Estrogen Enhances Angiogenesis through a Pathway Involving Platelet-Activating Factor-Mediated Nuclear Factor-κB Activation

Seo, Kook Heon; Lee, Hyun-Suk; Jung, Bongnam; Ko, Hyun-Mi; Choi, Jung-Hwa; Park, Sung Jun; Choi, Il-Hwan; Lee, Hern-Ku; Im, Suhn-Young

doi:10.1158/0008-5472.can-03-2774

Cited by 58 publications

(50 citation statements)

References 50 publications

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“…In other clinical studies, resistin have been associated with inflammatory markers apparently independent on BMI, but related to risk factors of atherosclerosis [31,32]. Together with facts that up-regulated pro-inflammatory cytokines and chemokines in tumors [33][34][35] and inflammation itself is recently recognized as risk factor contributing on cancer development and progression [36][37][38][39], resistin seems to be a novel secreted protein in relation to inflammation in humans and may present molecular link between inflammation and carcinogenesis.…”

Section: Discussionmentioning

confidence: 80%

Relationship of resistin levels with endometrial cancer risk

Hlavna

Kohut²,

Lipková³

et al. 2011

neo

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Cancer of endometrium (CAE) is the most common gynecologic malignancy in industrialized nations. Increased resistin levels, an adipocytokine produced by adipose tissue and macrophages, have been considered as a risk factor in gastric, colon and breast cancer, recently. No studies associating resistin levels with endometrial cancer have been done so far. The purpose of this case-control study was to determine the relationship between serum circulating resistin levels and resistin gene -420C>G (rs3219175) variant in endometrial cancer patients. 37 Caucasian female patients and 39 healthy controls were enrolled in this study. Difference in resistin levels between age and BMI matched patients group (mean 24.2 ng/ml) and control subjects (mean 10.1 ng/ml) were statistically significant (p < 0.01). We also determined single nucleotide polymorphism -420C>G (rs3219175) within resistin gene and no significant association between resistin levels and investigated polymorphism was found. Furthermore, no significant association between higher resistin levels and diabetes mellitus 2, body mass index, smoking or age have been observed within studied groups. To our knowledge, this is the first study examining the relationship between serum resistin levels and endometrial cancer and our results show, that patients with endometrial cancer have significantly increased circulating levels of resistin compared to control subjects.

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Section: Discussionmentioning

confidence: 80%

Relationship of resistin levels with endometrial cancer risk

Hlavna

Kohut²,

Lipková³

et al. 2011

neo

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“…38,58 Moreover, estrogen has also been shown to enhance angiogenesis via platelet factor-mediated activation of NF-κB, leading to the production of IL-8, bFGF and VEGF. 57 On the other hand, the endogenous estrogen metabolite, 2-methoxyestradiol has been reported to inhibit endothelial cell proliferation, as well as angiogenesis, tumor growth and metastasis in several tumor types, including melanoma. 16,20,52 Medroxyprogesterone also inhibited growth and vascularization of melanoma in the rabbit cornea.…”

Section: Kiss Et Al Pathology Oncology Researchmentioning

confidence: 99%

Association of microvessel density with infiltrating cells in human cutaneous malignant melanoma

Kiss

Tı́már

Somlai

et al. 2007

Pathol. Oncol. Res.

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“…Estrogens have a well established pro-angiogenesis function, best known in the endometrium during the female reproductive cycle, which is mediated by enhancement of endothelial cell proliferation and migration 30,53 . This is mediated by diffusible factors like PAF 54 and VEGF 55 , which are frequently secreted by cancer cells in response to estrogens. In contrast to ERα, ERβ activation in neoplastic breast cells negatively affects blood vessel formation 56 .…”

Section: Introduction (Epidemiology)mentioning

confidence: 99%

Sexual dimorphism in cancer

et al. 2016

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The incidence of many cancer types is significantly higher in the male than female populations, with associated differences in survival. Occupational and/or behavioral factors are well known underlying determinants. However, cellular/molecular differences between the two sexes are also likely to be important. We are focusing here on the complex interplay that sexual hormones and sex chromosomes can have in intrinsic control of cancer initiating cell populations, tumor microenvironment and systemic determinants of cancer development like the immune system and metabolism. A better appreciation of these differences between the two sexes could be of substantial value for cancer prevention as well as treatment.3 Introduction (Epidemiology)

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Estrogen Enhances Angiogenesis through a Pathway Involving Platelet-Activating Factor-Mediated Nuclear Factor-κB Activation

Abstract: ABSTRACT

Cited by 58 publications

References 50 publications

Relationship of resistin levels with endometrial cancer risk

Relationship of resistin levels with endometrial cancer risk

Association of microvessel density with infiltrating cells in human cutaneous malignant melanoma

Sexual dimorphism in cancer

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