Estrin Excretion in Psychotic Patients

Lansbury, John; Hughes, Joseph

doi:10.1176/ajp.95.5.1119

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…Allen and Henry state, 'Such observations are of special interest in that they evoke questions regarding the source and nature of psychotic disorders'. Lansbury and Hughes (1939) quoted several papers written between 1930 and 1938 all dealing with the fact that estrin levels (ovarian hormones) in psychotic women were variable and that is associated with the schizophrenia. These authors have all used different methodology to establish estrin levels in women with schizophrenia and other severe mental illnesses.…”

Section: Menstrual Abnormalities In Schizophrenia Before the Introducmentioning

confidence: 99%

“…They were trying to understand the abnormality and were aware that menstrual changes in psychotic women needed further explanation (see Jansen et al, 1936;Kafka, 1935;Smith and Smith, 1935;Smith et al, 1937). Lansbury and Hughes (1939) further stated that 'the phenomenon of amenorrhoea which is commonly encountered during the courses of these states, naturally points to the possibility of some disturbances in the production or secretion of the ovarian hormone (estrin)'. They measured estrin levels with somewhat unconventional methods and stated that they found normal levels of this hormone, although menstrual irregularities and amenorrhoea continued to feature clinically.…”

Section: Menstrual Abnormalities In Schizophrenia Before the Introducmentioning

confidence: 99%

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The evolution of hyperprolactinaemia as an entity in psychiatric patients

Kohen¹,

Wildgust²

2008

J Psychopharmacol

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This paper explores chronologically the evolution of raised prolactin levels as an entity in psychiatric patients. Menstrual problems were described in patients with schizophrenia prior to the introduction of antipsychotic medication, but galactorrhoea and gynaecomastia were not commonly seen until the advent of antipsychotics. Following the introduction of antipsychotic medication single case reports of patients with galactorrhoea and gynaecomastia appeared. These were followed by a collection of case reports and the process reached today's data of laboratory defined rates of prolactin and sexual side effects. The paper also reviews the emerging research linking hyperprolactinaemia with increased risk of osteoporosis and possibly breast cancer. An overarching thread which runs throughout these publications, is the paucity of clinical research, which has only recently begun to be addressed.

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Section: Menstrual Abnormalities In Schizophrenia Before the Introducmentioning

confidence: 99%

Section: Menstrual Abnormalities In Schizophrenia Before the Introducmentioning

confidence: 99%

The evolution of hyperprolactinaemia as an entity in psychiatric patients

Kohen¹,

Wildgust²

2008

J Psychopharmacol

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Hypoestrogenism and Estrogen Replacement Therapy in Women Suffering from Schizophrenia

Bergemann¹,

Mundt²,

Parzer³

et al.

Estrogen Effects in Psychiatric Disorders

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Acute psychiatric admission and menstrual cycle phase in women with schizophrenia

Bergemann¹,

Parzer²,

Nagl³

et al. 2002

Archives of Women's Mental Health

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The clinical observation of a possible relation between the phases of the menstrual cycle and psychotic illness dates well back to the beginning of the nineteenth century. This relation is considered to provide further evidence for the protective effect of oestrogens in schizophrenic women and is summarised by the so-called oestrogen hypothesis. In addition, the hypoestrogenism hypothesis postulates a hypofunction of the gonads in women with schizophrenia with subsequent oestrogen deficiency syndrome. The aim of the present clinical study was to answer the question whether there is a perimenstrual increase in hospital admissions of women suffering from an exacerbation of schizophrenia. Two samples of premenopausal women with schizophrenia were investigated (sample 1: n = 115; sample 2: n = 170). In both samples there was a significant increase in admissions in the perimenstrual phase - three days before and three days after the first day of the menses (sample 1: P = 0.002, sample 2: P = 0.028, binomial test). 37.4% of the patients were admitted during the perimenstrual phase of the cycle in sample 1, 31.8% in sample 2. Regarding age, age at onset, and duration of illness, no difference was found between the group admitted to hospital during the perimenstrual phase versus the group admitted during the rest of the menstrual cycle in either of the samples. The results are discussed in relation to the possibly underlying physiological mechanisms.

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Estrin Excretion in Psychotic Patients

Cited by 3 publications

References 3 publications

The evolution of hyperprolactinaemia as an entity in psychiatric patients

The evolution of hyperprolactinaemia as an entity in psychiatric patients

Hypoestrogenism and Estrogen Replacement Therapy in Women Suffering from Schizophrenia

Acute psychiatric admission and menstrual cycle phase in women with schizophrenia

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