Estrogen Influences on Cognition

Gasbarri, Antonella; Tomaz, Carlos

doi:10.5772/26460

Cited by 2 publications

(3 citation statements)

References 157 publications

(154 reference statements)

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“…From a neurophysiological point of view, in fact, the learning process is essentially functional, ie entrusted to reverberant circuits and unstable morphological modifications, while the memory process is structural and presupposes stable morphological modifications. These changes are accompanied by an increase in protein synthesis and consist of an increase in the number and volume of the dendritic spines [2].…”

Section: Luis Bunuelmentioning

confidence: 99%

“…The latter's hypotheses stimulated the development of computer models of neural networks; his assumptions contributed to the study of memory, demonstrating that this information is not preserved in hippocampal structures and related diencephalic structures and that the cerebral cortex can be the main location for long-term storage of the different aspects of memory. Since different cortical areas preside over different cognitive functions, it is not surprising that information relating to the specific cognitive function of the corresponding cortical area is stored in these regions [2].…”

Section: Anatomical Structuresmentioning

confidence: 99%

“…Recent neuroimaging studies also suggest that a combination of omega-3fatty acids, aerobic exercise and cognitive stimulation prevents a decline in the gray matter volume of the frontal, parietal and cingulated cortex in patients with mild cognitive impairment. Particularly interesting are those studies suggesting that physical activity, a balanced diet, cognitive stimulation or the management of conditions such as diabetes and obesity are preventive factors in Alzheimer's diseases [2].…”

Section: Introductionmentioning

confidence: 99%

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Schwannoma of Tibial Nerve; Diagnosis and Management: A Rare Case Report With Brief Review of Literature

Furnari¹,

Pappalardo²,

Jean³

2020

J Oncol Res Rev Rep

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Introduction: Schwannomas are benign, encapsulated, silent, and usually solitary tumors originating from Schwann cells of the peripheral nerve sheath. Tibial nerve Schwannomas are very rare hence we are reporting this case for the better understanding of this unusual clinical entity. Case Presentation: A 53-year-old male patient, truck- driver by occupation, arrived to our Plastic Surgery Department complaining of swelling, pain and paresthesia in the upper part of his right leg. These symptoms were present for about 8 months and were more apparent at the end of the day. There was no evidence of any other medical comorbidity like peripheral vascular disease. There was no history of prior traumatic events related to right lower limb. Thorough clinical examination and MRI supported the diagnosis of a benign peripheral nerve tumor and patient was treated by microsurgical excision of the lesion which completely relieved the patient’s symptoms. Discussion: Mechanical compression caused by the space occupying lesion resulted in aggravation of symptoms. Classical burning/shooting pain and paresthesia often manifested by nerve sheath tumors. An increase in intracompartmental pressure resulted in pressure over nerve which consequently led to episodic pattern of neurological symptoms (diurnal variation in pain and paresthesia). Microsurgical excision of the tumor cured the symptoms completely and again patient was able to resume his regular day- to- day activities without any discomfort. Conclusion: We describe a rare case of a patient with an unusual tibial nerve Schwannoma clinical presentation. Microsurgical excision of the space occupying lesion preserving the nerve fascicles play an important role in achieving the good post- surgical outcome. Medical literature on this topic is scarce hence this case report intends to add further data about such pathological conditions.

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Section: Luis Bunuelmentioning

confidence: 99%

Section: Anatomical Structuresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Schwannoma of Tibial Nerve; Diagnosis and Management: A Rare Case Report With Brief Review of Literature

Furnari¹,

Pappalardo²,

Jean³

2020

J Oncol Res Rev Rep

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Oestrogen Regulation of Sexual Behaviour, Mood and Cognition

Almeida¹,

Conde²,

Sousa³

2013

Encyclopedia of Life Sciences

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Oestrogens are steroid hormones that act through specific receptors in the brain to influence sexual behaviour, as well as mood and cognition. Oestrogen actions include alterations of neuronal excitability, neurotransmitter synthesis and metabolism, neuronal circuitry and neuronal survival, one or all of which may contribute to their effects on mood and cognition. Oestrogens act on a wide variety of peripheral tissues such as breast, bone, liver and heart tissues. Although they have found widespread use for the management of menopausal symptoms, the current consensus is that oestrogen replacement therapy should be used at the lowest possible doses, for a limited duration and with careful consideration of the individual woman's treatment goals and risks. Oestrogens regulate gene transcription, resulting in long‐lasting biochemical changes that can impact adversely on health. The development of improved selective oestrogen receptor modulators that target specific tissues may eventually help circumvent some of the undesired effects of oestrogens. Key Concepts: Oestrogens serve important physiological roles in the brain and in peripheral organ systems. Oestrogens and oestrogen‐like compounds bind to oestrogen receptors; oestrogen receptors occur as two isoforms, known as oestrogen receptor, ERα and ERβ Oestrogens modulate gene activity, cellular structure and function and ultimately, regulate complex behaviours after binding to specific oestrogen receptors in the brain. Oestrogen secretion starts during early development, varies cyclically from puberty onwards, and gradually diminishes with age (menopause in women). Oestrogen‐like compounds that raise health issues are increasingly found in our modern environment as well as in plants; the potency and safety of the latter, especially as dietary supplements, is however questionable. The therapeutic use of oestrogens in menopausal women should be tailored to an individual woman's needs and should be limited in order to avoid health‐related reductions in quality of life.

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Estrogen Influences on Cognition

Cited by 2 publications

References 157 publications

Schwannoma of Tibial Nerve; Diagnosis and Management: A Rare Case Report With Brief Review of Literature

Schwannoma of Tibial Nerve; Diagnosis and Management: A Rare Case Report With Brief Review of Literature

Oestrogen Regulation of Sexual Behaviour, Mood and Cognition

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