Estrogen is a modulator of vascular inflammation

Chakrabarti, Subhadeep; Lekontseva, Olga; Davidge, Sandra T.

doi:10.1002/iub.48

Cited by 92 publications

(66 citation statements)

References 53 publications

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“…6 In animal models, oestrogen deficiency has been reported to lead to an increased level of tumour necrosis factor-alpha (TNF-a) and endothelin-1, leading to a possible proinflammatory state in the vasculature. 7 It is possible that the changes in oestrogen levels in our patient taking an AI led to changes in vasculature permeability and optic nerve swelling. Early recognition of this possible side effect may be crucial, as prompt discontinuation of the drug was associated with improvement of symptoms.…”

Section: Discussionmentioning

confidence: 93%

Bilateral Optic Disc Swelling Following Anastrozole Therapy

Coppes¹,

Lukas²,

Fleming

et al. 2014

Neuro-Ophthalmology

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A 56-year-old female with early-stage breast cancer, stage IA grade 1 endometrial cancer, and stage IC grade 1 ovarian cancer developed sudden-onset visual changes and right inferior visual field defect following anastrozole therapy. Examination revealed severe bilateral optic disc swelling and impaired visual acuity. Laboratory work-up was otherwise unremarkable. Anastrozole was discontinued and over the next month, patient had near-complete resolution of swelling in the right eye and improvement in the left eye. This is the only reported case of optic disc swelling following anastrozole therapy.

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Section: Discussionmentioning

confidence: 93%

Bilateral Optic Disc Swelling Following Anastrozole Therapy

Coppes¹,

Lukas²,

Fleming

et al. 2014

Neuro-Ophthalmology

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“…TNF-␣'s proinflammatory effects include upregulation of the adhesion molecules ICAM-1, VCAM-1, and E-selectin in endothelial cells, enhancing the recruitment of leukocytes (11,25,45). TNF-␣ also increases oxidative stress by activation of NADPH oxidase (9). iNOS, another proinflammatory gene, was increased markedly at the protein level only in the Late group.…”

Section: Discussionmentioning

confidence: 99%

Impact of aging vs. estrogen loss on cardiac gene expression: estrogen replacement and inflammation

Pechenino

Lin

Mbai

et al. 2011

Physiological Genomics

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“…These include modulation of vascular tone via both the endothelium-dependent mechanisms, as well as the mechanisms inherent to the VSMC (81). In addition, antioxidant, anti-inflammatory, and antiproliferative pathways modulated by estrogen protect against vessel injury from exposure to the vascular risk factors (16). This has been a subject of recent reviews (as indicated above), and will not be covered in detail here.…”

Section: Vascular Changes In Aging Womenmentioning

confidence: 99%

Endothelin in the female vasculature: a role in aging?

Lekontseva

Chakrabarti

Davidge

2010

American Journal of Physiology-Regulatory, Integrative and Comp

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vascular diseases are the leading cause of morbidity and mortality in the world. Aging is associated with an increased incidence of cardiovascular disease. Premenopausal women are relatively protected from vascular alterations compared with age-matched men, likely due to higher levels of the female sex hormones. However, these vasoprotective effects in women are attenuated after menopause. Thus, the vascular system in aging women is affected by both the aging process as well as loss of hormonal protection, positioning women of this age group at a high risk for cardiovascular diseases such as hypertension, myocardial infarction, and stroke. The endothelin system in general and endothelin-1 (ET-1) in particular plays an important role in the pathogenesis of vascular dysfunction associated with aging. Evidence suggests that the female sex steroids can interfere with the vascular expression and actions of ET-1 via several mechanisms, which may further contribute to pathological processes in the vasculature of aging women. In this review, we have summarized hormone-dependent vascular pathways whereby ET-1 may mediate the deleterious effects of aging in postmenopausal females.ET-1; menopause; estrogen; vasoconstriction; inflammation AGING OF THE VASCULAR SYSTEM is a complex process characterized by sustained proinflammatory and proconstrictor changes in the vascular microenvironment. The resulting structural and functional alterations in systemic vasculature lead to increased risk of cardiovascular diseases such as hypertension, myocardial infarction, and stroke in the aging population (12,18,51,70). In the absence of chronic preexisting conditions, such as diabetes, premenopausal women express a favorable cardiovascular phenotype compared with age-matched men, largely due to the vasoprotective role of ovarian steroids such as estrogen (92). An alteration in circulating sex hormones at menopause, such as the decrease in estrogens and a relative excess of androgens, is associated with the conversion from a low-to high-risk cardiovascular profile (19,56). Although the mechanisms underlying the pathogenesis of vascular dysfunction in postmenopausal women are not completely understood, it is believed to result from a complex interplay between the aging process and the decline in ovarian hormones like estrogen.Endothelin has emerged as one of the key mediators of vascular dysfunction and remodeling in aging. Interestingly, there is evidence that female sex steroids (in particular, estrogen) can regulate the endothelin system at various levels from gene transcription and posttranslational modification of the peptide to expression of its vascular receptors and postreceptor signaling events. This review will summarize current knowledge on the impact of aging and female sex hormones on the endothelin system, as well as outline directions where further research is needed. A better understanding of the role of endothelin in the pathogenesis of vascular dysfunction in postmenopausal women may lead to the development of novel sex-...

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Estrogen is a modulator of vascular inflammation

Cited by 92 publications

References 53 publications

Bilateral Optic Disc Swelling Following Anastrozole Therapy

Bilateral Optic Disc Swelling Following Anastrozole Therapy

Impact of aging vs. estrogen loss on cardiac gene expression: estrogen replacement and inflammation

Endothelin in the female vasculature: a role in aging?

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