1991
DOI: 10.1016/0378-5122(91)90296-3
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Estrogen modulates responses of atherosclerotic coronary arteries

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Cited by 44 publications
(55 citation statements)
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“…Volterrani et al have shown that estradiol 17h reduces peripheral vascular resistances and increases peripheral blood flow in menopausal women [24]. Williams et al have reported a reversal of the acetylcholineinduced vasoconstriction by estradiol 17h implants in ovariectomised monkeys fed with an atherogenic diet for 30 months [12]. Collins et al have shown that acute administration of estradiol 17h reverses the coronary constrictor effect of acetylcholine in menopausal women with coronary artery disease and that is gender dependent [21].…”
Section: Discussionmentioning
confidence: 99%
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“…Volterrani et al have shown that estradiol 17h reduces peripheral vascular resistances and increases peripheral blood flow in menopausal women [24]. Williams et al have reported a reversal of the acetylcholineinduced vasoconstriction by estradiol 17h implants in ovariectomised monkeys fed with an atherogenic diet for 30 months [12]. Collins et al have shown that acute administration of estradiol 17h reverses the coronary constrictor effect of acetylcholine in menopausal women with coronary artery disease and that is gender dependent [21].…”
Section: Discussionmentioning
confidence: 99%
“…In vitro studies have shown that estradiol 17h has a relaxing effect upon precontracted rabbit and human coronary artery rings [14][15][16] and that estradiol 17h reveals calcium antagonistic properties [17,18]. In vivo studies have demonstrated that estrogens potentiate the endotheliumdependent vasodilator response to acetylcholine in animals [12] and in humans [19 -21]. Clinical studies have shown that acute administration of sublingual estradiol 17h improves exercise-induced myocardial ischemia in menopausal patients with coronary arteries [22] and reduces peripheral vascular resistances [23,24].…”
Section: Introductionmentioning
confidence: 99%
“…Protective effects of estrogen for women may be related to the gender effect. Previous study using estrogen-deficient monkeys showed that estrogen replacement therapy improved the response to acetylcholine in coronary arteries [22]. Also, habitual smoking [23] and drinking [24] are well-recognized predictors of coronary spasms.…”
Section: Potential Of Mda-ldl As a Predictor Of Coronary Spasmmentioning
confidence: 99%
“…Estrogens are known to protect the vessel wall both indirectly, by improving metabolic profile [6] and by a direct beneficial action on endothelial cells as demonstrated by the negative effects of acute endogenous estrogen deprivation following ovariectomy [18,55]. The progressive estrogen levels decrease, as occurring in menopausal women which is characterized by endothelial dysfunction, both in normotensive and hypertensive females [8,38].…”
Section: Cox-derived Edcfs In Other Clinical Conditionsmentioning
confidence: 99%