Estrogen dependent ciliogenesis in the chick oviduct

Anderson, Richard G. W.; Hein, C.

doi:10.1007/bf00220238

Cited by 25 publications

(14 citation statements)

References 11 publications

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“…Thus, consistent with previous reports of foxj1 function and the absence of cilia in the oviduct in foxj1 null mice, our findings indicate a key role for foxj1 in the ciliogenesis of the oviduct. Also considered were previous reports that indicated that estrogen signaling may be critical for ciliogenesis, thereby suggesting that E2 could activate foxj1 (Anderson & Hein 1976, Eroschenko 1982, Jansen 1984, Abe & Oikawa 1993, Comer et al 1998.…”

Section: Discussionmentioning

confidence: 99%

“…Several experimental models have shown that oviductal development is regulated by the ovarian sex steroid hormones estrogen and progesterone (Jansen 1984). In the chick and mouse oviduct, estradiol-17 (E2) induces epithelial cell proliferation and differentiation (Anderson & Hein 1976). In this regard, the differentiation of the secretory epithelial cell phenotype to the ciliated epithelial cell phenotype can be induced by E2 in primary cultured human fallopian tube epithelial cells (Comer et al 1998).…”

Section: Introductionmentioning

confidence: 99%

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Role of foxj1 and estrogen receptor alpha in ciliated epithelial cell differentiation of the neonatal oviduct

Okada¹,

Ohta²,

Brody³

et al. 2004

Journal of Molecular Endocrinology

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Estrogen regulates proliferation and differentiation of epithelial cells in the mammalian oviduct, but pathways for cell-specific differentiation are not well understood. In the epithelial cells of the developing rat oviduct, we found estrogen receptor (ER) is expressed at birth and persists in all cells through neonatal day (ND) 7 when ciliated cells appear. To determine a specific function of ER and foxj1, a transcription factor known to have fundamental roles in ciliogenesis in the lung, in differentiation of the ciliated epithelial cells, we treated newborn rats from ND 0 to 5 with estradiol-17 (E2) with and without a selective ER antagonist. E2 enhanced the number of proliferating cells and accelerated the process of epithelial cell differentiation resulting in ciliogenesis by ND 5, and co-treatment with an ER antagonist inhibited these changes. Foxj1 was expressed only in the infundibulum and ampulla (INF/AMP). That expression preceded the appearance of cilia and was induced by E2. Cilia were absent in oviducts of foxj1-deficient mice, indicating that foxj1 plays a critical role in oviductal ciliogenesis. However, we found the presence of cilia in the ER -deficient mouse oviduct. The widespread expression of ER in oviductal epithelium, but restriction of cilia to the INF/AMP regions, and importantly, the presence of cilia in the ER -deficient mice, suggested ER signaling is not essential for ciliated epithelial cell differentiation. These observations demonstrate that, although E2 stimulates the differentiation process of ciliated epithelial cells, foxj1 is directly required for epithelial cell ciliogenesis of the neonatal oviduct.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of foxj1 and estrogen receptor alpha in ciliated epithelial cell differentiation of the neonatal oviduct

Okada¹,

Ohta²,

Brody³

et al. 2004

Journal of Molecular Endocrinology

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“…Perinatal exposure to DES induced cell proliferation and caused abnormal morphology in mouse and rat oviducts (Newbold et al 1983, Okada et al 2001. Also, in immature chicks, E2 induced cell proliferation in the oviductal epithelium (Anderson & Hein 1976). However, unlike in the uterus, the effects of E2 on the expression of AP-1 transcription factors have not been reported in the mammalian oviduct, but only in the immature chick oviduct whose c-jun and c-fos were rather reduced, with increased ovalbumin production, after E2 treatment (Cohrs et al 1988, Lau et al 1990.…”

Section: Introductionmentioning

confidence: 99%

Epithelial c-jun and c-fos are temporally and spatially regulated by estradiol during neonatal rat oviduct differentiation

Okada¹,

Ohta²,

Brody³

et al. 2004

Journal of Endocrinology

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Expression of transcription factors binding to the activating protein-1 (AP-1) site is induced by estrogens in association with epithelial proliferation in the uterus, but, in the oviduct, the relationship between cell proliferation and differentiation and AP-1 transcription factors is not well understood. In the developing rat oviduct, we found that proliferation and differentiation of epithelial cells were region-dependently regulated by 17 -estradiol (E2). To determine the role of AP-1 transcription factors in the development of rat oviduct, we performed immunohistochemistry for epithelial c-jun and c-fos proteins in E2-untreated and -treated newborn rats. E2 increased the expression of c-jun and c-fos during proliferation of undifferentiated epithelial cells, but diminished both proteins during accelerated differentiation of ciliated epithelial cells. A pure estrogen receptor (ER) antagonist, ICI 182,780, inhibited changes in their expression during both cell proliferation and differentiation. Importantly, no reduction of c-jun was noted in the epithelial cells of the foxj1-deficient oviduct, which lacks cilia development. This study shows that c-jun and c-fos are regulated during epithelial cell proliferation and differentiation in a regionspecific manner. This provides critical information for understanding the molecular and cellular mechanisms of the development of the neonatal oviduct.

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“…In fact, ciliogenesis produced by oestrogen administration has been reported in various animals (6).…”

Section: Discussionmentioning

confidence: 99%

Ciliated Cyst of the Vulva: Oestrogen and Progesterone Receptors

Kuniyuki¹,

Fukushima²,

Yoshida³

et al. 2008

Acta Derm Venerol

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Estrogen dependent ciliogenesis in the chick oviduct

Cited by 25 publications

References 11 publications

Role of foxj1 and estrogen receptor alpha in ciliated epithelial cell differentiation of the neonatal oviduct

Role of foxj1 and estrogen receptor alpha in ciliated epithelial cell differentiation of the neonatal oviduct

Epithelial c-jun and c-fos are temporally and spatially regulated by estradiol during neonatal rat oviduct differentiation

Ciliated Cyst of the Vulva: Oestrogen and Progesterone Receptors

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