Estrogen and Microbiota Crosstalk: Should We Pay Attention?

Chen, Karen L.; Madak-Erdoğan, Zeynep

doi:10.1016/j.tem.2016.08.001

Cited by 134 publications

(83 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Yerkovetskiy et al demonstrated that microbes are able to regulate sex hormone levels and that sex hormones could change the microbial composition of the gut (Yurkovetskiy et al, 2013). It was also suggested that estrogen-like compounds may be metabolized by gut microbes to produce estrogenic metabolites that could affect the immune system (Chen and Madak-Erdogan, 2016). High fat diets were shown to increase the lipopolysaccharide (LPS) producing Gram-negative bacteria, whereas estrogen was reported to reduce LPS-induced inflammation and decrease the concentration of these bacteria (Blasco-Baque et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells

Benedek

Zhang

Nguyen

et al. 2017

Journal of Neuroimmunology

View full text Add to dashboard Cite

Sex hormones promote immunoregulatory effects on multiple sclerosis. In the current study we evaluated the composition of the gut microbiota and the mucosal-associated regulatory cells in estrogen or sham treated female mice before and after autoimmune encephalomyelitis (EAE) induction. Treatment with pregnancy levels of estrogen induces changes in the composition and diversity of gut microbiota. Additionally, estrogen prevents EAE-associated changes in the gut microbiota and might promote the enrichment of bacteria that are associated with immune regulation. Our results point to a possible cross-talk between the sex hormones and the gut microbiota which could promote neuroprotection.

show abstract

Section: Discussionmentioning

confidence: 99%

Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells

Benedek

Zhang

Nguyen

et al. 2017

Journal of Neuroimmunology

View full text Add to dashboard Cite

show abstract

“…Numerous factors affect the bioavailability of ingested dietary ingredients. Estrogen deficiency also results in various environmental change such as alteration of gut microbiota and OVX can affect the bioavailability of functional ingredients owing to intestinal microbial changes as well; changes in the intestinal microbial environment in turn will affect the metabolism and absorption of dietary ingredients. Our results showed that bioavailability of isoflavone metabolites differed significantly between sham and OVX groups even when administered the same sample, suggesting that OVX affects the bioavailability of isoflavones.…”

Section: Discussionmentioning

confidence: 99%

Nutrikinetics of Isoflavone Metabolites After Fermented Soybean Product (Cheonggukjang) Ingestion in Ovariectomized Mice

Lee

Kim

Ahn

et al. 2017

Molecular Nutrition Food Res

View full text Add to dashboard Cite

ScopeCheonggukjang (CGJ) is a soybean‐based quick‐fermented food popular in Korea that contains a variety of biologically active compounds including isoflavones and saponins. Isoflavone bioavailability may be important for the bone health of postmenopausal women; therefore, the aim of this study is to evaluate the influence of fermentation on the isoflavone metabolite nutrikinetic profile after single dose CGJ or unfermented soybean administration in ovariectomized (OVX) and sham mice.Methods and resultsWe identify 34 isoflavone metabolites using UPLC–QTOF‐MS and analyze their nutrikinetics at different time points (0.25, 0.5, 1, 2, 4, 8, 16, and 24 h) to understand their fermentation‐ and OVX‐mediated time‐dependent concentration changes. Nutrikinetics analysis shows that genistein, daidzein, genistein 4′‐sulfate, dihydrodaidzein sulfate, equol 4′‐sulfate, and equol‐7‐glucuronide are present at high concentrations in all groups based on area‐under‐the‐curve analysis. OVX mice appear to show lower isoflavone bioavailability than mice in the sham group. CGJ enhances various isoflavone metabolite bioavailability including genistein, 3‐hydroxygenistein, and equol 7‐glucuronide, compared to the unfermented soybean‐treated group. Among these metabolites, intact isoflavones, 3‐hydroxygenistein, genistein 4′‐sulfate, and equol 7‐glucuronide promote osteoblastogenesis and inhibit osteoclast formation.ConclusionsCGJ has good isoflavone bioavailability and may be beneficial for the bone health of postmenopausal women.

show abstract

“…133 On the other hand, estrogens are metabolized by microbes secreting b-glucuronidase, an enzyme that deconjugates estrogen, allowing the 'active' metabolite to enter the bloodstream and bind to estrogen receptors. 134 Treatment with pregnancy levels of estrogen induces changes in the composition and diversity of the gut microbiota, associated with protection against EAE. 135 It was shown that while EAE led to dysbiosis in mice, pretreatment with estrogen reduced these changes and increased regulatory B-cell and anti-inflammatory macrophage numbers in mesenteric lymph nodes and in the spinal cord.…”

Section: Interaction Between Hormonal and Environmental Factorsmentioning

confidence: 99%

Impact of sex hormones on immune function and multiple sclerosis development

2018

View full text Add to dashboard Cite

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) affecting young people and leading to demyelination and neurodegeneration. The disease is clearly more common in women, in whom incidence has been rising. Gender differences include: earlier disease onset and more frequent relapses in women; and faster progression and worse outcomes in men. Hormone-related physiological conditions in women such as puberty, pregnancy, puerperium, and menopause also exert significant influence both on disease prevalence as well as on outcomes. Hormonal and/or genetic factors are therefore believed to be involved in regulating the course of disease. In this review, we discuss clinical evidence for the impact of sex hormones (estrogens, progesterone, prolactin, and testosterone) on MS and attempt to elucidate the hormonal and immunological mechanisms potentially underlying these changes. We also review current knowledge on the relationship between sex hormones and resident CNS cells and provide new insights in the context of MS. Understanding these molecular mechanisms may contribute to the development of new and safer treatments for both men and women.

show abstract

Estrogen and Microbiota Crosstalk: Should We Pay Attention?

Cited by 134 publications

References 14 publications

Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells

Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells

Nutrikinetics of Isoflavone Metabolites After Fermented Soybean Product (Cheonggukjang) Ingestion in Ovariectomized Mice

Impact of sex hormones on immune function and multiple sclerosis development

Contact Info

Product

Resources

About