Estrogen-binding properties of rat, mouse and man fetospecific serum proteins. Demonstration by immuno-autoradiographic methods

Role for estradiol in female-typical brain and behavioral sexual differentiation

“…Nunez et al [71] reported a low-binding affinity of human serum for steroid hormones during embryonic and early postnatal development. By contrast, both Uriel et al [101] and Arnon et al [4] showed that human AFP could actually bind estrogens. In either case, human AFP-derived peptides are able to display some anti-estrogenic activity [14,66,102].…”

Brain Aromatization and Its Associated Structures.

“…[27] which circulates at high concentrations during the late prenatal and neonatal periods, and then gradually disappears over the first 2 or 3 postnatal weeks [170][171][172]. Although the FEBP binds much of the estrogen present in the fetal and neonatal circulation, it does not sequester androgen, and therefore testosterone has free access to brain targets.…”

Alpha‐fetoprotein

“…An immunoelectrophoretic precipitate obtained with the serum of a patient with primary liver cancer and an anti-AFP antiserum bound radioactivity when incubated with tritiated estradiol as demonstrated by autoradiography [191]. A minor fraction of human AFP has been found to bind on estradiol-Sepharose columns [9, 1901, and can be eluted from the column using estradiol dissolved in 15% dioxan [ 1901.…”