Estradiol influences oxytocin-immunoreactive brain systems

Jirikowski, Gustav F.; Caldwell, Jack D.; Pedersen, Cort A.; Stumpf, Walter E.

doi:10.1016/0306-4522(88)90022-x

Cited by 107 publications

(54 citation statements)

References 21 publications

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“…4 While it is not yet clear where the oxytocin neurons that project to the MPOA and VTA lie, the dorsolateral preoptic area, rostral paraventricular nucleus and anterior commissural nucleus have been implicated. 27 We have previously suggested a possible neurochemical pathway by which cocaine may be interacting with the oxytocinergic system. 8,14 The ascending mesolimbic dopaminergic system (A10), which originates in the VTA, projects to both the HIP and the AMY.…”

Section: Discussionmentioning

confidence: 99%

Chronic gestational cocaine treatment decreases oxytocin levels in the medial preoptic area, ventral tegmental area and hippocampus in Sprague-Dawley rats

et al. 1997

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SummaryWe examined the effects of gestational cocaine treatment on oxytocin levels in the whole hippocampus (HIP), ventral tegmental area (VTA), medial preoptic area (MPOA) and amygdala (AMY) in rat dams on postpartum days (PPDs) 1 and 2. Cocaine treatment significantly reduced oxytocin levels in the MPOA within 12-16 h of delivery (PPD 1), but had no significant effect on the other brain areas. Oxytocin was significantly reduced in the HIP and VTA but not in the AMY or MPOA on PPD 2. These data provide the first evidence for the reduction of oxytocin levels in the VTA, HIP and MPOA as a result of gestational cocaine treatment.

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Section: Discussionmentioning

confidence: 99%

Chronic gestational cocaine treatment decreases oxytocin levels in the medial preoptic area, ventral tegmental area and hippocampus in Sprague-Dawley rats

et al. 1997

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“…As transcription from the rat and human oxytocin promoters could be shown to bc stimulated by estrogens (20,21) this type of regulation was suspected to be a general phenomenon, especially since estrogens have been shown to up-regulate oxytocin production from the hypothalamus in vivo (38). However, comparison with the mouse and bovine sequences, which show a less well conserved estrogen-responsive element ( I 8, 14), together with the transfection studies showing no estrogen stimulation of transcription from the bovine oxytocin promoter (22), as well as the results presented here, all indicate that this view is probably incorrect.…”

Section: Discussionmentioning

confidence: 99%

Mapping of the Bovine Oxytocin Gene Control Region: Identification of Binding Sites for Luteal Nuclear Proteins in the 5′ Non‐Coding Region of the Gene

Walther¹,

Wehrenberg²,

Brackmann³

et al. 1991

J Neuroendocrinology

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In view of the small number of hormone-producing cells, the factors regulating oxytocin gene expression in the classic site of synthesis, in the magnocellular neurons of the hypothalamus, have not yet been characterized. In the early bovine corpus luteurn there is a tissue-specific oxytocin expression involving many more cells. This tissue therefore was chosen as a experimental system to identify deoxyribonucleic acid elements and nuclear proteins involved in the regulation of oxytocin gene expression. 3.2 kb from the 5' non-coding region of the bovine oxytocin gene have been sequenced and subcloned fragments used as probes for gel retardation and footprinting experiments. Binding sites for luteal as well as more ubiquitous proteins were detected in the oxytocin promoter region and in an artiodactyl-specific dispersed repeated deoxyribonucleic acid element. A binding site in the promoter region with a superficial similarity to an estrogen-responsive element (-159 to -152) was shown not to bind this steroid hormone receptor but to bind two nuclear proteins alternatively. One is a luteal protein, the other a more general transcription factor belonging to the steroid hormone receptor superfamily and similar, if not identical to the COUP protein. This alternative binding of a tissue-and phase-specifically expressed protein or an ubiquitous factor to the same site in the oxytocin promoter suggests a role for these two proteins in the transient up-regulation and subsequent down-regulation of the oxytocin gene during the differentiation of the bovine corpus luteum.

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“…[49][50][51][52][53][54][55][56][57] Furthermore, recent studies have provided evidence of a gonadal steroid modulatory role on OT synthesis in the hypothalamus and of gonadal steroid induction of OT receptors in the anterior pituitary (see chapters by Brooks, Johnson, Pfaff et al, and Schumacher et al). 13 An important consideration is whether or not the OT secretory activity in the median eminence alters with the dynamic changes of the plasma level of gonadal steroids during the reproductive cycle.…”

Section: Plasma Oxytocin Release During Reproductive Cyclementioning

confidence: 99%

Pituitary Portal Plasma Levels of Oxytocin during the Estrous Cycle, Lactation, and Hyperprolactinemia

Sarkar

Frautschy

Mitsugi

1992

Annals of the New York Academy of Sciences

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Estradiol influences oxytocin-immunoreactive brain systems

Cited by 107 publications

References 21 publications

Chronic gestational cocaine treatment decreases oxytocin levels in the medial preoptic area, ventral tegmental area and hippocampus in Sprague-Dawley rats

Chronic gestational cocaine treatment decreases oxytocin levels in the medial preoptic area, ventral tegmental area and hippocampus in Sprague-Dawley rats

Mapping of the Bovine Oxytocin Gene Control Region: Identification of Binding Sites for Luteal Nuclear Proteins in the 5′ Non‐Coding Region of the Gene

Pituitary Portal Plasma Levels of Oxytocin during the Estrous Cycle, Lactation, and Hyperprolactinemia

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