Estrogen-induced neuroimmunomodulation as facilitator of and barrier to reproductive aging in brain and lymphoid organs

ThyagaRajan, Srinivasan; Hima, Lalgi; Pratap, Uday P.; Priyanka, Hannah P.; Vasantharekha, Ramasamy

doi:10.1016/j.jchemneu.2018.02.008

Cited by 15 publications

(3 citation statements)

References 51 publications

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“…Reproductive aging in females is marked by alterations in gonadal hormones, estrogen, and progesterone that fa- cilitate the cessation of reproductive cycles and onset of female-specific diseases [24]. Therefore, we examined the level of E 2 with the presence and absence of LIPUS as well.…”

Section: Ementioning

confidence: 99%

Potential Application of Low-Intensity Pulsed Ultrasound in Delaying Aging for Mice

Wang¹,

Li²,

Xia³

et al. 2021

Gerontology

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Introduction: The low-intensity pulsed ultrasound (LIPUS) is one of the popular treatment modalities allowing to boost the proliferation, differentiation, and migratory activity of cells, which might be a powerful strategy for anti-aging. Seeking a novel setup for LIPUS would benefit the development of ultrasound therapeutics. Methods: Here, we proposed a novel underwater exposure setup of LIPUS. C57BL/6 mice were reared in the designated age-groups, which consisted of a middle-aged group (12–14 months) and an old-age group (20–23 months). The age-related changes of body composition, imbalance of energy supply and demand, imbalance of signal network maintaining internal stability, and representative phenotypes of neurodegeneration and neuroplasticity with the presence and absence of underwater LIPUS in middle-aged and aged groups were evaluated. Results: The results showed that there were obvious aging changes, imbalance of energy supply and demand, imbalance of signal network maintaining homeostasis, neurodegeneration, and damage of neural plasticity in the middle-aged and aged group with or without the LIPUS. Although middle-aged group and aged group responded differently to LIPUS, they mostly generated positive results in relieving bone loss, improving ovarian structure, regulated immune system, and enhanced endurance ability, which should have declined over age. Discussion: These findings indicate that underwater extracorporeal LIPUS exposure could be employed as single or combined anti-aging strategies that generated positive outcomes against the process of aging.

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Section: Ementioning

confidence: 99%

Potential Application of Low-Intensity Pulsed Ultrasound in Delaying Aging for Mice

Wang¹,

Li²,

Xia³

et al. 2021

Gerontology

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“…The ovaries primarily produce oestrogens and progestins, and the principal products of testes are androgens. Gonadal hormones have multivariate impacts on reproduction, endocrine function, metabolism, immunity and the function of the central nervous system [ 11 , 12 ]. Cyclical changes in the levels of endogenous sex hormones in women create the follicular (pre-ovulation) and luteal (post-ovulation) phases of the menstrual cycle.…”

Section: The Effect Of Gonadal Steroids On Opioid-mediated Analgesiamentioning

confidence: 99%

The role of gonadal hormones in regulating opioid antinociception

Xu,

Jin,

Wang

et al. 2024

Annals of Medicine

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Opioids are the most prescribed drugs for the alleviation of pain. Both clinical and preclinical studies have reported strong evidence for sex-related divergence regarding opioid analgesia. There is an increasing amount of evidence indicating that gonadal hormones regulate the analgesic efficacy of opioids. This review presents an overview of the importance of gonadal steroids in modulating opioid analgesic responsiveness and focuses on elaborating what is currently known regarding the underlyingmechanism. We sought to identify the link between gonadal hormones and the effect of oipiod antinociception.

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“…Gonadal hormone levels are also closely related to aging [10]. Estrogen and androgen can regulate thymus development, which has been widely reported [11,12].…”

Section: Introductionmentioning

confidence: 97%

Effects of Castration on miRNA, lncRNA, and mRNA Profiles in Mice Thymus

Zhang

et al. 2020

Genes

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Thymic degeneration and regeneration are regulated by estrogen and androgen. Recent studies have found that long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are involved in organ development. In this study, RNA sequencing (RNA-seq) results showed that ovariectomy significantly affected 333 lncRNAs, 51 miRNAs, and 144 mRNAs levels (p < 0.05 and |log2fold change| > 1), and orchiectomy significantly affected 165 lncRNAs, 165 miRNAs, and 208 mRNA levels in the thymus. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that differentially expressed genes (DEGs) were closely related to cell development and immunity. Next, we constructed two lncRNA–miRNA–mRNA networks using Cytoscape based on the targeting relationship between differentially expressed miRNAs (DEMs) and DEGs and differentially expressed lncRNAs (DELs) analyzed by TargetScan and miRanda. Besides, we screened DEGs that were significantly enriched in GO and in ceRNA networks to verify their expression in thymocytes and thymic epithelial cells (TECs). In addition, we analyzed the promoter sequences of DEGs, and identified 25 causal transcription factors. Finally, we constructed transcription factor-miRNA-joint target gene networks. In conclusion, this study reveals the effects of estrogen and androgen on the expression of miRNAs, lncRNAs, and mRNAs in mice thymus, providing new insights into the regulation of thymic development by gonadal hormones and non-coding RNAs.

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Estrogen-induced neuroimmunomodulation as facilitator of and barrier to reproductive aging in brain and lymphoid organs

Cited by 15 publications

References 51 publications

Potential Application of Low-Intensity Pulsed Ultrasound in Delaying Aging for Mice

Potential Application of Low-Intensity Pulsed Ultrasound in Delaying Aging for Mice

The role of gonadal hormones in regulating opioid antinociception

Effects of Castration on miRNA, lncRNA, and mRNA Profiles in Mice Thymus

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