Estrogen-Dependent Changes in Dura Mater Microvasculature Add New Insights to the Pathogenesis of Headache

Glinskii, Olga V.; Huxley, Virginia H.; Glinsky, Vladislav V.

doi:10.3389/fneur.2017.00549

Cited by 8 publications

(5 citation statements)

References 59 publications

(77 reference statements)

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“…A drop in estrogen may cause an increased sensitivity to prostaglandins and a release of neuropeptides such as CGRP, substance P and neurokinins which could result in neurogenic inflammation [17]. This physiological response provokes alterations in the microvasculature of the dura mater, changes in calcium and magnesium concentrations, and an imbalance in serotonin and dopamine concentrations [17, 21, 50]. Estrogen withdrawal might lead to an increased oxidative stress in the cells [51].…”

Section: Resultsmentioning

confidence: 99%

Male and female sex hormones in primary headaches

et al. 2018

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BackgroundThe three primary headaches, tension-type headache, migraine and cluster headache, occur in both genders, but all seem to have a sex-specific prevalence. These gender differences suggest that both male and female sex hormones could have an influence on the course of primary headaches. This review aims to summarise the most relevant and recent literature on this topic.MethodsTwo independent reviewers searched PUBMED in a systematic manner. Search strings were composed using the terms LH, FSH, progesteron*, estrogen*, DHEA*, prolactin, testosterone, androgen*, headach*, migrain*, “tension type” or cluster. A timeframe was set limiting the search to articles published in the last 20 years, after January 1st 1997.ResultsMigraine tends to follow a classic temporal pattern throughout a woman’s life corresponding to the fluctuation of estrogen in the different reproductive stages. The estrogen withdrawal hypothesis forms the basis for most of the assumptions made on this behalf. The role of other hormones as well as the importance of sex hormones in other primary headaches is far less studied.ConclusionThe available literature mainly covers the role of sex hormones in migraine in women. Detailed studies especially in the elderly of both sexes and in cluster headache and tension-type headache are warranted to fully elucidate the role of these hormones in all primary headaches.

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Section: Resultsmentioning

confidence: 99%

Male and female sex hormones in primary headaches

et al. 2018

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“…Positioned inside the intracranial cavity, an indistensible closed space, the dura mater not only protects intracranial structures, but also represents the critical site for CSF turnover (Dandy, 1929; Papaiconomou et al, 2004; Mack et al, 2009) and the main route for the brain venous/CSF outflow. Further, given these anatomical traits and location, there is a reason to believe that alterations within vascular networks into, and particularly out of the CNS within the cranial dura mater are significant, yet unappreciated initiators and/or contributors to a myriad neurological disorders including migraine (Glinskii et al, 2017), dural aneurysms (Baltsavias et al, 2015a, b) leading to a higher risk of intracranial hemorrhage, dural sinus/cerebral vein thrombosis (Baltsavias et al, 2015a, c), multiple sclerosis (Louveau et al, 2016), and Alzheimer’s disease (Louveau et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Complex Non-sinus-associated Pachymeningeal Lymphatic Structures: Interrelationship With Blood Microvasculature

et al. 2019

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The contribution of cranial dura mater vascular networks, as means for maintaining brain fluid movement and balance, and as the source of significant initiators and/or contributors to neurological disorders, has been overlooked. These networks consist of both blood and lymphatic vessels. The latter were discovered recently and described as sinus-associated structures thus changing the old paradigm that central nervous system lacks lymphatics. In this study, using markers specific to blood and lymphatic endothelia, we demonstrate the existence of the complex non-sinus-associated pachymeningeal lymphatic vasculature. We further show the interrelationship and possible connections between lymphatic vessels and the dural blood circulatory system. Our novel findings reveal the presence of lymphatic-like structures that exist on their own and/or in close proximity to microvessels. Of particular interest are sub-sets of vascular complexes with dual (lymphatic and blood) vessel identity representing a unique microenvironment within the cranial dura. The close association of the systemic blood circulation and meningeal lymphatics achieved in these complexes could facilitate fluid exchange between the two compartments and constitute an alternative route for CSF drainage.

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“…This early inflammatory process is mediated by sensory neurotransmitters released from the trigeminal neurons [ 35 ] also supplying sensory innervation to both vascular and stromal dural territories [ 36 , 37 ]. We speculate that early dural responses to corneal injury, which require separate investigation, most likely involve a cascade of events within highly innervated and vascularized dura mater connective tissue and depends on the local distribution of meningeal perivascular or stromal nociceptors [ 38 ]. It has been reported that CGRP (calcitonin gene-related peptide) or SP (substance P) neuropeptide release from activated nociceptors is associated with vasodilation, plasma protein leakage, extravasation of leukocytes, tissue swelling, mast cell activation [ 39 ] and augmented mechanosensitivity [ 40 ] leading to the impaired meningeal vascular integrity.…”

Section: Discussionmentioning

confidence: 99%

Corneal injury is associated with stromal and vascular alterations within cranial dura mater

et al. 2023

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The cornea and cranial dura mater share sensory innervation. This link raises the possibility that pathological impulses mediated by corneal injury may be transmitted to the cranial dura, trigger dural perivascular/connective tissue nociceptor responses, and induce vascular and stromal alterations affecting dura mater blood and lymphatic vessel functionality. In this study, using a mouse model, we demonstrate for the first time that two weeks after the initial insult, alkaline injury to the cornea leads to remote pathological changes within the coronal suture area of the dura mater. Specifically, we detected significant pro-fibrotic changes in the dural stroma, as well as vascular remodeling characterized by alterations in vascular smooth muscle cell (VSMC) morphology, reduced blood vessel VSMC coverage, endothelial cell expression of the fibroblast specific protein 1, and significant increase in the number of podoplanin-positive lymphatic sprouts. Intriguingly, the deficiency of a major extracellular matrix component, small leucine-rich proteoglycan decorin, modifies both the direction and the extent of these changes. As the dura mater is the most important route for the brain metabolic clearance, these results are of clinical relevance and provide a much-needed link explaining the association between ophthalmic conditions and the development of neurodegenerative diseases.

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Estrogen-Dependent Changes in Dura Mater Microvasculature Add New Insights to the Pathogenesis of Headache

Cited by 8 publications

References 59 publications

Male and female sex hormones in primary headaches

Male and female sex hormones in primary headaches

Complex Non-sinus-associated Pachymeningeal Lymphatic Structures: Interrelationship With Blood Microvasculature

Corneal injury is associated with stromal and vascular alterations within cranial dura mater

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