Abstract:Asthma is a chronic inflammation of the airways that exhibits sex differences, affecting mostly boys in childhood and women in adulthood. Alveolar macrophages have emerged as major mediators of allergic lung inflammation. We hypothesized that alveolar macrophages respond to estrogen by enhancing M2 responses and thereby contribute to sex differences in asthma. We found that macrophages from female mice exhibited increased expression of canonical M2 markers like Ym1 and Arg1 in response to IL-4. Signaling throu… Show more
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