Estradiol Values During Embryo Transfer and Clinical Outcomes of Letrozole Cycles

Abstract

alized window of implantation (WOI). This study aims to closely examine the characteristics of patients who underwent an ERA and compare success rates of patients who transferred a PGT-A euploid embryo with an adjusted WOI and with a standard WOI.MATERIALS AND METHODS: Patients who underwent an ERA at a private fertility clinic in NYC during 2019 and 2020 were included. The outcome of the first programmed FET cycle following the ERA with PGT-A euploid embryo(s) was evaluated for patients with Receptive ERA vs. those with an adjusted WOI due to a non-receptive ERA. Exclusion criteria were untested embryos and natural FET cycles.Continuous variables were measured as mean and standard deviation and compared with a two-sample t-test. Categorical variables were compared with a Fisher test. A p-value of <0.05 was considered statistically significant.RESULTS: A total of 46 PGT-A euploid transfers following an ERA were included. Out of the 46 patients, 23 patients received receptive results, while the other 23 patients were classified as non-receptive (including pre-, early, or post-receptive). The distribution of infertility diagnoses was similar between both groups. A PGT-A euploid FET in the receptive group resulted in a 70% implantation rate and 39% rate of ongoing clinical intrauterine gestation. In the non-receptive group, the rates were respectively 65% and 35% and statistically similar.CONCLUSIONS: Adjusted timing of FET for non-receptive ERA patients produced similar pregnancy rates as patients with a receptive ERA.IMPACT STATEMENT: As the use of ERA tests become more popular, it is important to determine its efficacy and role in routine care. From this retrospective cohort study, the adjusted timing of FET for non-receptive ERA produced similar pregnancy rates as patients with receptive ERA.