1979
DOI: 10.1016/0039-128x(79)90049-7
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Estrogen metabolism in neural tissues of rabbits: 17β — Hydroxysteroid oxidoreductase activity

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Cited by 16 publications
(7 citation statements)
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“…Oestradiol 17^-oxidoreductase in neural tissues of rats The present data demonstrating a system, which interconverts oestradiol and oestrone, expands our earlier observations in rabbits (Reddy et al 1974b;Reddy 1979). The tissues from females showed higher activity of oestradiol 17ß-oxidoreductase than males (Table 4).…”
Section: Catecholoestrogenformation In Neural Tissues Of Ratssupporting
confidence: 88%
See 1 more Smart Citation
“…Oestradiol 17^-oxidoreductase in neural tissues of rats The present data demonstrating a system, which interconverts oestradiol and oestrone, expands our earlier observations in rabbits (Reddy et al 1974b;Reddy 1979). The tissues from females showed higher activity of oestradiol 17ß-oxidoreductase than males (Table 4).…”
Section: Catecholoestrogenformation In Neural Tissues Of Ratssupporting
confidence: 88%
“…The higher oestradiol 17ß-oxidoreductase activity in pituitary and hypothala¬ mus may suggest its importance in the regulation of endogenous levels of oestradiol in these tissues and control of neuroendocrine function. We have observed that the reaction catalyzed by the oestra¬ diol 17ß-oxidoreductase in neural tissues of rats favours the reduction of oestrone which is similar to rabbit neural tissues (Reddy 1979). The low levels of oestrone reduction in hypo¬ thalamus may in part be due to the hypothalamic neurons that are specific to oestrone (Luttge & Whalen 1970).…”
Section: Catecholoestrogenformation In Neural Tissues Of Ratsmentioning
confidence: 95%
“…In super natants from brain samples, 27% of the extractable radioac tivity was ['H]estrone while in supernatants from pituitary gland and peripheral tissues it accounted for only 16%. The activity of l7|3-hydroxysteroid oxidoreductase is consider ably higher in the pituitary gland than in the brain of rhesus monkeys [27], and our results might be explained by the fact that the equilibrium of the estradiol-estrone interconver sion catalyzed by this enzyme lies towards estradiol [23]. There is strong evidence in the male rat that estrogenic metabolites of testosterone produced by intracerebral aromatization mediate the effects of testosterone both on sexual differentiation of the brain during development [16] and on activation of sexual behavior in the adult [4,6,12].…”
Section: Discussionmentioning
confidence: 59%
“…the interconversion of oestrone and oestradiol has been demonstrated in a large number of mouse tissues (Milewich, Garcia & Gerrity, 1985), tissues of other animals (Bitar, Cochran & Warren, 1979;Reddy, 1979;Entenmann, Sierralta & Jungblut, 1980;Hartiala, Uotila & Nienstedt, 1980), and in vari¬ ous human tissues, e.g. endometrium (Tseng, Stolee & Gurpide, 1972), vaginal mucosa (Weinstein, Frost & Hsia, 1968), lung (Milewich, Hendricks & Romero, 1982), testis (Ryan & Engel, 1953), ileum (Ryan & Engel, 1953), skin (Weinstein et al 1968), liver (Breuer, Knuppen & Haupt, 1966), adipose tissue (Bleau, Roberts &Chapdelaine, 1974) and erythrocytes (Jacobsohn & Hochberg, 1968).…”
mentioning
confidence: 96%