Estrogen modulates abdominal adiposity and protects female mice from obesity and impaired glucose tolerance

Stubbins, Renee; Holcomb, Valerie B.; Hong, June Seok; Núñez, Nomelí P.

doi:10.1007/s00394-011-0266-4

Cited by 274 publications

(259 citation statements)

References 38 publications

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“…For example, studies in mice have found that estrogen may have a protective effect for females, possibly through its inhibitory effect of key adipogenic genes. 50 Alternatively, there could be gender differences in the way BPA alters eating patterns, as studies have found that male, but not female, rats exposed perinatally to BPA developed a preference for a sweet taste. 51 Strengths of our study include using a large, nationally representative and diverse sample of US children and our ability to adjust for a number of covariates, including demographics, urinary creatinine, serum cotinine, and soda consumption.…”

Section: Discussionmentioning

confidence: 99%

Bisphenol A and Chronic Disease Risk Factors in US Children

Eng¹,

Lee²,

Gebremariam³

et al. 2013

Pediatrics

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WHAT'S KNOWN ON THIS SUBJECT: Bisphenol A (BPA) is a known endocrine disruptor found in many products with which children come into contact. Although BPA in adults is associated with obesity, diabetes, and cardiovascular disease, little is known about its effects in children. WHAT THIS STUDY ADDS:This study found that higher BPA levels are associated with obesity and abnormal waist circumferenceto-height ratio in children. abstract OBJECTIVE: To evaluate the relationship between urinary bisphenol A (BPA) levels and measures of adiposity and chronic disease risk factors for a nationally representative US pediatric sample. METHODS:We used the NHANES 2003-2010 to evaluate cross-sectional associations between urinary BPA and multiple measures of adiposity, cholesterol, insulin, and glucose for children aged 6 to 18 years, adjusting for relevant covariates (eg, demographics, urine creatinine, tobacco exposure, and soda consumption). RESULTS:We found a higher odds of obesity (BMI $95th percentile) with increasing quartiles of BPA for quartiles 2 vs 1 (odds ratio [OR] 1.74, 95% confidence interval [CI] 1.17-2.60, P = .008), 3 vs 1 (OR 1.64, 95% CI 1.09-2.47, P = .02), and 4 vs 1 (OR 2.01, 95% CI 1.36-2.98, P = .001). We also found a higher odds of having an abnormal waist circumference-to-height ratio (quartiles 2 vs 1 [OR 1.37, 95% CI 0.98-1.93, P = .07], 3 vs 1 [OR 1.41, 95% CI 1.07-1.87, P = .02], and 4 vs 1 [OR 1.55, 95% CI 1.12-2.15, P = .01]). We did not find significant associations of BPA with any other chronic disease risk factors.CONCLUSIONS: Higher levels of urinary BPA were associated with a higher odds of obesity (BMI .95%) and abnormal waist circumference-to-height ratio. Longitudinal analyses are needed to elucidate temporal relationships between BPA exposure and the development of obesity and chronic disease risk factors in children. Pediatrics 2013;132:e637-e645 AUTHORS:

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Section: Discussionmentioning

confidence: 99%

Bisphenol A and Chronic Disease Risk Factors in US Children

Eng¹,

Lee²,

Gebremariam³

et al. 2013

Pediatrics

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“…This phenomenon has also been demonstrated in female rodents (Tarttelin & Gorski 1971, Asarian & Geary 2013, sustaining the association between estradiol concentrations and food intake. Moreover, in response to HFD consumption, female rats gain less weight than males, but this differential response is no longer observed after ovariectomy (Stubbins et al 2012), which is similar to the tendency for postmenopausal women to increase their body weight as their estrogen levels decrease (Brown et al 2010, Hamilton et al 2016. In fact, females are reported to be more resistant to obesity than males in part due to the higher expression of ERα in astrocytes (Morselli et al 2015).…”

Section: Differences Between Males and Females In The Astrocytic Respmentioning

confidence: 80%

“…Estrogens are protective against weight gain, adiposity and obesityassociated complications (Stubbins et al 2012, Dakin et al 2015. These effects are mediated through estrogen receptor alpha (ERα), as activation of this receptor regulates food intake, glucose homeostasis and energy R63 Review p argente-arizón and others Glial cells and energy balance expenditure (Musatov et al 2007, Xu et al 2011, with activation of ERs in the hypothalamic ventromedial nucleus specifically augmenting energy expenditure (Gambacciani et al 1997, Musatov et al 2007, Xu et al 2011.…”

Section: Differences Between Males and Females In The Astrocytic Respmentioning

confidence: 99%

Glial cells and energy balance

Argente-Arizón

Guerra-Cantera

Garcia-Segura

et al. 2017

Journal of Molecular Endocrinology

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The search for new strategies and drugs to abate the current obesity epidemic has led to the intensification of research aimed at understanding the neuroendocrine control of appetite and energy expenditure. This intensified investigation of metabolic control has also included the study of how glial cells participate in this process. Glia, the most abundant cell type in the central nervous system, perform a wide spectrum of functions and are vital for the correct functioning of neurons and neuronal circuits. Current evidence indicates that hypothalamic glia, in particular astrocytes, tanycytes and microglia, are involved in both physiological and pathophysiological mechanisms of appetite and metabolic control, at least in part by regulating the signals reaching metabolic neuronal circuits. Glia transport nutrients, hormones and neurotransmitters; they secrete growth factors, hormones, cytokines and gliotransmitters and are a source of neuroprogenitor cells. These functions are regulated, as glia also respond to numerous hormones and nutrients, with the lack of specific hormonal signaling in hypothalamic astrocytes disrupting metabolic homeostasis. Here, we review some of the more recent advances in the role of glial cells in metabolic control, with a special emphasis on the differences between glial cell responses in males and females.

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“…The age-related hormonal alteration, i.e. estrogen level pre-and post-menopause [63], also has a large impact on metabolic health, and therefore investigating the diet-induced phenotypic plasticity on female mice would require a separate study dedicated for this purpose.…”

Section: Liver Plasticity Induced By the Diet Switchesmentioning

confidence: 99%

“…Previous mice studies on NAFLD development typically apply a high percentage of fat (45-60E%) to resemble the Western-style diet [63]. However, NAFLD is acutely induced at young age and this does not represent the development in human populations, which accumulate the adverse effect of a Western-style diet over many years.…”

Section: Introductionmentioning

confidence: 99%

Diet-induced phenotypic plasticity during aging

Rusli

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Estrogen modulates abdominal adiposity and protects female mice from obesity and impaired glucose tolerance

Abstract: Estrogen protects female mice from obesity and impaired glucose tolerance possibly by modulating the expression of genes regulating adipogenesis, lipogenesis, and lipolysis.

Cited by 274 publications

References 38 publications

Bisphenol A and Chronic Disease Risk Factors in US Children

Bisphenol A and Chronic Disease Risk Factors in US Children

Glial cells and energy balance

Diet-induced phenotypic plasticity during aging

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