Estradiol, Progesterone and Testosterone Exposures Affect the Atrial Natriuretic Peptide Gene Expression in vivo in Rats

Hong, Ming; Yan, Qi; Bao, Tengfei; Boersma, Arnold J.; Han, Kia‐Ki; Vantyghem, Marie-Christine; Racadot, A; Lefèbvre, Jean Louis

doi:10.1515/bchm3.1992.373.1.213

Cited by 56 publications

(36 citation statements)

References 16 publications

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“…16,17 Furthermore, it has been shown previously that E 2 increases the expression of ANP. 14,28 In concordance with these results, E 2 led to an increase in ANP expression in the ventricles of animals with pressure overload compared with placebo. These findings suggest that the antihypertrophic effect of E 2 may be mediated by the increased expression of ANP.…”

Section: Discussionsupporting

confidence: 71%

17β-Estradiol Attenuates the Development of Pressure-Overload Hypertrophy

et al. 2001

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Background-Cardiac hypertrophy is an independent risk factor for cardiovascular morbidity and mortality in men and in women. Epidemiological studies indicate that estrogen replacement therapy is cardioprotective; the mechanisms involved in this process, however, are poorly understood. We therefore studied the effect of 17␤-estradiol (E 2 ) on the development of pressure-overload hypertrophy. Methods and Results-Ovariectomized mice receiving E 2 or placebo underwent transverse aortic constriction (TAC) or sham operation. TAC led to a significant increase in ventricular mass compared with sham operation. E 2 treatment reduced cardiac hypertrophy by 31% and 26% compared with placebo 4 and 8 weeks after TAC, whereas it had no effect on the degree of pressure overload, as determined by hemodynamic measurements. Furthermore, E 2 blocked the increased phosphorylation of p38-mitogen-activated protein kinase (MAPK) observed in the placebo-treated animals with TAC. No differences were observed in the phosphorylation of extracellular signal-regulated kinase (ERK) 1/2 and c-Jun N-terminal kinase (JNK) 1/2 between the groups. E 2 had no effect on the expression of angiotensin-converting enzyme (ACE) or the angiotensin II type 1 receptor. Ventricular atrial natriuretic peptide (ANP) expression was detected only in the animals with TAC. Compared with placebo, E 2 treatment led to an increased expression of ANP in animals with pressure overload. Conclusions-Here, we show that E 2 attenuates the hypertrophic response to pressure overload in mice. This observation demonstrates that hormone replacement therapy with E 2 has direct effects on the heart and may be beneficial in the treatment of postmenopausal women to reduce cardiac hypertrophy. Key Words: hormones Ⅲ hypertrophy Ⅲ myocardium Ⅲ sex T he increase of left ventricular mass represents the structural mechanism of adaptation of the heart in response to pressure overload. The resulting left ventricular hypertrophy is an important negative predictor of cardiac morbidity and mortality and displays significant sex-based differences. 1,2 Estrogen is known to have multiple protective effects on the cardiovascular system. 3 The role of estrogen in the development of cardiac hypertrophy, however, is poorly understood. See p 1333We have shown previously that cardiac myocytes and cardiac fibroblasts contain both known estrogen receptor isoforms, called ␣ and ␤. 4 Via these receptors, estrogen can regulate the cardiac expression of endothelial and inducible NO synthase and connexin 43. 5 Estrogen also modulates the activity of the mitogen-activated protein kinase (MAPK) pathways in cardiac myocytes. 6 The MAPK signaling pathways consist of a sequence of successively acting kinases that ultimately result in the dual phosphorylation and activation of effector kinases such as p38-MAPKs, c-Jun N-terminal kinases (JNKs), and extracellular signal-regulated kinases (ERKs), which subsequently phosphorylate a large array of targets, leading to altered gene expression patterns. 7 These signalin...

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Section: Discussionsupporting

confidence: 71%

17β-Estradiol Attenuates the Development of Pressure-Overload Hypertrophy

et al. 2001

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“…One murine-based study demonstrated that treatment with estradiol and progesterone stimulated NP gene expression in females (30 ), while another study demonstrated that testosterone suppressed volumestimulated NP release from isolated perfused rat atria (31 ). Clinically, a study of postmenopausal women demonstrated a significant increase in mean BNP concentrations after transdermal estradiol administration (32 ), while observational studies have identified inverse correlations between circulating androgens and NP concentrations (Fig.…”

Section: Natriuretic Peptidesmentioning

confidence: 99%

Biomarkers in ACS and Heart Failure: Should Men and Women Be Interpreted Differently?

et al. 2014

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BACKGROUND:Sex-based differences exist in the circulating concentrations of certain novel and established biomarkers in patients with acute coronary syndromes (ACS) and heart failure (HF). However, to date, few studies have compared the diagnostic and prognostic utility of these markers in men vs women.CONTENT: This mini-review contains a discussion of the published reports of studies that have explored whether differences in biomarker concentrations exist between men and women with ACS or HF. It also examines those studies that have compared the utility of biomarkers for diagnosis or risk stratification in women vs men. Because biomarkers are often used to make therapeutic and triage decisions in patient care, the potential clinical implications for any observed differences in biomarker reference limits for men and women is discussed.

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“…The activation of these receptors leads to a reduction in preload by the elimination of water and sodium and by shifting plasma volume from intravascular to extravascular spaces 20 . The natriuretic and diuretic actions of NPR-A result from enhanced glomerular filtration and/or decreased tubular reabsorption of sodium and water, suppression of renin, aldosterone, and vasopressin secretion as well as antagonism of most of the peripheral and central effects of angiotensin II 19,21 . If the chronic training promotes a parallel increase of NPRs and NPs, then this also explains the concomitant increased production of NO and NPs 22 , observed by Gutkowska et al 14 .…”

Section: Discussionmentioning

confidence: 99%

Effects of Aerobic Training on the Cardiomyocytes of the Right Atrium of Mice

Oliveira

Maifrino

Pithon‐Curi

et al. 2016

Rev Bras Med Esporte

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Introduction: Polypeptide hormones (natriuretic peptides, NPs) are secreted by the cardiac atria and play an important role in the regulation of blood pressure. Objective: To evaluate the effects of aerobic training on the secretory apparatus of NPs in cardiomyocytes of the right atrium. Methods: Nine-month-old mice were divided in two groups (n=10): control group (CG) and trained group (TG). The training protocol was performed on a motor treadmill for 8 weeks. Systolic blood pressure was measured at the beginning of the experiment (9 months of age) and at moment of the sacrifice (11 months of age). Electron micrographs were used to quantify the following variables: the quantitative density and area of NP granules, the relative volumes of the mitochondria, endoplasmic reticulum, and Golgi complex and the relative volume of euchromatin in the nucleus and the number of pores per 10 µm of the nuclear membrane. The results were compared by Student's t test (p< 0.05). Results: The cardiomyocytes obtained from TG mice showed increased density and sectional area of secretory granules of NP, higher relative volume of endoplasmic reticulum, mitochondria, and Golgi complex compared with the CG mice. Furthermore, the quantitative density of nuclear pores and the relative volume of euchromatin in the nucleus were significantly higher compared with the CG mice. Conclusion: Aerobic training caused hypertrophy of the secretory apparatus in the cardiomyocytes of right atrium, which could explain the intense synthesis of natriuretic peptides in trained mice with respect to the untrained mice.

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Estradiol, Progesterone and Testosterone Exposures Affect the Atrial Natriuretic Peptide Gene Expression in vivo in Rats

Cited by 56 publications

References 16 publications

17β-Estradiol Attenuates the Development of Pressure-Overload Hypertrophy

17β-Estradiol Attenuates the Development of Pressure-Overload Hypertrophy

Biomarkers in ACS and Heart Failure: Should Men and Women Be Interpreted Differently?

Effects of Aerobic Training on the Cardiomyocytes of the Right Atrium of Mice

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