 and to demonstrate a greater risk (OR 6.1) of being nondippers (<10% drop in systolic blood pressure during sleep) compared with day workers. 154 The cardiovascular impact of shift work on race as well as gender needs investigation, as women of African origin working night shifts were found to have an even greater risk (OR 7.1) of being nondippers than women of other races.…”

Section: Shift Work and Cancermentioning

confidence: 58%

Sleep and Health Consequences of Shift Work in Women

Chung

Wolf

Shapiro

2009

Journal of Women's Health

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Women constitute about half the work force, and women shift workers warrant special attention given the different physiological needs of women, their reproductive status, and the added burden of family responsibilities. There is increasing evidence that women have greater difficulty adjusting to shift work compared to their male counterparts and that sleep problems may in large part account for this difficulty. The purpose of this article is to review the existing literature to highlight the differential negative impact of shift work on sleep and other health issues in women and as part of a needs assessment to promote research in female shift workers by developing and prioritizing research questions in this field. The literature suggests that women shift workers report poor sleep quality and experience reproductive disturbances, an increased risk of breast cancer, and a greater risk of metabolic and cardiovascular disorders.

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Section: Shift Work and Cancermentioning

confidence: 58%

Sleep and Health Consequences of Shift Work in Women

Chung

Wolf

Shapiro

2009

Journal of Women's Health

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“…93.6% patients displayed some form of dyslipidemia out of which 70.6% were male and 29.3% were female thus indicating a higher incidence of dyslipidemia in males. Thus, a statistically significant difference occurs between genders in developing post-transplant dyslipidemia coinciding with the fact that chance of developing dyslipidemia in females is less since they are protected by natural estrogen hormones (P value = 0.0054) (Paranjape, 2005). Though dyslipidemia was observed in majority of the study population (93.6%), not all patients displayed elevations in all form of lipids.…”

Section: Discussionmentioning

confidence: 81%

A Study on Immunosuppressant Induced Dyslipidemia and Associated Chronic Graft Rejection in Renal Transplant Recipients

George¹,

Dhivya²

2016

J App Pharm Sci

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Dyslipidemia is a common complication of renal transplantation referred to as new onset dyslipidemia. Immune suppressants, in particular cyclosporine, the calcineurin inhibitor and others are known to cause dyslipidemia through non-competitive inhibition of sterol 27-dehydroxylase (CYP27A1). On the other hand, dyslipidemia has been found to be associated with higher graft rejection due to decrease in immune suppressant activity and direct graft destruction. Hence the study was designed to analyze the effect of dyslipidemia on chronic allograft rejection. Clinical and biochemistry reports of 142 renal transplant recipients were collected in designed case report forms. All statistical analysis was carried out using International Business Machine (IBM) Statistical Package for Social Sciences (SPSS) 17.0. Immunosuppressive therapy, comorbid diabetes and hypertension, age and serum creatinine were found to be the common predictors of dyslipidemia whereas as dyslipidemia, age and gender were found to be predictors of graft destruction and loss (P>0.05). Incidence of graft loss was found higher in dyslipidemic patients (P<0.05). Dyslipidemia is associated with higher incidence of graft loss and hence renal transplant recipients should be effectively managed with dose intense statin therapy or other safer immunosuppressants. This could increase graft survival rates.

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“…The number of female subjects in the study is higher than male subjects, because male subjects have higher chance of being diagnosed with CHD than females in this age group. As reported by Paranjape et al (2005) women in the age group of 20-50 are shown to have much less susceptibility to coronary heart disease and other atherosclerotic diseases as compared to men. The findings of this study also showed significantly higher calculated 10 years risk of CHD for male than female (P < 0.05).…”

Section: Figure 4 Use Of Aspirin According To Risk Stratificationmentioning

confidence: 79%

calculated-10-years-risk-of-chd-primary-preventive-measures-in-medical-ward-ppukm-university-kebangsaan-malaysia-medical-centre

Hashim

Beshir

2011

Mal J Pharm

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Coronary heart disease (CHD) is the leading cause of morbidity and mortality globally. Identification of common risk factors and risk stratification helps to prioritize primary preventive measures and hence can reduce this epidemic. This retrospective cross sectional study was carried out to assess the primary preventive measures according to 10 years CHD risk stratification. One hundred thirty (67 female and 63 female) middle aged (40-65 years) patients admitted to PPUKM's medical ward with no prior diagnosis of CHD were selected. Patient diagnosed with diabetes or hypertension related to pregnancy was excluded. The patients' medical record and order management system (OMS) were screened to obtain relevant demographic information, medical and medication history and related laboratory results. The Joint British Societies CHD risk prediction chart was used to calculate the 10 years CHD risk. Gender specific differences of 10 years calculated CHD risk, baseline measure of BP, cholesterol, weight, BMI, HbA1C level and number of patients who received primary preventive measures were used as outcome measures. Results showed that male patients had a significantly higher 10 years CHD risk than female (P < 0.05). Hypertension was the most prevalent risk factor followed by diabetes and dyslipidemia. About10% (n=6) of hypertensive patients with SBP≥160 mmHg and 32 (37%) diabetic patients did not receive antihypertensive therapy and lipid lowering therapy respectively. Hence, there is a need for further improvement in primary preventive measures for CHD.

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Estrogen protection against coronary heart disease: Are the relevant effects of estrogen mediated through its effects on uterus – such as the induction of menstruation, increased bleeding, and the facilitation of pregnancy?

Cited by 7 publications

References 18 publications

Sleep and Health Consequences of Shift Work in Women

Sleep and Health Consequences of Shift Work in Women

A Study on Immunosuppressant Induced Dyslipidemia and Associated Chronic Graft Rejection in Renal Transplant Recipients

calculated-10-years-risk-of-chd-primary-preventive-measures-in-medical-ward-ppukm-university-kebangsaan-malaysia-medical-centre

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