Estrogen influences stimulated water intake by ovariectomized female rats

Krause, Eric G.; Curtis, Kathleen S.; Davis, Linda M.; Stowe, Jennifer R.; Contreras, Robert J.

doi:10.1016/s0031-9384(03)00095-7

Cited by 67 publications

(82 citation statements)

References 24 publications

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“…Indeed, ovariectomy abolished fluctuations in water consumption [56]. Thus, estrogen should be an important faster factor in modifying spontaneous water consumption [57]. Moreover, there was evidence that estrogen also should influence stimulated water intake.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, female rats have been shown to consume more water than do male rats after water deprivation [58]. Sex difference in deprivation-induced water consumption suggested hormonal mediation [57]. According to these authors, there were two different mechanisms that underlie stimulated water intake: intracellular dehydration associated with increased plasma sodium concentration, and extracellular dehydration related to a sudden decrease in blood pressure.…”

Section: Discussionmentioning

confidence: 99%

“…According to these authors, there were two different mechanisms that underlie stimulated water intake: intracellular dehydration associated with increased plasma sodium concentration, and extracellular dehydration related to a sudden decrease in blood pressure. It was possible that estrogen may influence water intake trough its action on one or both pathways [57].…”

Section: Discussionmentioning

confidence: 99%

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Effects of Ovariectomy and 17<i>β</i>-Estradiol Replacement on Dopamine D2 Receptors in Female Rats: Consequences on Sucrose, Alcohol, Water Intakes and Body Weight

Bâ¹,

Silué²,

Bamba³

et al. 2018

JBBS

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Background: Mechanisms underlying overeating-induced obesity in postmenopausal woman include functional lack of 17β-estradiol dysregulating dopamine D2 receptors, thereby inducing food addiction, glucose craving or alcohol dependence through reward circuitry. This study aimed at further understanding 17β-estradiol and dopamine D2 receptors interferences in the etiology of woman obesity. Method: Seventy-two Wistar female rats weighing 200 -205 g, individually-housed, were divided into non-ovariectomized control (C = 6 groups) and ovariectomized rats (OVX = 6 groups) which were concurrently subjected to the following treatments: Non-drug-treated (DMSO vehicle), 17β-estradiol (E2, 5 µg/kg, s.c.), sulpiride (SUL, 20 mg/kg, i.p.), bromocriptine (BR, 0.1 mg/kg, i.p.), E2 + SUL or E2 + BR, designating the 6 constitutive groups of either control or ovariectomy. Within each experimental group, consumption of different solutions (10% alcohol, 10% sucrose and water) as well as food intake and body weight were daily measured, for 10 consecutive days. Results: This study indicated that D2S was a specific inducer of alcohol and food intakes, but reduced sugar consumption. In addition, 17β-estradiol regulated the body weight set point, modulating D2S functions towards increased food intake at lower weights and decreased food intake at higher weights. D2S met the slow genomic actions induced by 17β-estradiol. Conversely, D2L inhibited alcohol and food intakes, but induced specifically sugar consumption, thereby regulating blood glucose levels and promoting energy expenditure in reducing body weight. Indeed, 17β-estradiol exerted a tonic inhibition on D2L which was released by OVX, exacerbating sugar intake and increasing body weight. D2L mediated the rapid metabolic effects of that activation of the mostly expressed presynaptically D2S-class autoreceptors decreased dopamine release stimulating food intake, whereas activation of the predominantly postsynaptic isoform D2L receptors increased dopamine activity inhibiting food intake. Our studies indicated that 17β-estradiol acted on the two types of D2 receptors showing opposite functions to equilibrate energy intake vs. expenditure for weight set point regulation. Our data also supported biochemical findings reporting that 17β-estradiol induced D2 genes transcriptional regulation, thereby involving both types of D2 receptors in the etiology of obesity. The combined dysregulated effects of D2L and D2S receptors, as 17β-estradiol was lacking, would be causal factors underlying the etiology of obesity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effects of Ovariectomy and 17<i>β</i>-Estradiol Replacement on Dopamine D2 Receptors in Female Rats: Consequences on Sucrose, Alcohol, Water Intakes and Body Weight

Bâ¹,

Silué²,

Bamba³

et al. 2018

JBBS

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“…In contrast, neither the smaller peak in plasma progestin levels during diestrus 2 nor the larger periovulatory peak is related to changed eating. The estrous inhibition of eating in rats is not secondary: 1) to stimulation of locomotor activity because the former is expressed as a decrease in meal size and the latter causes a decrease in meal frequency (207); 2) to increases in appetitive or consummatory reproductive behavior because both estradiol and progesterone are necessary to normalize most or all reproductive behaviors in ovariectomized rats (242,549,690); or 3) to estrogen-dependent changes in water intake (151,224,237,355,384,406,726,727) because these are not synchronous in intact, cycling rats (maximum water intake occurs on diestrus 1 and decreases on diestrus 2) and because food intake increased ϳ3 days before water intake increased after ovariectomy (727) [the estrogenic controls of eating and drinking also were dissociated in several tests in guinea pigs (155)]. Nevertheless, it would be useful to determine spontaneous meal patterns in a more naturalistic environment permitting social interactions, reproductive behavior, foraging for food, etc.…”

Section: Sex Differences In Eating In Rats and Micementioning

confidence: 99%

Sex differences in the physiology of eating

Asarian

Geary²

2013

American Journal of Physiology-Regulatory, Integrative and Comp

392

349

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(HPG) axis function fundamentally affects the physiology of eating. We review sex differences in the physiological and pathophysiological controls of amounts eaten in rats, mice, monkeys, and humans. These controls result from interactions among genetic effects, organizational effects of reproductive hormones (i.e., permanent early developmental effects), and activational effects of these hormones (i.e., effects dependent on hormone levels). Male-female sex differences in the physiology of eating involve both organizational and activational effects of androgens and estrogens. An activational effect of estrogens decreases eating 1) during the periovulatory period of the ovarian cycle in rats, mice, monkeys, and women and 2) tonically between puberty and reproductive senescence or ovariectomy in rats and monkeys, sometimes in mice, and possibly in women. Estrogens acting on estrogen receptor-␣ (ER␣) in the caudal medial nucleus of the solitary tract appear to mediate these effects in rats. Androgens, prolactin, and other reproductive hormones also affect eating in rats. Sex differences in eating are mediated by alterations in orosensory capacity and hedonics, gastric mechanoreception, ghrelin, CCK, glucagon-like peptide-1 (GLP-1), glucagon, insulin, amylin, apolipoprotein A-IV, fatty-acid oxidation, and leptin. The control of eating by central neurochemical signaling via serotonin, MSH, neuropeptide Y, Agouti-related peptide (AgRP), melanin-concentrating hormone, and dopamine is modulated by HPG function. Finally, sex differences in the physiology of eating may contribute to human obesity, anorexia nervosa, and binge eating. The variety and physiological importance of what has been learned so far warrant intensifying basic, translational, and clinical research on sex differences in eating.neuroendocrinology; estrogens; testosterone; eating disorders; obesity SEX DIFFERENCES ARE PERVASIVE in physiology and medicine (51,64,73,109,110,466,797,826). The controls of eating and energy homeostasis are no exceptions. It was observed approximately 100 years ago that removal of the ovaries leads to marked accretion of adipose tissue in rats (697), that daily food intake expressed as kilocalories per gram body weight differs between male and female rats (778), and that food intake varies regularly through the ovarian cycle in intact female rats (674, 779). Sex differences in eating have been the subject of physiological research ever since. The clinical relevance of this work is increasingly evident. In the United States, women are approximately threefold more vulnerable than men to psychiatric eating disorders (346,351) and approximately twofold more vulnerable to severe and morbid obesity (BMI Ն 35 and 40 kg/m 2 , respectively, mass/height 2 ) (226). Women also appear to suffer more from these disorders in terms of physical and psychological functioning and quality of life (24,84,273,292,465,531,762). The increased obesity burden suffered by women is reflected in the fact that Ͼ80% of bariatric surgery patients in the U...

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“…Ovariectomy in rats resulted in increased water intake [48]. E 2 administration decreased the water intake in female rats after water deprivation [49]. E 2 administration prolonged the onset of drinking behavior in female rats administrated with NaCl solution [50].…”

Section: Discussionmentioning

confidence: 99%

Effect of Systemic Estradiol Administration on Circadian Body Temperature and Activity Rhythms in Female Rats

Uchida¹,

Marui²,

Tokizawa³

et al. 2017

Anat Physiol

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The estrus cycle affects the circadian body temperature (T b ) and activity rhythms, and progesterone is related to these alterations. However, it is not clear whether estrogen (E 2 ) influences it. The present study examined whether E 2 affects the circadian T b and activity rhythm. Ovariectomized rats were implanted with a silastic plate with or without E 2 underneath the dorsal skin (E 2 (-) and E 2 (+)), and these along with sham operated rats (SH) were measured for T b and activity for 2 weeks. The mean T b was lower, and mean activity was higher in E 2 (+) than that in E 2 (-) in the day. In the dark phase, the slope of the relationship between the mean T b and activity in E 2 (-) was the greatest. The slope in E 2 (+) and SH was greater in the light phase than that in the dark phase. The daily peak of T b and activity was lower in E 2 (+) than that in E 2 (-). The appearance of the nadir in T b was later in E 2 (+) and SH than that in E 2 (-). The appearance of the peak in T b and activity was earlier in E 2 (+) and SH than that in E 2 (-). Thus, E 2 may modulate the circadian T b and activity rhythm in female rats.

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Estrogen influences stimulated water intake by ovariectomized female rats

Cited by 67 publications

References 24 publications

Effects of Ovariectomy and 17<i>β</i>-Estradiol Replacement on Dopamine D2 Receptors in Female Rats: Consequences on Sucrose, Alcohol, Water Intakes and Body Weight

Effects of Ovariectomy and 17<i>β</i>-Estradiol Replacement on Dopamine D2 Receptors in Female Rats: Consequences on Sucrose, Alcohol, Water Intakes and Body Weight

Sex differences in the physiology of eating

Effect of Systemic Estradiol Administration on Circadian Body Temperature and Activity Rhythms in Female Rats

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Estrogen influences stimulated water intake by ovariectomized female rats

Cited by 67 publications

References 24 publications

Effects of Ovariectomy and 17&lt;i&gt;β&lt;/i&gt;-Estradiol Replacement on Dopamine D2 Receptors in Female Rats: Consequences on Sucrose, Alcohol, Water Intakes and Body Weight

Effects of Ovariectomy and 17&lt;i&gt;β&lt;/i&gt;-Estradiol Replacement on Dopamine D2 Receptors in Female Rats: Consequences on Sucrose, Alcohol, Water Intakes and Body Weight

Sex differences in the physiology of eating

Effect of Systemic Estradiol Administration on Circadian Body Temperature and Activity Rhythms in Female Rats

Contact Info

Product

Resources

About

Effects of Ovariectomy and 17<i>β</i>-Estradiol Replacement on Dopamine D2 Receptors in Female Rats: Consequences on Sucrose, Alcohol, Water Intakes and Body Weight

Effects of Ovariectomy and 17<i>β</i>-Estradiol Replacement on Dopamine D2 Receptors in Female Rats: Consequences on Sucrose, Alcohol, Water Intakes and Body Weight