Estrogen and progesterone receptor isoforms expression in the stomach of Mongolian gerbils

Saqui‐Salces, Milena; Neri-Gómez, Teresa; Gamboa‐Domínguez, Armando; Ruíz-Palacios, Guillermo M.

doi:10.3748/wjg.14.5701

Cited by 15 publications

(11 citation statements)

References 36 publications

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“…This result is similar to that reported for rats [3,8]. Also, the finding that the expected ERβ PCR product was not satisfactorily generated from reverse transcribed mRNA from the uterus of the Mongolian gerbil is consistent with other work [32]. The low level of ERβ expression in the uterus relative to that of ERα may be due to ERβ not being the dominant ER subtype and therefore not playing significant roles in the uterus.…”

Section: Discussionsupporting

confidence: 81%

Effects of Levonorgestrel on Reproductive Hormone Levels and Their Receptor Expression in Mongolian Gerbils (Meriones unguiculatus)

Shi

2011

Exp. Anim.

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Abstract:The effects of levonorgestrel (LNG) on serum levels of reproductive hormones and their receptor mRNA expression in the ovary and uterus of Mongolian gerbils were examined. The results show that serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) increased, whereas serum estradiol (E2) and progesterone (P4) decreased profoundly after LNG treatment. LNG down-regulated the mRNA expression of folliclestimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), estrogen receptor (ER) β and progesterone receptor (PR) in the ovary, and ERα and PR in the uterus of Mongolian gerbils. The down-regulated effects were time-dependent and dose-dependent. LNG had no obvious effects on ERα mRNA expression in the ovary. The findings suggest that LNG impairs reproductive hormone receptor expression at the molecular level in Mongolian gerbils. Also, the two ER subtypes may play different roles in the ovary, and ERβ may not be the predominant ER subtype in the uterus of Mongolian gerbils. The ovary and uterus may be the important sites of action of LNG through its direct progesterone-like effects in Mongolian gerbils.

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Section: Discussionsupporting

confidence: 81%

Effects of Levonorgestrel on Reproductive Hormone Levels and Their Receptor Expression in Mongolian Gerbils (Meriones unguiculatus)

Shi

2011

Exp. Anim.

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“…MNNG-induced gastric cancers in rats have been described to occur more fre- quently in males than in females (Furukawa et al, 1982), and this also suggested that estrogen may play a suppressive role in gastric carcinogenesis (Campbell-Thompson et al, 1999;Furukawa et al, 1982). Estrogen and ER signaling pathways are implicated to play important roles in several physiologic and pathologic outcomes, especially cell growth and transformation (Brandenberger et al, 1997;Enmark et al, 1997;Furukawa et al, 1982;Muramatsu and Inoue, 2000;Saqui-Salces et al, 2008). Cyclin D1/cdk4 are important target genes through which ERα appears to play a key role in estrogen-provoked cellular proliferation, whereas ERβ inhibits transcription of cyclin D1/cdk4 genes and blocks ERα-mediated induction (Liu et al, 2002;Nair et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Cyclin D1/cdk4, estrogen receptors .ALPHA. and .BETA., in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric carcinogenesis: immunohistochemical study

Motohashi

Wakui

Muto³

et al. 2011

J. Toxicol. Sci.

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“…The two PGR isoforms, PGR-A and PGR-B, have different transcriptional activities [Giangrande et al, 2000], due to the presence of an additional activation function domain, AF3, on the longer PGR-B isoform [Saqui-Salces et al, 2008; Schrader and O'Malley, 1972]. Aside from this, both isoforms comprise identical ligand binding and DNA-binding domains [Gellersen et al, 2009; Hager et al, 2000; Mulac-Jericevic and Conneely, 2004].…”

Section: Pgr Regulation Of Transcription In Granulosa Cellsmentioning

confidence: 99%

Control of oocyte release by progesterone receptor-regulated gene expression

2009

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The progesterone receptor (PGR) is a nuclear receptor transcription factor that is essential for female fertility, in part due to its control of oocyte release from the ovary, or ovulation. In all mammals studied to date, ovarian expression of PGR is restricted primarily to granulosa cells of follicles destined to ovulate. Granulosa cell expression of PGR is induced by the pituitary Luteinizing Hormone (LH) surge via mechanisms that are not entirely understood, but which involve activation of Protein Kinase A and modification of Sp1/Sp3 transcription factors on the PGR promoter. Null mutations for PGR or treatment with PGR antagonists block ovulation in all species analyzed, including humans. The cellular mechanisms by which PGR regulates ovulation are currently under investigation, with several downstream pathways having been identified as PGR-regulated and potentially involved in follicular rupture. Interestingly, none of these PGR-regulated genes has been demonstrated to be a direct transcriptional target of PGR. Rather, in ovarian granulosa cells, PGR may act as an inducible coregulator for constitutively bound Sp1/Sp3 transcription factors, which are key regulators for a discrete cohort of ovulatory genes.

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Estrogen and progesterone receptor isoforms expression in the stomach of Mongolian gerbils

Abstract: The presence of ER-alpha and PR isoforms in gerbils stomach suggests that E2 and P4 actions in this organ are in part mediated by their nuclear receptors.

Cited by 15 publications

References 36 publications

Effects of Levonorgestrel on Reproductive Hormone Levels and Their Receptor Expression in Mongolian Gerbils (Meriones unguiculatus)

Effects of Levonorgestrel on Reproductive Hormone Levels and Their Receptor Expression in Mongolian Gerbils (Meriones unguiculatus)

Cyclin D1/cdk4, estrogen receptors .ALPHA. and .BETA., in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric carcinogenesis: immunohistochemical study

Control of oocyte release by progesterone receptor-regulated gene expression

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