Estrogen-Progesterone Relationships in the Development of Secretory Endometrium

Good, Robert G.; Moyer, Dean L.

doi:10.1016/s0015-0282(16)36543-8

Cited by 55 publications

(11 citation statements)

References 11 publications

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“…Other secretory products produced under the influence of progesterone include glycogen and glycoproteins which are thought to cause the gland dilation that is observed in oestradiol/progesterone-treated tissue (Good & Moyer 1968). In guinea pigs, relaxin, the hormone responsible for preparation of the myometrium for parturition, is produced in response to sequential oestradiol and progesterone treatment (Larkin et al 1987).…”

Section: Discussionmentioning

confidence: 99%

Effect of steroid hormones on tissue remodelling and progesterone receptors in the uterus of seasonally anoestrous brushtail possums (Trichosurus vulpecula)

Sizemore¹,

Hurst²,

McLeod³

2004

Reproduction

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This study describes progesterone receptor (PR) location within uterine cells and associated morphological changes to the uterine luminal and glandular epithelium in seasonally anoestrous brushtail possums treated with oestradiol and/or progesterone. Twenty-four adult female possums (n 5 6/group) were treated with oestradiol, progesterone, oestradiol followed by progesterone or with the oil vehicle alone for 6-day periods. Uterine tissue was recovered, weighed and processed for light and transmission electron microscopy and for immunohistochemistry for PRs. Stereological techniques were used to quantify epithelial cell and constituent volumes for both luminal and glandular tissues. Plasma concentrations of oestradiol and progesterone were determined by radioimmunoassay. Mean uterine wet weights were significantly heavier (P < 0.001) following oestradiol/progesterone treatment and maximum gland dilation, cellular and stromal growth, maximum cell height, and cell and constituent volumes were recorded after this treatment regimen. Cell nuclei and debris were commonly observed in gland lumina, and nuclear PRs were found predominantly in stromal cells following oestradiol-only treatment. Sequential treatment with oestradiol and then progesterone caused a decline in the number of positively stained cells. Epithelial cells contained extensive secretory organelles and degenerating cells were common within the glands. Oestradiol treatment induced cell and cell constituent growth and promoted PR formation in anoestrous possum uterine tissue. Subsequent exposure to progesterone stimulated uterine tissues to reach maximum wet weights and led to the cellular maturation necessary to remodel the uterus in preparation for pregnancy.

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Section: Discussionmentioning

confidence: 99%

Effect of steroid hormones on tissue remodelling and progesterone receptors in the uterus of seasonally anoestrous brushtail possums (Trichosurus vulpecula)

Sizemore¹,

Hurst²,

McLeod³

2004

Reproduction

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“…Long-term administration of progesterone, however, causes disappearance of the glands with extensive decidualization of the stroma (Hisaw, 1950;see later). There is some evidence that estrogens augment the action of progesterone in initiating glandular secretion (Engle and Smith, 1938;Good and Moyer, 1968), but detailed analysis of its effect is not easy in women .…”

Section: Glandular Epitheliummentioning

confidence: 99%

The Implantation Reaction

Finn

1977

Biology of the Uterus

171

121

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Implantation involves the attachment of the blastocyst to the wall of the uterus with, in some cases, the embedding of the entire ovum in the uterine wall. Associated with it are very profound and characteristic changes in the endometrium both during preparation for implantation and following attachment of the blastocyst. In this chapter, the uterine changes that take place during preparation will be considered first and then the changes during the process of implantation. The former occur regularly and frequently throughout the life of most female mammals, whereas the latter are rarer events, especially in women. This division of the subject is also convenient for the consideration of the control mechanism involved. Whereas the preparative changes are largely directed by the varying levels of the hormones secreted by the ovary, once the implantation process has been initiated hormones playa largely permissive role.There is considerable species variation in the reaction of the uterus in preparation for and during implantation. De Feo (1967) reviewed this subject very thoroughly in the first edition of this book. The great majority of research investigations have been carried out on laboratory rodents, with very little on primates or the larger domestic animals. It follows therefore that any general account of implantation will lean heavily on information acquired from laboratory animals. Although one would like to have a much more general coverage, one cannot escape the reality that information acquired from many experiments on large numbers of laboratory animals provides a sound foundation on which to build. Information from primates or wild mammals will always tend to be fragmentary because of the difficulty of obtaining large numbers of specimens. Anyone who has worked with rats or mice knows how easy it is to be misled by the results from two or three animals. The only sensible course therefore is to get as

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“…Endometrial histology directly correlates with changes in the ovarian-derived steroid hormones estradiol and progesterone [23]. Microarray data obtained from human uteri during a normal menstrual/hormonal cycle suggest that expression of the TRO gene is hormone-dependent [24,25].…”

Section: Discussionmentioning

confidence: 99%

Induction of trophinin in human endometrial surface epithelia by CGβ and IL‐1β

et al. 2007

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During embryo implantation, trophinin mediates cell adhesion by homophilic binding at the apical surfaces of trophectoderm and endometrium. Trophinin is expressed on the human endometrial epithelia in rare occasions. We developed hCGcoated agarose beads that mimic the physical and physiological features of an implantation-stage human blastocyst. When hCG-coated beads were applied to human endometrial epithelial cells in the presence of IL-1b, endometrial cells acquired strong trophinin expression and the ability for apical cell adhesion with trophinin-expressing human trophoblastic cells. These results provide a mechanism for trophinin-mediated adhesion of human blastocyst to endometrium by a spatially and temporally restricted paracrine effect of hCG derived from the blastocyst.

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Estrogen-Progesterone Relationships in the Development of Secretory Endometrium

Cited by 55 publications

References 11 publications

Effect of steroid hormones on tissue remodelling and progesterone receptors in the uterus of seasonally anoestrous brushtail possums (Trichosurus vulpecula)

Effect of steroid hormones on tissue remodelling and progesterone receptors in the uterus of seasonally anoestrous brushtail possums (Trichosurus vulpecula)

The Implantation Reaction

Induction of trophinin in human endometrial surface epithelia by CGβ and IL‐1β

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