Estrogen and androgen regulate actin-remodeling and endocytosis-related genes during rat spermiation

Kumar, Anita; Dumasia, Kushaan; Gaonkar, Reshma; Sonawane, Shobha; Kadam, Leena; Balasinor, Nafisa

doi:10.1016/j.mce.2014.12.029

Cited by 25 publications

(16 citation statements)

References 37 publications

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“…On the other hand, over-activation of ERβ did not lead to changes in the gonadotropin level, but caused spermatocytes’ apoptosis (intrinsic pathway—via mitochondria) and spermiation failure as a result of the disruption of tubulobulbar complexes (TBCs) [130,157]. This observation is in agreement with previous studies where a high intratesticular level of oestrogens affected formation of TBCs [158] due to deregulation of actin-remodelling transcripts [102]. Apical TBCs are actin-based structures on the concave surface of the spermatid head, where a close contact between Sertoli cells and elongated spermatids is formed and spermatids are prepared for release into the tubular lumen [159].…”

Section: The Effect Of Oestrogens On Spermatogenesis and Spermsupporting

confidence: 88%

“…In contrast, the recruitment of ERβ and its co-activator Src1 (steroid receptor co-activator 1) is decreased in Evl (Ena-vasodilator stimulated phosphoprotein) ERE after E2 treatment, thus causing downregulation of Evl [101]. Both, Arpc1b and Evl are involved in actin remodelling during spermiation, and they are responsive to E2 but not to dihydrotestosterone [102]. Src1, Src2 (also named TIF2, GRIP1), and Src3 (also named p/CIP, RAC3, ACTR, AIB1) belong to the p160 family of nuclear receptor co-activators.…”

Section: Oestrogen Receptorsmentioning

confidence: 99%

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Of Oestrogens and Sperm: A Review of the Roles of Oestrogens and Oestrogen Receptors in Male Reproduction

Dostalova

Žatecká

Dvořáková-Hortová

2017

IJMS

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The crucial role that oestrogens play in male reproduction has been generally accepted; however, the exact mechanism of their action is not entirely clear and there is still much more to be clarified. The oestrogen response is mediated through oestrogen receptors, as well as classical oestrogen receptors’ variants, and their specific co-expression plays a critical role. The importance of oestrogen signalling in male fertility is indicated by the adverse effects of selected oestrogen-like compounds, and their interaction with oestrogen receptors was proven to cause pathologies. The aims of this review are to summarise the current knowledge on oestrogen signalling during spermatogenesis and sperm maturation and discuss the available information on oestrogen receptors and their splice variants. An overview is given of species-specific differences including in humans, along with a detailed summary of the methodology outcome, including all the genetically manipulated models available to date. This review provides coherent information on the recently discovered mechanisms of oestrogens’ and oestrogen receptors’ effects and action in both testicular somatic and germ cells, as well as in mature sperm, available for mammals, including humans.

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Section: The Effect Of Oestrogens On Spermatogenesis and Spermsupporting

confidence: 88%

Section: Oestrogen Receptorsmentioning

confidence: 99%

Of Oestrogens and Sperm: A Review of the Roles of Oestrogens and Oestrogen Receptors in Male Reproduction

Dostalova

Žatecká

Dvořáková-Hortová

2017

IJMS

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“…This indicates that E 2 through ERb, along with testosterone, plays an important role in the process of spermiation and activation of E 2 signaling through ERb alone can cause retention of mature spermatids. The results of parallel investigations in our lab have also indicated that cytoskeletal genes regulated by ERb are involved in spermiation and their downregulation leads to failure of spermiation (Kumar et al 2015).…”

Section: Discussionmentioning

confidence: 67%

Effect of estrogen receptor-subtype-specific ligands on fertility in adult male rats

Dumasia

Kumar

Kadam

et al. 2015

Journal of Endocrinology

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Maintenance of normal male fertility relies on the process of spermatogenesis which is under complex endocrine control by mechanisms involving gonadotropin and steroid hormones. Although testosterone is the primary sex steroid in males, estrogen is locally produced in the testis and plays a very crucial role in male fertility. This is evident from presence of both the estrogen receptors alpha (ERa) and beta (ERb) in the testis and their absence, as in the case of knockout mice models, leads to sterility. The present study was undertaken to understand individual roles of the two ERs in spermatogenesis and their direct contribution towards the maintenance of male fertility using receptor-subtype-specific ligands. Administration of ERa and b agonists to adult male rats for 60 days results in a significant decrease in fertility, mainly due to an increase in pre-and post-implantation loss and a concomitant decrease in litter size and sperm counts. Our results indicate that ERa is mainly involved in negative feedback regulation of gonadotropin hormones, whereas both ERs are involved in regulation of prolactin and testosterone production. Histological examinations of the testis reveal that ERb could be involved in the process of spermiation since many failed spermatids were observed in stages IX-XI following ERb agonist treatment. Our results indicate that overactivation of estrogen signaling through either of its receptors can have detrimental effects on the fertility parameters and that the two ERs have both overlapping and distinct roles in maintenance of male fertility.

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“…Recent studies have revealed subtype-specific roles of ERs during spermatogenesis: ERα in spermatid differentiation and ERβ in germ cell apoptosis and sperm release [73,74]. In the epididymis, E2 regulates contractility and speeds up sperm transit time [75].…”

Section: Physiological Functionsmentioning

confidence: 99%

Estradiol: A Steroid with Multiple Facets

et al. 2018

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Seventy-five glorious years have passed since estradiol was discovered by Edward Doisy. From discovery in the ovaries to delineation of diverse physiological effects, research on estrogens has covered a lot of ground. Estrogen receptors that mediate estrogenic effects, have been detected not only in reproductive organs, but also in other body organs. Estrogen receptors function either as conventional transcription factors or as rapid signal transducers. These different modes of action are opted by estrogens to elicit an array of reproductive and non-reproductive functions. It is well established that estrogens promote cell proliferation in various tissues and hence are also linked to carcinogenesis. Anti-estrogens are being used as adjunct therapies for cancers since several years. On the other hand, estrogen-based strategies are used to alleviate adverse effects of menopause. Apart from estrogens synthesized in various organs, exposure to environmental estrogens can also impact physiology. Thus, too much or too less of estrogens can tip the balance and lead to unfavorable consequences. Multiple estrogen receptors with their tissue- or cell type-specific expression eliciting dose-dependent effects make it perplexing to 'unify' estrogenic actions in diverse tissues/organs. This warrants more research on estrogen-mediated effects and their regulation in somatic and reproductive tissues. This review presents physiological and pathological aspects of estrogens thus highlighting the good, bad, and ugly facets of estrogens.

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Estrogen and androgen regulate actin-remodeling and endocytosis-related genes during rat spermiation

Cited by 25 publications

References 37 publications

Of Oestrogens and Sperm: A Review of the Roles of Oestrogens and Oestrogen Receptors in Male Reproduction

Of Oestrogens and Sperm: A Review of the Roles of Oestrogens and Oestrogen Receptors in Male Reproduction

Effect of estrogen receptor-subtype-specific ligands on fertility in adult male rats

Estradiol: A Steroid with Multiple Facets

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