Estradiol treatment in a large cohort of younger women with congenital hypogonadism: how much is enough?

Howarth, Sophie; Quinton, Richard; Mohammed, Azmi

doi:10.1111/cen.14845

Cited by 3 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although there is limited evidence assessing the optimal regimen, dose or route of administration of hormone replacement in women with POI, 7 the transgender practice of HRT prescribing can be safely applied to this younger group of women, with due consideration given to appropriate progestogen dosing to protect against endometrial hyperplasia, or with endometrial imaging surveillance with ultrasound in selected cases. 5,8 Since the recent release of the BMS joint statement, we have already encountered a number of clinical queries from colleague in Primary Care raising concerns about HRT regimens in younger patients with POI or central hypogonadism and transgender women patients. This has resulted in an increased and unnecessary administrative burden and is also likely to be resulting in anxiety in these patient groups who may be concerned about ongoing access to their optimal HRT regimens.…”

Section: Dear Editormentioning

confidence: 99%

Risk of suboptimal hormone replacement therapy for young hypogonadal women and transgender women in the wake of the Joint BMS FSRH RCGP RCOG SfE and RCN Women's Health Forum safety alert

Mamoojee

Mitchell

Quinton

2023

Clinical Endocrinology

Self Cite

View full text Add to dashboard Cite

Section: Dear Editormentioning

confidence: 99%

Risk of suboptimal hormone replacement therapy for young hypogonadal women and transgender women in the wake of the Joint BMS FSRH RCGP RCOG SfE and RCN Women's Health Forum safety alert

Mamoojee

Mitchell

Quinton

2023

Clinical Endocrinology

Self Cite

View full text Add to dashboard Cite

Society for endocrinology guideline for understanding, diagnosing and treating female hypogonadism

Jayasena,

Devine,

Barber

et al. 2024

Clinical Endocrinology

View full text Add to dashboard Cite

Female hypogonadism (FH) is a relatively common endocrine disorder in women of premenopausal age, but there are significant uncertainties and wide variation in its management. Most current guidelines are monospecialty and only address premature ovarian insufficiency (POI); some allude to management in very brief and general terms, and most rely upon the extrapolation of evidence from the studies relating to physiological estrogen deficiency in postmenopausal women. The Society for Endocrinology commissioned new guidance to provide all care providers with a multidisciplinary perspective on managing patients with all forms of FH. It has been compiled using expertise from Endocrinology, Primary Care, Gynaecology and Reproductive Health practices, with contributions from expert patients and a patient support group, to help clinicians best manage FH resulting from both POI and hypothalamo‐pituitary disorders, whether organic or functional.

show abstract

Outcomes and experiences of adults with congenital hypogonadism can inform improvements in the management of delayed puberty

Howard,

Quinton

2023

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

Patients with congenital hypogonadism will encounter many health care professionals during their lives managing their health needs; from antenatal and infantile periods, through childhood and adolescence, into adult life and then old age. The pubertal transition from childhood to adult life raises particular challenges for diagnosis, therapy and psychological support, and patients encounter many pitfalls. Many patients with congenital hypogonadism and delayed or absent puberty are only diagnosed and treated after long diagnostic journeys, and their management across different centres and countries is not well standardised. Here we reconsider the management of pubertal delay, whilst addressing problematic diagnostic issues and highlighting the limitations of historic pubertal induction protocols – from the perspective of both an adult and a paediatric endocrinologist, dealing in our everyday work with the long-term adverse consequences to our hypogonadal patients of an incorrect and/or late diagnosis and treatment in childhood.

show abstract

Estradiol treatment in a large cohort of younger women with congenital hypogonadism: how much is enough?

Cited by 3 publications

References 9 publications

Risk of suboptimal hormone replacement therapy for young hypogonadal women and transgender women in the wake of the Joint BMS FSRH RCGP RCOG SfE and RCN Women's Health Forum safety alert

Risk of suboptimal hormone replacement therapy for young hypogonadal women and transgender women in the wake of the Joint BMS FSRH RCGP RCOG SfE and RCN Women's Health Forum safety alert

Society for endocrinology guideline for understanding, diagnosing and treating female hypogonadism

Outcomes and experiences of adults with congenital hypogonadism can inform improvements in the management of delayed puberty

Contact Info

Product

Resources

About