Estrogen modulates in vitro T cell responses in a concentration- and receptor-dependent manner: Effects on intracellular molecular targets and antioxidant enzymes

Priyanka, Hannah P.; Krishnan, Harini C.; Singh, Ran Vijay; Hima, Lalgi; ThyagaRajan, Srinivasan

doi:10.1016/j.molimm.2013.05.226

Cited by 68 publications

(60 citation statements)

References 50 publications

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“…IFN-γ levels and its mRNA expression were found to be augmented in mouse splenocytes with estrogen stimulation [41]. Similar alterations were found in splenic lymphocytes where estrogen differentially altered lymphoproliferation and cytokine production influenced by estrogen receptors in vitro and in vivo [3,28,42].…”

Section: Discussionsupporting

confidence: 60%

“…The role of estrogen as an immune modulator in inflammatory conditions depends on the type of immune stimuli, the target organs, expression of its receptor subtypes, dose and timing of administration [2]. It may also be related to the ability of estrogen to alter Th1 and Th2 immunity depending on the dose administered, modulate estrogen receptor (ER)-dependent T cell responses that are mediated through antioxidant enzymes and nitric oxide, and cause damage to hypothalamic dopaminergic activity and peripheral sympathetic noradrenergic (NA) neuronal activity in the secondary lymphoid organs such as spleen and lymph nodes [3][4][5]. The regular fluctuations observed in circulating levels of estrogen during the estrous cycle influence the proliferation of T and B cell populations and alter the localization of IgA-producing plasma cells [6].…”

Section: Introductionmentioning

confidence: 99%

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Estrogen upregulates inflammatory signals through NF-κB, IFN-γ, and nitric oxide via Akt/mTOR pathway in the lymph node lymphocytes of middle-aged female rats

Pratap

Sharma

Mohanty

et al. 2015

International Immunopharmacology

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Section: Discussionsupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Estrogen upregulates inflammatory signals through NF-κB, IFN-γ, and nitric oxide via Akt/mTOR pathway in the lymph node lymphocytes of middle-aged female rats

Pratap

Sharma

Mohanty

et al. 2015

International Immunopharmacology

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“…We suppose that the hormonal status during pregnancy may improve the course of the disease. Namely, it has recently been shown in an in vitro study that the effects of estrogen on the cell-mediated immune response are dependent on its concentrations and mediated through specific estrogen receptors involving intracellular signaling pathways and anti-oxidant enzymes [38].…”

Section: Discussionmentioning

confidence: 99%

Human papilloma virus vaccination in patients with an aggressive course of recurrent respiratory papillomatosis

Boltežar

Matičič

Šereg-Bahar

et al. 2014

Eur Arch Otorhinolaryngol

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In the case of an aggressive course of recurrent respiratory papillomatosis (RRP), adjuvant therapy can be used besides surgery. The aim of the study was to investigate the influence of vaccination with a quadrivalent vaccine against human papilloma viruses (HPV) types 6, 11, 16 and 18 on the course of RRP. Eleven subjects aged 13-46 years with a rapid growth of laryngeal papillomas were included in the study. They were vaccinated with three doses of the quadrivalent prophylactic HPV vaccine (Silgard(®), MSD) and followed up for 12-52 months. The intervals between the successive surgical procedures, the extension of the disease (Derkay score) at each surgery, and the number of surgical procedures per year before vaccination and after its completion were compared. The mean interval between the surgical procedures was 271.2 days before the vaccination and 537.4 days after it (p = 0.034). The mean number of surgeries per year was 2.16 before the vaccination and 0.93 after it (p = 0.022). The Derkay score did not change significantly after vaccination. Complete remission of the disease was observed in one patient, partial response to the vaccination was observed in seven patients and no response was observed in three patients. In conclusion, vaccination with the quadrivalent HPV vaccine can favorably influence the course of RRP in patients with the rapid growth of the papillomas. It significantly prolongs the intervals between the surgical procedures and reduces the number of procedures needed in the majority of patients. The present investigation can serve as a pilot study for further research. For a final conclusion a longer follow-up and studies on more patients are necessary.

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“…There has been no study so far to explore the effect of E2 on Th17 during pregnancy. Concerning the molecular mechanisms implicated in the immunomodulatory roles of E2, a recent article has shown that those E2 effects are mediated through its receptors and involve intracellular signaling pathways like ERK, CREB, and Akt, as well as antioxidant enzymes (103). …”

Section: Immunomodulatory Properties Of Pregnancy Hormonesmentioning

confidence: 99%

The Endocrine Milieu and CD4 T-Lymphocyte Polarization during Pregnancy

et al. 2014

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Acceptance of the fetal semi-allograft by the mother’s immune system has become the focus of intensive research. CD4+ T cells are important actors in the establishment of pregnancy. Th1/Th2 paradigm has been expanded to include CD4+ regulatory T (Treg) and T helper 17 (Th17) cells. Pregnancy hormones exert very significant modulatory properties on the maternal immune system. In this review, we describe mechanisms by which the endocrine milieu modulates CD4 T cell polarization during pregnancy. We first focused on Treg and Th17 cells and on their importance for pregnancy. Secondly, we review the effects of pregnancy hormones [progesterone (P4) and estradiol (E2)] on immune cells previously described, with a particular attention to human chorionic gonadotropin (hCG). The importance of Treg cells for pregnancy is evidenced. They are recruited before implantation and are essential for pregnancy maintenance. Decreased number or less efficient Treg cells are implicated in fertility disorders. As for Th17 cells, the few available studies suggest that they have a negative impact on fertility. Th17 frequency is increased in infertile patients. With the combination of its pro-effects on Th2 and Treg cells and anti-effects on Th1 and Th17 cells, P4 contributes to establishment of a favorable environment for pregnancy. E2 effects are more dependent on the context but it seems that E2 promotes Treg and Th2 cells while it inhibits Th1 cells. hCG positively influences activities of Treg and uterine natural killer cells. This embryo signal is an essential actor for the success of pregnancy, both as the endocrine factor regulating P4 secretion by the ovarian corpus luteum, but also as a paracrine agent during implantation as well as an angiogenic and immunologic mediator during the course of gestation. Luteinizing hormone (LH) immune properties begin to be studied but its positive impact on Treg cells suggests that LH could be a considerable immunomodulator in the mouse.

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Estrogen modulates in vitro T cell responses in a concentration- and receptor-dependent manner: Effects on intracellular molecular targets and antioxidant enzymes

Cited by 68 publications

References 50 publications

Estrogen upregulates inflammatory signals through NF-κB, IFN-γ, and nitric oxide via Akt/mTOR pathway in the lymph node lymphocytes of middle-aged female rats

Estrogen upregulates inflammatory signals through NF-κB, IFN-γ, and nitric oxide via Akt/mTOR pathway in the lymph node lymphocytes of middle-aged female rats

Human papilloma virus vaccination in patients with an aggressive course of recurrent respiratory papillomatosis

The Endocrine Milieu and CD4 T-Lymphocyte Polarization during Pregnancy

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