Abstract:Asthma is a chronic inflammation of the airways that affects over 300 million people worldwide. Asthma exhibits sex differences, affecting mostly boys in childhood and women in adulthood. Alveolar macrophages have emerged as major mediators of allergic lung inflammation. Macrophages express receptors that recognize and respond to estrogen. We hypothesized that estrogen enhances M2 polarization of alveolar macrophages and thereby contributes to asthma. We found increased expression of the canonical mouse M2 mar… Show more
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