Estrogen increases the expression of BKCa and impairs the contraction of colon smooth muscle via upregulation of sphingosine kinase 1
Yan Wang,
Ya Jiang,
Ling Jiang
et al.
Abstract:Estrogen (E2) may impair the contraction of colonic smooth muscle (SM) leading to constipation. Large conductance Ca2+‐activated K+ channels (BKCa) are widely expressed in the smooth muscle cells (SMCs) contributing to hyperpolarization and relaxation of SMCs. Sphingosine kinase 1 (SphK1) is known to influence the expression of BKCa. We aimed to elucidate the potential underlying molecular mechanism of BKCa and SphK1 that may influence E2‐induced colonic dysmotility.In ovariectomized rats, SM contraction and e… Show more
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