Estrogen induces shift in abundances of specific groups of the coral microbiome

Vilela, Caren L. S.; Villela, Helena; Duarte, Gabriela; Santoro, Erika P.; Rachid, Caio T. C. C.; Peixoto, Raquel S.

doi:10.1038/s41598-021-82387-x

Cited by 11 publications

(12 citation statements)

References 91 publications

(105 reference statements)

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“…The results showed that several classes of bacteria varied dynamically but remained dominant in different treatment groups, including Gammaproteobacteria and Alphaproteobacteria . E1 elicited a subsidy to the bacteria belonging to these classes, which could be supported by previous research regarding the bacterial degradation of estrogen ( Balcom et al, 2016 ; Mainetti et al, 2021 ; Vilela et al, 2021 ). The variation of bacterial community structure in water samples from different locations may be mainly due to the composition of the bacterial community structure in the in-situ water sample ( Ji et al, 2017 ).…”

Section: Discussionsupporting

confidence: 82%

“…These interference effects were assessed using several laboratory-scale microcosm or mesocosm experiments ( Yergeau et al, 2012 ; Guasch et al, 2016 ). Studies have also investigated the ecological mechanisms controlling microbial community assemblies and interspecies interactions in rivers, which have been disturbed anthropogenically ( Gad et al, 2020 ; Mainetti et al, 2021 ; Vilela et al, 2021 ). It has been suggested that estrogens and other endocrine disruptors have contrasting ecological effects on the aquatic microbiology community.…”

Section: Introductionmentioning

confidence: 99%

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Response and recovery mechanisms of river microorganisms to gradient concentrations of estrogen

Qin

Li²,

Chen³

et al. 2023

Front. Microbiol.

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As an important ecological system on the earth, rivers have been influenced by the rapid development of urbanization, industrialization, and anthropogenic activities. Increasingly more emerging contaminants, such as estrogens, are discharged into the river environment. In this study, we conducted river water microcosmic experiments using in situ water to investigate the response mechanisms of microbial community when exposed to different concentrations of target estrogen (estrone, E1). Results showed that both exposure time and concentrations shaped the diversity of microbial community when exposed to E1. Deterministic process played a vital role in influencing microbial community over the entire sampling period. The influence of E1 on microbial community could last for a longer time even after the E1 has been degraded. The microbial community structure could not be restored to the undisturbed state by E1, even if disturbed by low concentrations of E1(1 μg/L and 10 μg/L) for a short time. Our study suggests that estrogens could cause long-term disturbance to the microbial community of river water ecosystem and provides a theoretical basis for assessing the environmental risk of estrogens in rivers.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Response and recovery mechanisms of river microorganisms to gradient concentrations of estrogen

Qin

Li²,

Chen³

et al. 2023

Front. Microbiol.

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“…Ethinyl-estradiol (EE2) is another estrogen receptor agonist that has been tested in zebrafish. EE2 is a synthetic derivative of endogenous E2 and, due to its wide use as a constituent in oral contraceptives, reaches aquatic environments through wastewater effluents ( Vilela et al, 2021 ); agricultural and aquaculture runoff are other sources ( Tang et al, 2021 ). EE2 concentration in surface waters varies, ranging up to 62 ng/L ( Versonnen and Janssen, 2004 ), and it is consistently identified worldwide make it a serious environmental contaminant ( Tang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

The Role of Estrogen and Thyroid Hormones in Zebrafish Visual System Function

et al. 2022

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Visual system development is a highly complex process involving coordination of environmental cues, cell pathways, and integration of functional circuits. Consequently, a change to any step, due to a mutation or chemical exposure, can lead to deleterious consequences. One class of chemicals known to have both overt and subtle effects on the visual system is endocrine disrupting compounds (EDCs). EDCs are environmental contaminants which alter hormonal signaling by either preventing compound synthesis or binding to postsynaptic receptors. Interestingly, recent work has identified neuronal and sensory systems, particularly vision, as targets for EDCs. In particular, estrogenic and thyroidogenic signaling have been identified as critical modulators of proper visual system development and function. Here, we summarize and review this work, from our lab and others, focusing on behavioral, physiological, and molecular data collected in zebrafish. We also discuss different exposure regimes used, including long-lasting effects of developmental exposure. Overall, zebrafish are a model of choice to examine the impact of EDCs and other compounds targeting estrogen and thyroid signaling and the consequences of exposure in visual system development and function.

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“…The overall bacterial diversity was assessed by hightrough-put sequencing using the platform Illumina MiSeq (Illumina, San Diego, CA, USA at the Argonne National Laboratory, http://ngs.igsb.anl.gov (accessed on 2 March 2017), Lemont, IL, USA) with paired-end strategy, following the manufacturer's guidelines. The raw sequences were processed using Mothur v.1.39.1 software [68], as described in [69]. Briefly, Greengenes database (version from August 2013) was used with an 80% confidence threshold, and sequences classified as Chloroplasts, Mitochondria, Archaea, Eukarya, or not assigned to any kingdom were removed.…”

Section: Bacterial Composition By 16s Rrna Gene Sequencingmentioning

confidence: 99%

Exploring the Diversity and Biotechnological Potential of Cultured and Uncultured Coral-Associated Bacteria

et al. 2021

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Coral-associated microbes are crucial for the biology of their hosts, contributing to nutrient cycling, adaptation, mitigation of toxic compounds, and biological control of pathogens. Natural products from coral-associated micro-organisms (CAM) may possess unique traits. Despite this, the use of CAM for biotechnological purposes has not yet been adequately explored. Here, we investigated the production of commercially important enzymes by 37 strains of bacteria isolated from the coral species Mussismilia braziliensis, Millepora alcicornis, and Porites astreoides. In-vitro enzymatic assays showed that up to 56% of the isolates produced at least one of the seven enzymes screened (lipase, caseinase, keratinase, cellulase, chitinase, amylase, and gelatinase); one strain, identified as Bacillus amyloliquefaciens produced all these enzymes. Additionally, coral species-specific cultured and uncultured microbial communities were identified. The phylum Firmicutes predominated among the isolates, including the genera Exiguobacterium, Bacillus, and Halomonas, among others. Next-generation sequencing and bacteria culturing produced similar but also complementary data, with certain genera detected only by one or the other method. Our results demonstrate the importance of exploring different coral species as sources of specific micro-organisms of biotechnological and industrial interest, at the same time reinforcing the economic and ecological importance of coral reefs as reservoirs of such diversity.

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Estrogen induces shift in abundances of specific groups of the coral microbiome

Cited by 11 publications

References 91 publications

Response and recovery mechanisms of river microorganisms to gradient concentrations of estrogen

Response and recovery mechanisms of river microorganisms to gradient concentrations of estrogen

The Role of Estrogen and Thyroid Hormones in Zebrafish Visual System Function

Exploring the Diversity and Biotechnological Potential of Cultured and Uncultured Coral-Associated Bacteria

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