Estrogen and progesterone receptors

Martin, Mary Beth; Saceda, Miguel; Lindsey, Ralph K.

doi:10.1007/978-1-4615-3940-7_13

Cited by 4 publications

(4 citation statements)

References 70 publications

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“…Initial observations of how sex steroid hormones bind to intracellular proteins (40,60), have led to the current hypothesis of sex steroid action (37,47,110,133,157,159,209) (see Fig. 4).…”

Section: Sex Steroid Hormone Receptorsmentioning

confidence: 99%

Endocrinology of sex steroid hormones and cell dynamics in the periodontium

Mariotti¹,

Mawhinney²

2012

Periodontology 2000

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Numerous scientific studies assert the existence of hormone-sensitive periodontal tissues. Tissue specificity of hormone localization, identification of hormone receptors and the metabolism of hormones are evidence that periodontal tissues are targets for sex steroid hormones. Although the etiologies of periodontal endocrinopathies are diverse, periodontal pathologies are primarily the consequence of the actions and interactions of sex steroid hormones on specific cells found in the periodontium. This review provides a broad overview of steroid hormone physiology, evidence for the periodontium being a target tissue for sex steroid hormones and theories regarding the roles of sex steroid hormones in periodontal pathogenesis. Using this information, a teleological argument for the actions of steroid hormones in the periodontium is assessed.

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“…Initial observations of how sex steroid hormones bind to intracellular proteins (40,60), have led to the current hypothesis of sex steroid action (37,47,110,133,157,159,209) (see Fig. 4).…”

Section: Sex Steroid Hormone Receptorsmentioning

confidence: 99%

Endocrinology of sex steroid hormones and cell dynamics in the periodontium

Mariotti¹,

Mawhinney²

2012

Periodontology 2000

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“…On the other hand, it is known that oestrogen and other steroid hormones play a signifiant role in the aetiology of breast cancer on the basis of results from epidemiological, clinical and in vitro studies (Wittlife, 1984;Henderson et al, 1988;Thompson et al, 1990;Beck and Edwards, 1991;Martin, 1991). Oestrogen is the primary hormonal stimulant for proliferation of breast epithelial cells; proliferatng cells appear to sustain a higher risk of undergoing genetic alterations and malignant transformation.…”

mentioning

confidence: 99%

“…Their status in this respect, i.e. the hormone dependency or independency of the breast tumour, can be monitored by measurement of oestrogen/progesterone receptors (Wittlife, 1984;Beck and Edwards, 1991;Martin, 1991;Horwitz, 1993 September 1989 to December 1993, all 616 patients from whom tumours and their corresponding non-cancerous tissues were available were included in the present study; part of this study has also been described previously (Sato et al, 1990(Sato et al, , 1991 (Feinberg and Vogelstein, 1984). Prehybridisation, hybridisation and autoradiography were carried out as described elsewhere (Sato et al, 1990).…”

mentioning

confidence: 99%

Association of genetic alterations on chromosome 17 and loss of hormone receptors in breast cancer

Ito

Yoshimoto²,

Iwase³

et al. 1995

Br J Cancer

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“…Two forms of human ER gene have been identified; ERα (Walter et al, 1985[ 39 ]), which was the first to be recognized, and ERβ (Mosselman et al, 1996[ 29 ]). The ERs are expressed in 60-70 % of BCs (Lim et al, 2012[ 25 ]) and ERα seems to be the predominant form (Martin et al, 1991[ 28 ]); therefore, targeting of ER is a suitable strategy for management of ER-positive BCs, and antiestrogens like tamoxifen which are used for BC therapy act through ER targeting. Although most ER-positive BCs initially respond to tamoxifen therapy, tamoxifen-resistant tumors eventually develop (Johnston, 1997[ 18 ]).…”

Section: Introductionmentioning

confidence: 99%