Estrogen and progesterone receptor isoform distribution through the menstrual cycle in uteri with and without adenomyosis

Mehasseb, Mohamed K.; Panchal, Rina; Taylor, Anthony H.; Brown, Laurence; Bell, Steven; Habiba, Marwan

doi:10.1016/j.fertnstert.2011.02.051

Cited by 122 publications

(100 citation statements)

References 56 publications

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“…PIK3-AKT-mTOR and the CTNNB1 signalling pathways have been linked to endometrioid cancer [5, 6], and genetic and epigenetic alterations affecting these pathways have also been shown in adenomyosis [3, 117]. But while genetic and epigenetic studies have suggested convergence in the mechanisms involved in cancer and adenomyosis, the infrequent occurrence of cancer in adenomyosis may be related to the similarities between adenomyosis and to the basal layer in the endometrium, which is less responsive to steroids [118]. …”

Section: Resultsmentioning

confidence: 99%

Adenomyosis and Endometrial Cancer: Literature Review

Habiba

Pluchino

Petignat

et al. 2018

Gynecol Obstet Invest

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To confirm the origin of cancer found in both the endometrium and the myometrium is difficult. Cancer may spread from the endometrium into adenomyotic foci or vice versa. Also, premalignant changes may arise at either or both sites. Investigating disease origin enhances our understanding of pathophysiology and prognosis. Additional critical questions are whether women with adenomyosis have a higher risk of endometrial cancer; whether the invasive properties and prognosis of cancer in adenomyosis differ from those arising in the eutopic endometrium and whether the ectopic glandular tissue in adenomyosis becomes altered in the presence of eutopic endometrial cancer. A final question is whether cancer arising within adenomyosis carries a worse prognosis because of its location within the myometrium and the possibility that the presence of adenomyosis facilitates invasion of cancer arising in the eutopic endometrium. The present review explores currently available literature in an attempt to answer these questions and to examine clinical presentations, diagnostic criteria, pathogenesis and prognosis.

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Section: Resultsmentioning

confidence: 99%

Adenomyosis and Endometrial Cancer: Literature Review

Habiba

Pluchino

Petignat

et al. 2018

Gynecol Obstet Invest

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“…On the contrary, Mehasseb et al (19) suggested that estrogen receptor-β expression and the lack of progesterone receptor expression were related to the development and/or progression of adenomyosis and might explain the poor response of adenomyosis-associated menstrual symptoms to progestational agents. These findings suggest that estrogen receptor plays an important role in the pathogenesis of endometriosis and adenomyosis.…”

Section: Discussionmentioning

confidence: 99%

Sequential Observation of Implanted Endometriosis by Laparoscopy in Rats: Correlation Between the Prevalence Rate and the Estrous Cycle

Uchida

Kobayashi

2013

J Pharmacol Sci

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Abstract. This study aimed to clarify the correlation between the estrous cycle and prevalence rate of endometriosis by sequential laparoscopy in Wistar-Imamichi female rats. The peritoneal implantation of endometrial tissue was performed in four estrous cycle rats (proestrus, estrus, metestrus, and diestrus). One week after implantation, the volume of the ectopic endometriosis was measured, and sequential laparoscopy was performed for 4 weeks to observe the prevalence rate. Five weeks after implantation, the volume of the ectopic endometriosis was measured again after laparoscopy. One week after implantation, the volume of endometriosis was significantly larger in proestrus and estrus rats than metestrus and diestrus rats. Prevalence rate was decreased with time. Five weeks after implantation, the prevalence rate and volume were higher and larger in the metestrus, diestrus, and estrus rats than in the proestrus rats. These results show that the estrous cycle affects the change of ectopic endometriosis. The decrease of prevalence rate was slow in metestrus, diestrus, and estrus rats as compared to that in proestrus rats. The volume of ectopic endometriosis showed little decrease with time when the endometrial tissue was implanted during the metestrus and diestrus portion of the cycle. Moreover, sequential laparoscopy made it possible to observe the prevalence rate of endometriosis.

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“…На сегодняшний день не вызывает сомне-ний роль гиперэстрогенемии в развитии эндо-метриоза, которая в свою очередь стимулирует пролиферативный процесс в эндометриоидных гетеротопиях на фоне измененного рецептор-ного статуса эндометрия [12][13][14][15]. По мнению M. Karita и др.…”

Section: Discussionunclassified

The features of the expression of sex steroids hormone receptors, pro-inflammatory markers and cyclin-dependent kinase inhibitor protein p16ink4a in endometrium at external genital endometriosis

et al. 2016

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Background. A local inflammatory reaction in the endometrium caused by viral infection and associated with external genital endometriosis (EGE) can affect the implantation properties of endometrium and be one of the causes of infertility. The aim of the study was to investigate the expression of estrogen and progesterone receptors, pro-inflammatory markers and inhibitor of cyclin-dependent kinases p16ink4a in the endometrium of women with infertility associated with EGE. Materials and methods. The object of the study was the material taken from 133 patients aged 19-35 years. Inclusion criteria were the presence of external genital endometriosis confirmed by laparoscopy and the absence of hormone treatment for 6 months prior to this study. Endometrial biopsies were obtained on 19-24 day of the menstrual cycle. Histological and immunohistochemical studies of endometrial biopsies were performed using standard methods. The expression of estrogen (ER) and progesterone receptors (PgR), inflammatory markers (CD8+, CD20+, CD4+, CD138+) and inhibitor of cyclin-dependent kinase p16ink4a were examined by immunohistochemistry. The evaluation of the expression of studied markers was performed in the epithelium of the glands and endometrial stromal component separately, using semiquantitative method H-Score, as well as qualitative and quantitative methods in image analysis system “Morphology 5.0” (VideoTest, Russia). Statistical analysis was performed using statistical software (STATGRAPHICS v.6.0). Results. A significant decrease in the expression of ER and PgR in endometrial stromal component was noted on the background of the high incidence of chronic endometritis in patients with EGE. All patients of the main group had a positive expression of p16ink4a. Conclusions. The obtained results indicate a high incidence of disorders of eutopic endometrial secretory transformation in patients with infertility associated with external genital endometriosis. The high incidence of the virus associated with chronic endometritis and sensitivity violation of endometrial tissue to sex steroid hormones, such as progesterone, may be a major determinant of infertility of patients in this group.

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Estrogen and progesterone receptor isoform distribution through the menstrual cycle in uteri with and without adenomyosis

Cited by 122 publications

References 56 publications

Adenomyosis and Endometrial Cancer: Literature Review

Adenomyosis and Endometrial Cancer: Literature Review

Sequential Observation of Implanted Endometriosis by Laparoscopy in Rats: Correlation Between the Prevalence Rate and the Estrous Cycle

The features of the expression of sex steroids hormone receptors, pro-inflammatory markers and cyclin-dependent kinase inhibitor protein p16ink4a in endometrium at external genital endometriosis

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