Estrogen-dependent effects of 5-hydroxytryptophan on cortical spreading depression in rat: Modelling the serotonin-ovarian hormone interaction in migraine aura

Chauvel, Virginie; Multon, Sylvie; Schoenen, Jean

doi:10.1177/0333102417690891

Cited by 26 publications

(24 citation statements)

References 52 publications

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“…Administration of the serotonin precursor 5-hydroxytryptophan in animal models has also been shown to decrease the frequency of KCl-induced SD in female rats, suggesting a possible role for serotonergic agents as therapeutic tools in migraine with aura in females ( 109 ). Blocking the SD mechanism, therefore, seems to be a rational approach to explore in molecular research aimed at improving the prevention and treatment of migraine with aura.…”

Section: Sd In Disease Conditionsmentioning

confidence: 99%

Understanding Spreading Depression from Headache to Sudden Unexpected Death

et al. 2018

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Spreading depression (SD) is a neurophysiological phenomenon characterized by abrupt changes in intracellular ion gradients and sustained depolarization of neurons. It leads to loss of electrical activity, changes in the synaptic architecture, and an altered vascular response. Although SD is often described as a unique phenomenon with homogeneous characteristics, it may be strongly affected by the particular triggering event and by genetic background. Furthermore, SD may contribute differently to the pathogenesis of widely heterogeneous clinical conditions. Indeed, clinical disorders related to SD vary in their presentation and severity, ranging from benign headache conditions (migraine syndromes) to severely disabling events, such as cerebral ischemia, or even death in people with epilepsy. Although the characteristics and mechanisms of SD have been dissected using a variety of approaches, ranging from cells to human models, this phenomenon remains only partially understood because of its complexity and the difficulty of obtaining direct experimental data. Currently, clinical monitoring of SD is limited to patients who require neurosurgical interventions and the placement of subdural electrode strips. Significantly, SD events recorded in humans display electrophysiological features that are essentially the same as those observed in animal models. Further research using existing and new experimental models of SD may allow a better understanding of its core mechanisms, and of their differences in different clinical conditions, fostering opportunities to identify and develop targeted therapies for SD-related disorders and their worst consequences.

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Section: Sd In Disease Conditionsmentioning

confidence: 99%

Understanding Spreading Depression from Headache to Sudden Unexpected Death

et al. 2018

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“…These findings may explain why migraine aura can emerge with pregnancy as estrogen levels rise and why MRM is rarely associated with MA. 39 This study built upon work which had demonstrated that enzymes involved in the synthesis of serotonin are expressed in mouse trigeminal ganglion, and the level of these enzymes is dependent on the gender and estrus cycle stage, suggesting that ovarian steroids might play a role in the regulation of serotonin synthesis. 40…”

Section: Pathophysiology Of Migrainementioning

confidence: 99%

Migraine in Women

2017

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Migraine is one of the most common neurological disorders, affecting women disproportionally at a rate of 3:1. Prior to puberty, boys and girls are equally affected, but the female preponderance emerges after puberty. Migraine pathophysiology is not fully understood, and although the hormonal effect of estrogen is significant, other factors are at play. This article will focus on the hormonal influence on migraine in women. Here we review our most recent understanding of migraine and menstrual migraine, including epidemiology, pathophysiology, and treatment strategies for this challenging disorder, as well as migraine during pregnancy, postpartum period, breastfeeding, perimenopause, and menopause. We also review the risks and benefits of exogenous hormone use in this population and discuss stroke risk in women with migraine aura. By understanding these aspects of migraine in women, we hope to arm practitioners with the knowledge and tools to help guide treatment of this debilitating disorder in this large population.

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“…In high oestrogen states, such as pregnancy and during use of the combined oral contraceptive pill or high-dose hormone replacement therapy, aura can be triggered; conversely, a decline in oestrogen concentration is associated with exacerbations of migraine without aura, probably by reducing the migraine attack threshold or by directly triggering attacks 9. Animal studies support the association between high oestrogen states and aura in that oestrogen increases the susceptibility to cortical spreading depression, the pathophysiological correlate of migraine aura 10. This phenomenon is thought to be glutaminergic 11…”

Section: Pathophysiologymentioning

confidence: 97%

Migraine: navigating the hormonal minefield

Afridi

2019

Pract Neurol

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Migraine affects 959 million people worldwide,1 with the highest prevalence being in women of childbearing age. The interplay between female hormones and migraine can be a challenging area to navigate since issues relating to pregnancy, contraception and the menopause are often out of the neurology comfort zone. This review aims to help the neurologist to manage women with migraine, from menarche to menopause.

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Estrogen-dependent effects of 5-hydroxytryptophan on cortical spreading depression in rat: Modelling the serotonin-ovarian hormone interaction in migraine aura

Cited by 26 publications

References 52 publications

Understanding Spreading Depression from Headache to Sudden Unexpected Death

Understanding Spreading Depression from Headache to Sudden Unexpected Death

Migraine in Women

Migraine: navigating the hormonal minefield

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