Estrategias de curación de la infección por VIH

Rodríguez-Muñoz, Jesús; Moreno, Santiago

doi:10.1016/j.eimc.2018.01.007

Cited by 4 publications

(2 citation statements)

References 56 publications

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“…Following the exposure to both 3TC and AZT, we observed substantially lower concentrations of FABP4 compared to the control cells. FABP4 is known to play a role in inhibiting lipogenesis while promoting lipolysis, thereby influencing the composition of circulating free fatty acids [32]. Additionally, it significantly contributes to the promotion of lipotoxicity, mainly by triggering endoplasmic reticulum stress and oxidative stress through its actions on the mitochondria, leading to reactive oxygen species production and subsequent inflammation.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Nucleoside Reverse Transcriptase Inhibitors on Mitochondrial Activity, Lipid Content, and Fatty-Acid-Binding Protein Levels in Microglial HMC3 Cells

Lipke,

Kubis-Kubiak,

Piwowar

2023

Pharmaceuticals

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Despite the availability of a wide range of preventive measures and comprehensive treatment options following infection, the development of acquired immunodeficiency syndrome (AIDS) remains a persistent challenge. Nucleoside reverse transcriptase inhibitors (NRTIs) represent the most commonly utilized therapeutic approach, despite being on the pharmaceutical market for nearly four decades. During this time, a spectrum of side effects ranging from mild discomfort and hypersensitivity reactions to the more prevalent nephrotoxicity and hepatotoxicity has been documented. In light of these considerations, our study aimed to investigate the impacts of two NRTIs, lamivudine and zidovudine, on lipid metabolism in HMC3 microglial cells. Our findings revealed statistically significant reductions in the ATP levels (nearly 8%) and increased mitochondrial superoxide levels (around 10%) after 24 h of treatment with the maximum therapeutic concentration of zidovudine compared to the untreated microglial cells. Furthermore, the concentrations of fatty-acid-binding proteins 4 and 5 were significantly lower (approximately 40%) in the microglial cells that were exposed to NRTIs than in the untreated cells. Notably, the total lipid concentration within the microglial cells markedly increased following NRTI administration with a 13% rise after treatment with 10 µM lamivudine and a remarkable 70% surge following the administration of 6 µM zidovudine. These results suggest that the prolonged administration of NRTIs may potentially lead to lipid accumulation, posing a significant risk to the delicate homeostasis of the neuronal system and potentially triggering a pro-inflammatory response in microglial cells.

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Section: Discussionmentioning

confidence: 99%

The Influence of Nucleoside Reverse Transcriptase Inhibitors on Mitochondrial Activity, Lipid Content, and Fatty-Acid-Binding Protein Levels in Microglial HMC3 Cells

Lipke,

Kubis-Kubiak,

Piwowar

2023

Pharmaceuticals

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“…As we all know, viral infections are the main reasons for human death worldwide [ 1 ]. Several infectious viral diseases occurred so far have been reported, which involve viruses such as influenza [ 2 ], Herpes Simplex Virus (HSV) [ 3 ], Human Immunodeficiency Virus (HIV) [ 4 ], Respiratory Syncytial Virus (RSV) [ 5 ], Enterovirus 71 (EV71) [ 6 ], Dengue Virus (DENV) [ 7 ], Ebola Virus [ 8 ], as well as the recently emerging coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [ 9 ]. The main characteristic of viruses is that their genomes are easily mutated, making it difficult to control viral infections and causing pandemics worldwide.…”

Section: Introductionmentioning

confidence: 99%

Antiviral potential of natural products from marine microbes

Lin

Zhang

et al. 2020

European Journal of Medicinal Chemistry

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Humans have been suffered from viral infections over the centuries, such as influenza, HSV, and HIV, which have killed millions of people worldwide. However, the availability of effective treatments for infectious diseases remains limited until now, as most of the viral pathogens resisted to many medical treatments. Marine microbes are currently one of the most copious sources of pharmacologically active natural products, which have constantly provided promising antivirus agents. To date, a large number of marine microbial secondary metabolites with antiviral activities have been widely reported. In this review, we have summarized the potential antivirus compounds from marine microorganisms over the last decade. In addition, the structures, bioactivities, and origins of these compounds were discussed as well.

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Trimethylene Methane Dianion Equivalent for the Asymmetric Consecutive Allylation of Aldehydes: Applications to Prins-Driven Macrocyclizations for the Synthesis of Bryostatin 1 and Analogues

et al. 2022

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We report a one-step (one-flask) generation and reaction of a bifunctional allylating reagent, a trimethylene methane dianion equivalent, that provides a route for the asymmetric 2-(trimethylsilylmethyl) allylation of aldehydes. The product of the first aldehyde allylation process is then set to engage in a second separate aldehyde allylation, providing an improved Prins macrocyclization strategy both for the scalable synthesis of bryostatin 1 and for the total synthesis of a new potent bryostatin analogue.

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Estrategias de curación de la infección por VIH

Cited by 4 publications

References 56 publications

The Influence of Nucleoside Reverse Transcriptase Inhibitors on Mitochondrial Activity, Lipid Content, and Fatty-Acid-Binding Protein Levels in Microglial HMC3 Cells

The Influence of Nucleoside Reverse Transcriptase Inhibitors on Mitochondrial Activity, Lipid Content, and Fatty-Acid-Binding Protein Levels in Microglial HMC3 Cells

Antiviral potential of natural products from marine microbes

Trimethylene Methane Dianion Equivalent for the Asymmetric Consecutive Allylation of Aldehydes: Applications to Prins-Driven Macrocyclizations for the Synthesis of Bryostatin 1 and Analogues

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