Estrogen Deficient Male Mice Develop Compulsive Behavior

Hill, Rachel Anne; McInnes, Kerry J.; Gong, Emily C. H.; Jones, Morris; Simpson, Evan R.; Boon, Wah Chin

doi:10.1016/j.biopsych.2006.01.012

Cited by 92 publications

(73 citation statements)

References 57 publications

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“…This highlights a notable sex dimorphism in the requirement and/or ability of estrogen to maintain specific neuronal populations in different brain regions. Although the underlying mechanisms and the functional consequences of these morphological changes are unknown, sex-and age-specific behavioral deficits have been identified in ArKO mice (van den Buuse et al, 2003;Hill et al, 2007) and support the concept that estrogens play a sexually dimorphic role in the CNS.…”

Section: A Peripheral and Central Sites Of Synthesis Of Estrogens Inmentioning

confidence: 63%

Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines

2010

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Section: A Peripheral and Central Sites Of Synthesis Of Estrogens Inmentioning

confidence: 63%

Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines

2010

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“…Therefore, it can be hypothesized that a sex-specific association between OCD and COMT might be explained by a different regulation of COMT expression and activity through differences in the levels of estrogen. In support of this, estrogen deficient male mice develop compulsive behavior such as excessive grooming and barbering [Hill et al, 2007]. These behaviors were associated with reduced hypothalamic COMT levels [Hill et al, 2007].…”

Section: Discussionmentioning

confidence: 98%

The role of the COMT Val¹⁵⁸Met polymorphism in the phenotypic expression of obsessive‐compulsive disorder

Katerberg

Cath

Denys

et al. 2009

American J of Med Genetics Pt B

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Obsessive-Compulsive Disorder (OCD) is characterized by the presence of obsessions and compulsions, and shows considerable phenotypic variability. Family and twin studies have indicated a genetic component in the etiology of OCD, and the catechol-O-methyl transferase (COMT) gene is an important candidate gene for OCD. This study investigates the influence of the functional COMT Val158Met polymorphism on the phenotypic expression of OCD, using an item-level factor-analytic approach in a large sample. The COMT Val158Met variant was genotyped in 373 patients and 462 controls. It was tested whether there was an association between the COMT Val158Met polymorphism and OCD or dimensional phenotypes such as YBOCS severity score, age of onset of obsessive-compulsive symptoms and six symptom dimensions recently found in a large item-level factor-analytic study [Katerberg et al., submitted]. We further investigated possible sex-specific associations between the COMT Val158Met polymorphism and OCD or dimensional phenotypes. There was a trend for an association of the COMT 158Met allele with OCD in males, and an interaction between the COMT Val158Met genotype and sex on the somatic and sensory phenomena symptom dimension, with females showing lower scores. In conclusion, a dimensional approach seems fruitful in detecting genes of importance for OCD.

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“…Whereas the basis for these gender differences is not clear, some evidence suggests that estrogen may have a role in regulating the expression of COMT (Jiang, Xie, Ramsden, & Ho, 2003;Xie, Ho, & Ramsden, 1999). Consistent with this putative function a recent study demonstrated that deficiency in estrogen was associated with a decrease in protein levels of COMT and that estrogen replacement increases COMT expression in male mice (Hill et al, 2007). Finally, a recent PET study reported greater dopamine release in the striatum in men compared to women in response to amphetamine challenge (Munro et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Differential effects of COMT on gait and executive control in aging

Holtzer

Ozelius

Xue

et al. 2010

Neurobiology of Aging

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Walking speed is associated with attention and executive control processes subserved by the prefrontal cortex. Because polymorphisms in COMT influence these cognitive processes we hypothesized that the same polymorphisms may influence gait velocity. We examined the associations between the Val 158 Met polymorphism in COMT and gait velocity as well as attention and executive function. Participants were 278 non-demented older adults. The results revealed that Met/Val was associated with faster gait velocity. This association can be explained by the putative role of the Val allele in regulating tonic dopamine release in the striatum. In contrast, Met/Met was associated with better attention and executive function. Stratification by gender revealed that the association between COMT genotype and gait was significant only in men. Conversely, the association between COMT genotype and attention and executive function was significant only in women. These findings suggest a differential effect in relating the Val 158 Met polymorphism to gait and to cognitive function while supporting the previously described sexual dimorphism in the phenotypic expressions of COMT.

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Estrogen Deficient Male Mice Develop Compulsive Behavior

Cited by 92 publications

References 57 publications

Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines

Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines

The role of the COMT Val¹⁵⁸Met polymorphism in the phenotypic expression of obsessive‐compulsive disorder

Differential effects of COMT on gait and executive control in aging

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Estrogen Deficient Male Mice Develop Compulsive Behavior

Cited by 92 publications

References 57 publications

Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines

Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines

The role of the COMT Val158Met polymorphism in the phenotypic expression of obsessive‐compulsive disorder

Differential effects of COMT on gait and executive control in aging

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The role of the COMT Val¹⁵⁸Met polymorphism in the phenotypic expression of obsessive‐compulsive disorder