Estrogen Impacts on Emotion: Psychological, Neuroscience and Endocrine Studies

Chen, ChunPing; Cheng, Dazhi; Luo, Yuejia

doi:10.1360/052011-369

Cited by 5 publications

(3 citation statements)

References 97 publications

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“…As well as hormonal changes during the menstrual cycle having an influence on female cognition (e.g., humans: Bayer et al., 2014; review: Chen et al., 2011), age at puberty could also be more important than hormone levels (e.g., humans: Hirtz et al., 2022). However, puberty may not have occurred during the 9–11‐month cognitive testing period (puberty = 10–13 months in marmosets: Abbott & Hearn, 1978).…”

Section: Discussionmentioning

confidence: 99%

Cognitive development from infancy to young adulthood in common marmosets (Callithrix jacchus): Effect of age, sex, and hormones on learning and affective state

Ash,

Goy,

Spaulding

et al. 2023

Developmental Psychobiology

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Studies looking at individual variability in cognition have increased in recent years. We followed 43 marmosets (21 males, 22 females) from infancy to young adulthood. At 3‐months old, marmosets were trained to touch a rewarded stimulus. At 9‐, 15‐, and 21‐months old, they were given visual discrimination and cognitive bias tests, and urine samples were collected to examine hormone levels. Marmosets were significantly more successful learners at 15 months than 9 months. Individuals who were more successful learners at 9 months were also more successful at 15 months, with more male learners than expected at 15 months. At 9 months, learning success was associated with higher cortisol levels. At 15 months, males with higher estradiol levels were more successful learners, whereas at 21 months, females with higher estradiol and cortisol levels tended to be less successful learners and more pessimistic. Nine months, therefore, appears to be an important developmental timepoint for acquiring cognitive control, which has developed by 15 months. Steroids may have differential effects on each sex, with complex interactions between gonadal and adrenal hormones having an influence on cognitive function over the lifespan. This longitudinal study offers new insight into cognition, including its development and biological underpinnings.

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Section: Discussionmentioning

confidence: 99%

Cognitive development from infancy to young adulthood in common marmosets (Callithrix jacchus): Effect of age, sex, and hormones on learning and affective state

Ash,

Goy,

Spaulding

et al. 2023

Developmental Psychobiology

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“…The women who suffer from PMS are often affected by negative emotions like anxiety, depression and irritability [ 4 ]. It has been indicated that most of these premenstrual complaints reported by women with PMDD are related to heightened stress-sensitivity [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Abnormal Resting-State Connectivity at Functional MRI in Women with Premenstrual Syndrome

Liu

Zhou³

et al. 2015

PLoS ONE

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ObjectivesPremenstrual syndrome (PMS) refers to a series of cycling and relapsing physical, emotion and behavior syndromes that occur in the luteal phase and resolve soon after the onset of menses. Although PMS is widely recognized, its neural mechanism is still unclear.DesignTo address this question, we measured brain activity for women with PMS and women without PMS (control group) using resting-state functional magnetic resonance imaging (rs-fMRI). In addition, the participants should complete the emotion scales (Beck Anxiety Inventory, BAI; Beck Depression Inventory, BDI, before the scanning) as well as the stress perception scale (Visual analog scale for stress, VAS, before and after the scanning).ResultsThe results showed that compared with the control group, the PMS group had decreased connectivity in the middle frontal gyrus (MFG) and theparahippocampalgyrus (PHG), as well as increased connectivity in the left medial/superior temporal gyri (MTG/STG) and precentralgyrus within the default mode network (DMN); in addition, the PMS group had higher anxiety and depression scale scores, together with lower stress perception scores. Finally, there were significantly positive correlations between the stress perception scores and functional connectivity in the MFG and cuneus. The BDI scores in the PMS group were correlated negatively with the functional connectivity in the MFG and precuneus and correlated positively with the functional connectivity in the MTG.ConclusionThese findings suggest that compared with normal women, women with PMS displayed abnormal stress sensitivity, which was reflected in the decreased and increased functional connectivity within the DMN, blunted stress perception and higher depression.

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“…This may be related to prolonged high-intensity exercise that may cause excessive fatigue in the body, which may lead to HPG axis dysfunction and reduce E 2 in the serum of female mice ( Schmitz et al, 2015 ). When level of estrogen in women's body is low, stress response is enhanced levels of estrogen is negatively correlated with stress response ( Chen et al, 2011 ). Therefore, high-intensity exercise may be a stress in mice to change E 2 levels in the serum, thereby increasing anxiety levels.…”

Section: Discussionmentioning

confidence: 99%

Effects of treadmill exercise on anxiety-like behavior in association with changes in estrogen receptors ERα, ERβ and oxytocin of C57BL/6J female mice

Fan

Hui

et al. 2021

IBRO Neuroscience Reports

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Exercise can reduce the incidence of stress-related mental diseases, such as depression and anxiety. Control group was neither exposed to CVMS nor TRE (noCVMS/noTRE). Females were tested and levels of serum17-beta-oestradiol (E 2 ), estrogen receptors α immunoreactive neurons (ERα-IRs), estrogen receptors β immunoreactive neurons (ERβ-IRs) and oxytocin immunoreactive neurons (OT-IRs) were measured. The results showed there’s increased anxiety-like behaviors for mice from CVMS/noTRE, CVMS/higher speed TRE (CVMS/HTRE) and noCVMS/HTRE groups when they were put in open field and elevated maze tests. They had lower serum E 2 levels than mice from CVMS/low-moderate speed TRE (CVMS/LMTRE), noCVMS/LMTRE and noCVMS/noTRE groups. The three groups of CVMS/noTRE, CVMS/HTRE and noCVMS/HTRE mice had more ERα-IRs and less ERβ-IRs in the medial preoptic area (mPOA), bed nucleus of the stria terminalis (BNST) and medial amygdala (MeA), hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON). The number of OT-IRs in PVN and SON of CVMS/noTRE, CVMS/HTRE and noCVMS/HTRE mice was also lower than that of mice from CVMS/LMTRE, noCVMS/LMTRE and noCVMS/noTRE groups. Interestingly, CVMS/LMTRE and noCVMS/LMTRE mice were similar to noCVMS/noTRE mice in that they did not show anxiety, while CVMS/HTRE and noCVMS/HTRE mice did not, which were similar to the mice in CVMS/noTRE. We propose that LMTRE instead of HTRE changes the serum concentration of E 2 . ERβ/ERα ratio and OT level in the brain may be responsible for the decrease in anxiety-like behavior in female mice exposed to anxiety-inducing stress conditions.

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Estrogen Impacts on Emotion: Psychological, Neuroscience and Endocrine Studies

Cited by 5 publications

References 97 publications

Cognitive development from infancy to young adulthood in common marmosets (Callithrix jacchus): Effect of age, sex, and hormones on learning and affective state

Cognitive development from infancy to young adulthood in common marmosets (Callithrix jacchus): Effect of age, sex, and hormones on learning and affective state

Abnormal Resting-State Connectivity at Functional MRI in Women with Premenstrual Syndrome

Effects of treadmill exercise on anxiety-like behavior in association with changes in estrogen receptors ERα, ERβ and oxytocin of C57BL/6J female mice

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